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grant_code:"MDA 352845"

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Current Database

  • EMDB [18]

Current status

  • REL [18]

Sample type

  • Complex [18]
  • Protein [18]
  • Ligand [13]

Organism

  • Oryctolagus cuniculus [16]
  • Homo sapiens [7]
  • Mus musculus [2]

EM Method

  • Single-particle [18]

Resolution

  • ≥ 3Å and < 4Å [12]
  • ≥ 4Å and < 5Å [5]
  • ≥ 5Å and < 6Å [1]

Model molecular weight

  • 2-5 MDa [13]

Release Date

  • 2024 [4]
  • 2023 [1]
  • 2022 [6]
  • 2021 [4]
  • 2020 [3]

Author by name

  • Samso M [18]
  • Nayak AR [14]
  • Iyer KA [7]
  • Murayama T [7]
  • Hu Y [5]
  • Kobayashi T [4]
  • Kurebayashi N [3]
  • Lobo JJ [3]
  • Rangubpit W [3]
  • Sompornpisut P [3]
  • Will AH [3]
  • Castro-hartmann P [2]
  • Dryden K [2]
  • Lamb GD [2]
  • Hartmann PC [1]

Author by ORCID

  • Samso M [15]
  • Nayak AR [11]
  • Murayama T [6]
  • Iyer KA [4]

Journal

  • ELIFE [8]
  • SCI ADV [3]
  • STRUCTURE [3]
  • NAT COMMUN [2]
  • TO BE PUBLISHED [2]

Software

  • RELION [11]
  • CRYOSPARC [6]
  • GCTF [2]
  • FREALIGN [1]
  • SPIDER [1]

Microscope

  • FEI TITAN KRIOS [16]
  • TFS KRIOS [2]

Electron Source

  • FIELD EMISSION GUN [18]

Film or detector model

  • GATAN K3 6K X 4K [12]
  • GATAN K2 SUMMIT 4K X 4K [6]

External links

  • Complex Portal [18]
  • PDBe-Kb [18]
  • UniProt [18]
  • ChEBI [13]
  • ChEMBL [13]
  • DrugBank [13]
  • PDB [13]
  • Gene Ontology [10]
  • InterPro [10]
  • Pfam [10]
  • AlphaFold DB [7]
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EMD-45493
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3D View
Rabbit RyR1 disease mutant Y523S in complex with FKBP12.6, nanodisc and inhibitor dantrolene in the absence of calcium
Release date: Dec. 11, 2024
Resolution: 3.34 Å
EM Method: Single-particle

Iyer KA, Kobayashi T, Murayama T, Samso M

Structure (2025) 33 pp. 338-348.e4 [ Pubmed: 39708816 DOI: doi:10.1016/j.str.2024.11.018 ]

EMD-45497
Download Map
3D View
Rabbit RyR1 disease mutant Y523S in complex with FKBP12.6, nanodisc and inhibitor dantrolene in the presence of activating calcium
Release date: Dec. 11, 2024
Resolution: 3.23 Å
EM Method: Single-particle

Iyer KA, Kobayashi T, Murayama T, Samso M

Structure (2025) 33 pp. 338-348.e4 [ Pubmed: 39708816 DOI: doi:10.1016/j.str.2024.11.018 ]

EMD-45584
Composite map
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3D View
RyR1 disease mutant Y523S with FKBP12.6, nanodisc and inhibitor dantrolene in the absence of calcium with refined P1 domain
Release date: Dec. 11, 2024
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 9cgp
Q-score: 0.408

Iyer KA, Kobayashi T, Murayama T, Samso M

Structure (2025) 33 pp. 338-348.e4 [ Pubmed: 39708816 DOI: doi:10.1016/j.str.2024.11.018 ]

EMD-45585
Composite map
Download Map
3D View
Rabbit RyR1 disease mutant Y523S in complex with FKBP12.6, nanodisc and inhibitor dantrolene in the presence of activating calcium
Release date: Dec. 11, 2024
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 9cgq
Q-score: 0.463

Iyer KA, Kobayashi T, Murayama T, Samso M

To Be Published

EMD-26610
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3D View
Cryo-EM structure of rabbit RyR1 in the presence of high Mg2 and AMP-PCP in nanodisc
Release date: April 12, 2023
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 7umz
Q-score: 0.381

Nayak AR, Rangubpit W, Will AH, Hu Y, Castro-Hartmann P, Lobo JJ, Dryden K, Lamb GD, Sompornpisut P, Samso M

