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grant_code:"AI161880"

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Current Database

  • EMDB [17]

Current status

  • REL [17]

Sample type

  • Complex [17]
  • Protein [13]
  • Ligand [7]

Organism

  • Homo sapiens [14]
  • Bos taurus [9]
  • Synthetic construct [6]
  • Lama glama [2]

EM Method

  • Single-particle [17]

Resolution

  • ≥ 3Å and < 4Å [12]
  • ≥ 4Å and < 5Å [4]
  • ≥ 6Å and < 8Å [1]

Model molecular weight

  • 50-100 kDa [1]
  • 100-250 kDa [12]

Release Date

  • 2025 [10]
  • 2022 [7]

Author by name

  • Gustavsson M [17]
  • Handel TM [17]
  • Kossiakoff AA [17]
  • Schafer CT [17]
  • Tesmer JJG [17]
  • Agrawal P [10]
  • Aydin Y [10]
  • Chen Q [10]
  • Fuller JR [10]
  • Kihara D [10]
  • Lamme TD [10]
  • Mukherjee S [10]
  • Tepper K [10]
  • Terashi G [10]
  • Wang K [10]
  • Yao XQ [10]
  • Deneka D [7]
  • Dominik PK [7]
  • Eberle SA [7]
  • Schall TJ [7]
  • Yen YC [7]
  • Zhang P [7]
  • Fuller J [1]

Author by ORCID

  • Schafer CT [17]
  • Handel TM [17]
  • Gustavsson M [17]
  • Tesmer JJG [17]
  • Mukherjee S [10]
  • Wang K [10]
  • Terashi G [10]
  • Chen Q [10]
  • Fuller JR [10]
  • Aydin Y [10]
  • Kossiakoff AA [10]
  • Kihara D [10]
  • Lamme TD [10]
  • Zhang P [7]
  • Deneka D [7]
  • Eberle SA [7]
  • Yen YC [7]

Journal

  • NATURE [10]
  • SCI ADV [7]

Software

  • CRYOSPARC [16]

Microscope

  • FEI TITAN KRIOS [15]
  • TFS KRIOS [2]

Electron Source

  • FIELD EMISSION GUN [17]

Film or detector model

  • GATAN K3 6K X 4K [17]

External links

  • AlphaFold DB [13]
  • Gene Ontology [13]
  • InterPro [13]
  • PDB [13]
  • PDBe-Kb [13]
  • Pfam [13]
  • UniProt [13]
  • ChEBI [7]
  • ChEMBL [7]
  • DrugBank [7]
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Showing 1 - 10 of 17. Page 1 of 2
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EMD-47700
Download Map
3D View
ACKR3 phosphorylated by GRK5 in complex with arrestin2 and Fab7
Release date: April 2, 2025
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 9e82
Q-score: 0.289

Chen Q, Schafer CT, Mukherjee S, Wang K, Gustavsson M, Fuller JR, Tepper K, Lamme TD, Aydin Y, Agrawal P, Terashi G, Yao XQ, Kihara D, Kossiakoff AA, Handel TM, Tesmer JJG

Nature (2025) 643 pp. 280-287 [ Pubmed: 40399676 DOI: doi:10.1038/s41586-025-09024-9 ]

EMD-49564
Download Map
3D View
cryoEM structure of human ACKR3 phosphorylated by GRK2 in complex with Arr2
Release date: April 2, 2025
Resolution: 4.1 Å
EM Method: Single-particle

Chen Q, Schafer CT, Mukherjee S, Wang K, Gustavsson M, Fuller JR, Tepper K, Lamme TD, Aydin Y, Agrawal P, Terashi G, Yao XQ, Kihara D, Kossiakoff AA, Handel TM, Tesmer JJG

Nature (2025) 643 pp. 280-287 [ Pubmed: 40399676 DOI: doi:10.1038/s41586-025-09024-9 ]

