EMD-45584

Single-particle
3.34 Å
EMD-45584
3D View Gallery
Deposition: 30/06/2024
Map released: 11/12/2024
Last modified: 19/02/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-45584

Archive Files (Depositor)

Primary 3D volume (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9cgp summary report (pdf.gz) Map-9cgp FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

RyR1 disease mutant Y523S with FKBP12.6, nanodisc and inhibitor dantrolene in the absence of calcium with refined P1 domain

EMD-45584

Single-particle
3.34 Å
EMD-45584
3D View Gallery
Deposition: 30/06/2024
Map released: 11/12/2024
Last modified: 19/02/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Oryctolagus cuniculus, Homo sapiens
Sample: RyR1 disease mutant Y523S with FKBP12.6, nanodisc and inhibitor dantrolene in the absence of calcium with refined P1 domain
Fitted models: 9cgp

Deposition Authors: Iyer KA , Samso M
Dantrolene inhibition of ryanodine receptor 1 carrying the severe malignant hyperthermia mutation Y522S visualized by cryo-EM.
Iyer KA , Kobayashi T, Murayama T , Samso M
(2025) Structure , 33 , 338 - 348.e4
PUBMED: 39708816
DOI: doi:10.1016/j.str.2024.11.018
ISSN: 0969-2126
ASTM: STRUE6