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Eukaryotic translation initiation factor 2B tetramer
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8tqo
Q-score: 0.495
Lawrence RE, Shoemaker SR, Deal A, Sangwan S, Anand AA, Wang L, Marqusee S, Walter P
Nat Chem Biol (2024) 20 pp. 422-431 [ Pubmed: 37945896 DOI: doi:10.1038/s41589-023-01453-9 ]
- Translation initiation factor eif-2b subunit epsilon (80 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit gamma (50 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit delta (57 kDa, Protein from Homo sapiens)
- Translation initiation factor 2b decamer (530 kDa, Complex from Homo sapiens)
- Translation initiation factor eif-2b subunit beta (41 kDa, Protein from Homo sapiens)
Eukaryotic translation initiation factor 2B with a mutation (L516A) in the delta subunit
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8tqz
Q-score: 0.519
Lawrence RE, Shoemaker SR, Deal A, Sangwan S, Anand AA, Wang L, Marqusee S, Walter P
Nat Chem Biol (2024) 20 pp. 422-431 [ Pubmed: 37945896 DOI: doi:10.1038/s41589-023-01453-9 ]
- Translation initiation factor eif-2b subunit alpha (35 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit epsilon (80 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit gamma (50 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit delta (57 kDa, Protein from Homo sapiens)
- Translation initiation factor 2b decamer (530 kDa, Complex from Homo sapiens)
- Translation initiation factor eif-2b subunit beta (41 kDa, Protein from Homo sapiens)
Legionella effector protein SidI
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8jhu
Q-score: 0.526
Subramanian A, Wang L, Moss T, Voorhies M, Sangwan S, Stevenson E, Pulido EH, Kwok S, Chalkley RJ, Li KH, Krogan NJ, Swaney DL, Burlingame AL, Floor SN, Sil A, Walter P, Mukherjee S
Nat Cell Biol (2023) 25 pp. 1600-1615 [ DOI: doi:10.1038/s41556-023-01248-z Pubmed: 37857833 ]
- Legionella pneumophila effector protein sidi (134 kDa, Protein from Legionella pneumophila subsp. pneumophila str. Philadelphia 1)
- Legionella pneumophila effector proein sidi (100 kDa, Complex from Legionella pneumophila)
- Legionella pneumophila effector protein sidi (Complex from Legionella pneumophila)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7upr
Q-score: 0.444
Wang L, Toutkoushian H, Belyy V, Kokontis CY, Walter P
eLife (2022) 11 [ DOI: doi:10.7554/eLife.73941 Pubmed: 35550246 ]
- Atad1-substrate complex in closed conformation (200 kDa, Complex from Homo sapiens)
- Outer mitochondrial transmembrane helix translocase (38 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Unknown peptide substrate (869 Da, Protein from Escherichia coli)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7upt
Q-score: 0.404
Wang L, Toutkoushian H, Belyy V, Kokontis CY, Walter P
eLife (2022) 11 [ DOI: doi:10.7554/eLife.73941 Pubmed: 35550246 ]
- Unknown peptide substrate (869 Da, Protein from Escherichia coli)
- Outer mitochondrial transmembrane helix translocase (38 kDa, Protein from Homo sapiens)
- Atad1-substrate complex in open conformation (200 kDa, Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7trj
Q-score: 0.511
Boone M, Wang L, Lawrence R, Frost A, Walter P, Schoof M
eLife (2022) 11 [ Pubmed: 35416150 DOI: doi:10.7554/eLife.76171 ]
- Translation initiation factor eif-2b subunit beta (39 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b decamer (500 kDa, Complex from Homo sapiens)
- Translation initiation factor eif-2b subunit epsilon (80 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit gamma (50 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit alpha (33 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit delta (57 kDa, Protein from Homo sapiens)
CryoEM structure of Mycobacterium tuberculosis UMP Kinase (UMPK) in complex with UDP and UTP
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 7bes
Q-score: 0.551
Walter P, Mechaly A, Bous J, Haouz A, England P, Lai-Kee-Him J, Ancelin A, Hoos S, Baron B, Trapani S, Bron P, Labesse G, Munier-Lehmann H
FEBS J (2022) 289 pp. 4869-4887 [ DOI: doi:10.1111/febs.16393 Pubmed: 35152545 ]
- Uridine 5'-triphosphate (484 Da, Ligand)
- Uridylate kinase (29 kDa, Protein from Mycobacterium tuberculosis)
- Umpk-udp-utp (177 kDa, Complex from Mycobacterium tuberculosis)
- Uridine-5'-diphosphate (404 Da, Ligand)
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7rlo
Q-score: 0.546
Schoof M, Wang L, Cogan JZ, Lawrence RE, Boone M, Wuerth JD, Frost A, Walter P
Nat Commun (2021) 12 pp. 7103-7103 [ DOI: doi:10.1038/s41467-021-26164-4 Pubmed: 34876554 ]
- Eukaryotic translation initiation factor 2b in complex with sfsv nss (500 kDa, Complex)
- Non-structural protein ns-s (30 kDa, Protein from Sandfly fever sicilian virus)
- Translation initiation factor eif-2b subunit epsilon (80 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit gamma (50 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit alpha (33 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit delta (57 kDa, Protein from Homo sapiens)
- Nss protein of sandfly fever sicilian phlebovirus (Complex from Sandfly fever Sicilian virus)
- Translation initiation factor eif-2b subunit (Complex from Homo sapiens)
- Translation initiation factor eif-2b subunit beta (39 kDa, Protein from Homo sapiens)
The stress-sensing domain of activated IRE1a forms helical filaments in narrow ER membrane tubes
Tran NH, Carter SD, De Maziere A, Ashkenazi A, Klumperman J, Walter P, Jensen GJ
Science (2021) 374 pp. 52-57 [ DOI: doi:10.1126/science.abh2474 Pubmed: 34591618 ]
The stress-sensing domain of activated IRE1a forms helical filaments in narrow ER membrane tubes
Tran NH, Carter SD, De Maziere A, Ashkenazi A, Klumperman J, Walter P, Jensen GJ
Science (2021) 374 pp. 52-57 [ DOI: doi:10.1126/science.abh2474 Pubmed: 34591618 ]