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EMD-45584

Composite map
Single-particle
3.34 Å
EMD-45584
3D View Gallery
Deposition: 30/06/2024
Map released: 11/12/2024
Last modified: 19/02/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-45584
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9cgp summary report (pdf.gz) Map and 9cgp FULL report (pdf.gz)
EMICSS annotations (xml)

RyR1 disease mutant Y523S with FKBP12.6, nanodisc and inhibitor dantrolene in the absence of calcium with refined P1 domain

EMD-45584

Composite map
Single-particle
3.34 Å
EMD-45584
3D View Gallery
Deposition: 30/06/2024
Map released: 11/12/2024
Last modified: 19/02/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Oryctolagus cuniculus, Homo sapiens
Sample: RyR1 disease mutant Y523S with FKBP12.6, nanodisc and inhibitor dantrolene in the absence of calcium with refined P1 domain
Fitted models: 9cgp

Deposition Authors: Iyer KA , Samso M
Dantrolene inhibition of ryanodine receptor 1 carrying the severe malignant hyperthermia mutation Y522S visualized by cryo-EM.
Iyer KA , Kobayashi T, Murayama T , Samso M
(2025) Structure , 33 , 338 - 348.e4
PUBMED: 39708816
DOI: doi:10.1016/j.str.2024.11.018
ISSN: 0969-2126
ASTM: STRUE6