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EMD-45493

Single-particle
3.34 Å
EMD-45493
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Deposition: 26/06/2024
Map released: 11/12/2024
Last modified: 16/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-45493
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Rabbit RyR1 disease mutant Y523S in complex with FKBP12.6, nanodisc and inhibitor dantrolene in the absence of calcium

EMD-45493

Single-particle
3.34 Å
EMD-45493
3D View Gallery
Deposition: 26/06/2024
Map released: 11/12/2024
Last modified: 16/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Oryctolagus cuniculus, Homo sapiens
Sample: Rabbit RyR1 disease mutant Y523S in complex with FKBP12.6, nanodisc and inhibitor dantrolene in the absence of calcium

Deposition Authors: Iyer KA , Samso M
Dantrolene inhibition of ryanodine receptor 1 carrying the severe malignant hyperthermia mutation Y522S visualized by cryo-EM.
Iyer KA , Kobayashi T, Murayama T , Samso M
(2025) Structure , 33 , 338 - 348.e4
PUBMED: 39708816
DOI: doi:10.1016/j.str.2024.11.018
ISSN: 0969-2126
ASTM: STRUE6