EMD-41290
Download Map
3D View
Human ACKR3 phosphorylated by GRK5 in complex with Arrestin3
Release date: Jan. 29, 2025
Resolution: 3.9 Å
EM Method: Single-particle

Chen Q, Schafer CT, Mukherjee S, Wang K, Gustavsson M, Fuller JR, Tepper K, Lamme TD, Aydin Y, Agrawal P, Terashi G, Yao XQ, Kihara D, Kossiakoff AA, Handel TM, Tesmer JJG

Nature (2025) 643 pp. 280-287 [ Pubmed: 40399676 DOI: doi:10.1038/s41586-025-09024-9 ]

EMD-41291
Download Map
3D View
Human ACKR3 phosphorylated by GRK2 in complex with Arrestin3
Release date: Jan. 29, 2025
Resolution: 6.9 Å
EM Method: Single-particle

Chen Q, Schafer CT, Mukherjee S, Wang K, Gustavsson M, Fuller JR, Tepper K, Lamme TD, Aydin Y, Agrawal P, Terashi G, Yao XQ, Kihara D, Kossiakoff AA, Handel TM, Tesmer JJG

Nature (2025) 643 pp. 280-287 [ Pubmed: 40399676 DOI: doi:10.1038/s41586-025-09024-9 ]

EMD-41292
Download Map
3D View
Human ACKR3 with C tail extended by 12 glycines phosphorylated by GRK5 in complex with Arrestin2
Release date: Jan. 29, 2025
Resolution: 3.8 Å
EM Method: Single-particle

Chen Q, Schafer CT, Mukherjee S, Wang K, Gustavsson M, Fuller JR, Tepper K, Lamme TD, Aydin Y, Agrawal P, Terashi G, Yao XQ, Kihara D, Kossiakoff AA, Handel TM, Tesmer JJG

Nature (2025) 643 pp. 280-287 [ Pubmed: 40399676 DOI: doi:10.1038/s41586-025-09024-9 ]

EMD-41289
Download Map
3D View
Human ACKR3 phosphorylated by GRK2 in complex with Arrestin2 in nanodisc
Release date: Jan. 22, 2025
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8tii
Q-score: 0.481

Chen Q, Schafer CT, Mukherjee S, Wang K, Gustavsson M, Fuller JR, Tepper K, Lamme TD, Aydin Y, Agrawal P, Terashi G, Yao XQ, Kihara D, Kossiakoff AA, Handel TM, Tesmer JJG

Nature (2025) 643 pp. 280-287 [ Pubmed: 40399676 DOI: doi:10.1038/s41586-025-09024-9 ]

EMD-41295
Download Map
3D View
Human ACKR3 phosphorylated by GRK5 in complex with Arrestin3 reconstructed without receptor/micelle
Release date: Jan. 22, 2025
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8til
Q-score: 0.393

Chen Q, Schafer CT, Mukherjee S, Wang K, Gustavsson M, Fuller JR, Tepper K, Lamme TD, Aydin Y, Agrawal P, Terashi G, Yao XQ, Kihara D, Kossiakoff AA, Handel TM, Tesmer JJG

Nature (2025) 643 pp. 280-287 [ Pubmed: 40399676 DOI: doi:10.1038/s41586-025-09024-9 ]

EMD-41296
Download Map
3D View
Human ACKR3 phosphorylated by GRK2 in complex with Arrestin3 reconstructed without receptor/micelle
Release date: Jan. 22, 2025
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8tin
Q-score: 0.326

Chen Q, Schafer CT, Mukherjee S, Wang K, Gustavsson M, Fuller JR, Tepper K, Lamme TD, Aydin Y, Agrawal P, Terashi G, Yao XQ, Kihara D, Kossiakoff AA, Handel TM, Tesmer JJG

Nature (2025) 643 pp. 280-287 [ Pubmed: 40399676 DOI: doi:10.1038/s41586-025-09024-9 ]

