EMD-45497

Single-particle
3.23 Å
EMD-45497
3D View Gallery
Deposition: 26/06/2024
Map released: 11/12/2024
Last modified: 16/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-45497

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Rabbit RyR1 disease mutant Y523S in complex with FKBP12.6, nanodisc and inhibitor dantrolene in the presence of activating calcium

EMD-45497

Single-particle
3.23 Å
EMD-45497
3D View Gallery
Deposition: 26/06/2024
Map released: 11/12/2024
Last modified: 16/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Oryctolagus cuniculus, Homo sapiens
Sample: Rabbit RyR1 disease mutant Y523S in complex with FKBP12.6, nanodisc and inhibitor dantrolene in the presence of activating calcium

Deposition Authors: Iyer KA , Samso M
Dantrolene inhibition of ryanodine receptor 1 carrying the severe malignant hyperthermia mutation Y522S visualized by cryo-EM.
Iyer KA , Kobayashi T, Murayama T , Samso M
(2025) Structure , 33 , 338 - 348.e4
PUBMED: 39708816
DOI: doi:10.1016/j.str.2024.11.018
ISSN: 0969-2126
ASTM: STRUE6