CHEBI:50683 - EC 1.5.1.3 (dihydrofolate reductase) inhibitor

ChEBI IDCHEBI:50683
ChEBI NameEC 1.5.1.3 (dihydrofolate reductase) inhibitor
Stars
DefinitionAn EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of dihydrofolate reductase (EC 1.5.1.3).
Last Modified21 June 2018
SubmitterMarcus Ennis
Wikipedia
ChEBI Ontology
Outgoing Relation(s)
EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683) is a antifolate (CHEBI:73913)
EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683) is a EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD+ or NADP+ as acceptor) inhibitor (CHEBI:76863)
Incoming Relation(s)
(R)-iclaprim (CHEBI:131752) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683)
(S)-iclaprim (CHEBI:131753) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683)
O-(chloroacetylcarbamoyl)fumagillol (CHEBI:90748) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683)
4-aminofolic acid (CHEBI:22526) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683)
brodimoprim (CHEBI:131726) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683)
cycloguanil (CHEBI:135029) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683)
iclaprim (CHEBI:131724) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683)
methotrexate (CHEBI:44185) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683)
methotrexate disodium (CHEBI:50679) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683)
pemetrexed (CHEBI:63616) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683)
pemetrexed disodium (CHEBI:63722) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683)
pemetrexed disodium heptahydrate (CHEBI:63723) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683)
pralatrexate (CHEBI:71223) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683)
proguanil (CHEBI:8455) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683)
pyrimethamine (CHEBI:8673) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683)
triclosan (CHEBI:164200) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683)
trimethoprim (CHEBI:45924) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683)
Synonyms  Source
dihydrofolic acid reductase inhibitorsChEBI
EC 1.5.1.3 inhibitorsChEBI
folic acid reductase inhibitorsChEBI
DHFR inhibitorsChEBI
NADPH-dihydrofolate reductase inhibitorChEBI
tetrahydrofolate dehydrogenase inhibitorChEBI
Manual XrefsDatabases
Dihydrofolate_reductase_inhibitorWikipedia