Nat Commun (2024) 15 pp. 4115- [ DOI: doi:10.1038/s41467-024-48292-3 ]

EMD-25828
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3D View
Rabbit RyR1 with AMP-PCP and high Ca2 embedded in nanodisc in inactivated conformation Dataset-A
Release date: March 9, 2022
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7tdg
Q-score: 0.386

Nayak AR, Samso M

eLife (2022) 11 [ DOI: doi:10.7554/eLife.75568 Pubmed: 35257661 ]

EMD-25829
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3D View
Rabbit RyR1 with AMP-PCP and high Ca2 embedded in nanodisc in open conformation
Release date: March 9, 2022
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7tdh
Q-score: 0.215

Nayak AR, Samso M

eLife (2022) 11 [ DOI: doi:10.7554/eLife.75568 Pubmed: 35257661 ]

EMD-25830
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3D View
Rabbit RyR1 with AMP-PCP and high Ca2 embedded in nanodisc in closed-inactivated conformation class 2 Dataset-A
Release date: March 9, 2022
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7tdi
Q-score: 0.332

Nayak AR, Samso M

eLife (2022) 11 [ DOI: doi:10.7554/eLife.75568 Pubmed: 35257661 ]

EMD-25831
Download Map
3D View
Rabbit RyR1 with AMP-PCP and high Ca2 embedded in nanodisc in closed-inactivated conformation class 1 Dataset-A
Release date: March 9, 2022
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7tdj
Q-score: 0.365

Nayak AR, Samso M

eLife (2022) 11 [ DOI: doi:10.7554/eLife.75568 Pubmed: 35257661 ]

EMD-25832
Download Map
3D View
Rabbit RyR1 with AMP-PCP and high Ca2 embedded in nanodisc in closed-inactivated conformation class 3 Dataset-A
Release date: March 9, 2022
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7tdk
Q-score: 0.357

Nayak AR, Samso M

eLife (2022) 11 [ DOI: doi:10.7554/eLife.75568 Pubmed: 35257661 ]

Sort by: Download
Showing 1 - 10 of 18. Page 1 of 2
Display:
Statistics
×

Download











































Preview first 10
Download

Filter By

Current Database

  • EMDB [18]

Current status

  • REL [18]

Sample type

  • Complex [18]
  • Protein [18]
  • Ligand [13]

Organism

  • Oryctolagus cuniculus [16]
  • Homo sapiens [7]
  • Mus musculus [2]

EM Method

  • Single-particle [18]

Resolution

  • ≥ 3Å and < 4Å [12]
  • ≥ 4Å and < 5Å [5]
  • ≥ 5Å and < 6Å [1]

Model molecular weight

  • 2-5 MDa [13]

Release Date

  • 2024 [4]
  • 2023 [1]
  • 2022 [6]
  • 2021 [4]
  • 2020 [3]

Author by name

  • Samso M [18]
  • Nayak AR [14]
  • Iyer KA [7]
  • Murayama T [7]
  • Hu Y [5]
  • Kobayashi T [4]
  • Kurebayashi N [3]
  • Lobo JJ [3]
  • Rangubpit W [3]
  • Sompornpisut P [3]
  • Will AH [3]
  • Castro-hartmann P [2]
  • Dryden K [2]
  • Lamb GD [2]
  • Hartmann PC [1]

Author by ORCID

  • Samso M [15]
  • Nayak AR [11]
  • Murayama T [6]
  • Iyer KA [4]

Journal

  • ELIFE [8]
  • SCI ADV [3]
  • STRUCTURE [3]
  • NAT COMMUN [2]
  • TO BE PUBLISHED [2]

Software

  • RELION [11]
  • CRYOSPARC [6]
  • GCTF [2]
  • FREALIGN [1]
  • SPIDER [1]

Microscope

  • FEI TITAN KRIOS [16]
  • TFS KRIOS [2]

Electron Source

  • FIELD EMISSION GUN [18]

Film or detector model

  • GATAN K3 6K X 4K [12]
  • GATAN K2 SUMMIT 4K X 4K [6]

External links

  • Complex Portal [18]
  • PDBe-Kb [18]
  • UniProt [18]
  • ChEBI [13]
  • ChEMBL [13]
  • DrugBank [13]
  • PDB [13]
  • Gene Ontology [10]
  • InterPro [10]
  • Pfam [10]
  • AlphaFold DB [7]