EMD-41297
Download Map
3D View
Human ACKR3 with C tail extended by 12 glycines phosphorylated by GRK5 in complex with Arrestin2 reconstructed without receptor/micelle
Release date: Jan. 22, 2025
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8tio
Q-score: 0.398

Chen Q, Schafer CT, Mukherjee S, Wang K, Gustavsson M, Fuller JR, Tepper K, Lamme TD, Aydin Y, Agrawal P, Terashi G, Yao XQ, Kihara D, Kossiakoff AA, Handel TM, Tesmer JJG

Nature (2025) 643 pp. 280-287 [ Pubmed: 40399676 DOI: doi:10.1038/s41586-025-09024-9 ]

EMD-43277
Download Map
3D View
cryoEM structure of human ACKR3 phosphorylated by GRK5 in complex with Arrestin3 variant with the C edge loop from Arrestin2 inserted
Release date: Jan. 22, 2025
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8vj9
Q-score: 0.378

Chen Q, Schafer CT, Mukherjee S, Wang K, Gustavsson M, Fuller JR, Tepper K, Lamme TD, Aydin Y, Agrawal P, Terashi G, Yao XQ, Kihara D, Kossiakoff AA, Handel TM, Tesmer JJG

Nature (2025) 643 pp. 280-287 [ Pubmed: 40399676 DOI: doi:10.1038/s41586-025-09024-9 ]

Sort by: Download
Showing 1 - 10 of 17. Page 1 of 2
Display:
Statistics
×

Download











































Preview first 10
Download

Filter By

Current Database

  • EMDB [17]

Current status

  • REL [17]

Sample type

  • Complex [17]
  • Protein [13]
  • Ligand [7]

Organism

  • Homo sapiens [14]
  • Bos taurus [9]
  • Synthetic construct [6]
  • Lama glama [2]

EM Method

  • Single-particle [17]

Resolution

  • ≥ 3Å and < 4Å [12]
  • ≥ 4Å and < 5Å [4]
  • ≥ 6Å and < 8Å [1]

Model molecular weight

  • 50-100 kDa [1]
  • 100-250 kDa [12]

Release Date

  • 2025 [10]
  • 2022 [7]

Author by name

  • Gustavsson M [17]
  • Handel TM [17]
  • Kossiakoff AA [17]
  • Schafer CT [17]
  • Tesmer JJG [17]
  • Agrawal P [10]
  • Aydin Y [10]
  • Chen Q [10]
  • Fuller JR [10]
  • Kihara D [10]
  • Lamme TD [10]
  • Mukherjee S [10]
  • Tepper K [10]
  • Terashi G [10]
  • Wang K [10]
  • Yao XQ [10]
  • Deneka D [7]
  • Dominik PK [7]
  • Eberle SA [7]
  • Schall TJ [7]
  • Yen YC [7]
  • Zhang P [7]
  • Fuller J [1]

Author by ORCID

  • Schafer CT [17]
  • Handel TM [17]
  • Gustavsson M [17]
  • Tesmer JJG [17]
  • Mukherjee S [10]
  • Wang K [10]
  • Terashi G [10]
  • Chen Q [10]
  • Fuller JR [10]
  • Aydin Y [10]
  • Kossiakoff AA [10]
  • Kihara D [10]
  • Lamme TD [10]
  • Zhang P [7]
  • Deneka D [7]
  • Eberle SA [7]
  • Yen YC [7]

Journal

  • NATURE [10]
  • SCI ADV [7]

Software

  • CRYOSPARC [16]

Microscope

  • FEI TITAN KRIOS [15]
  • TFS KRIOS [2]

Electron Source

  • FIELD EMISSION GUN [17]

Film or detector model

  • GATAN K3 6K X 4K [17]

External links

  • AlphaFold DB [13]
  • Gene Ontology [13]
  • InterPro [13]
  • PDB [13]
  • PDBe-Kb [13]
  • Pfam [13]
  • UniProt [13]
  • ChEBI [7]
  • ChEMBL [7]
  • DrugBank [7]