EMD-45585

Single-particle
3.23 Å
EMD-45585
3D View Gallery
Deposition: 30/06/2024
Map released: 11/12/2024
Last modified: 16/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-45585

Archive Files (Depositor)

Primary 3D volume (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9cgq summary report (pdf.gz) Map-9cgq FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

Rabbit RyR1 disease mutant Y523S in complex with FKBP12.6, nanodisc and inhibitor dantrolene in the presence of activating calcium

EMD-45585

Single-particle
3.23 Å
EMD-45585
3D View Gallery
Deposition: 30/06/2024
Map released: 11/12/2024
Last modified: 16/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Oryctolagus cuniculus, Homo sapiens
Sample: RyR1 disease mutant Y523S with FKBP12.6, nanodisc and inhibitor dantrolene in the presence of activating calcium with refined P1 domain
Fitted models: 9cgq

Deposition Authors: Iyer KA, Samso M
Dantrolene inhibition of ryanodine receptor 1 carrying the severe malignant hyperthermia mutation Y522S visualized by cryo-EM.
Iyer KA, Kobayashi T, Murayama T , Samso M
(2025) Structure , 33 , 338 - 348.e4
PUBMED: 39708816
DOI: doi:10.1016/j.str.2024.11.018
ISSN: 0969-2126
ASTM: STRUE6