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CHEBI:50683 - EC 1.5.1.3 (dihydrofolate reductase) inhibitor
| ChEBI ID | CHEBI:50683 |
| ChEBI Name | EC 1.5.1.3 (dihydrofolate reductase) inhibitor |
| Stars | |
| Definition | An EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of dihydrofolate reductase (EC 1.5.1.3). |
| Last Modified | 21 June 2018 |
| Submitter | Marcus Ennis |
| Wikipedia |
|---|
| ChEBI Ontology |
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| Outgoing Relation(s) |
| EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683) is a antifolate (CHEBI:73913) |
| EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683) is a EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD+ or NADP+ as acceptor) inhibitor (CHEBI:76863) |
| Incoming Relation(s) |
| (R)-iclaprim (CHEBI:131752) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683) |
| (S)-iclaprim (CHEBI:131753) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683) |
| O-(chloroacetylcarbamoyl)fumagillol (CHEBI:90748) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683) |
| 4-aminofolic acid (CHEBI:22526) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683) |
| brodimoprim (CHEBI:131726) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683) |
| cycloguanil (CHEBI:135029) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683) |
| iclaprim (CHEBI:131724) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683) |
| methotrexate (CHEBI:44185) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683) |
| methotrexate disodium (CHEBI:50679) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683) |
| pemetrexed (CHEBI:63616) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683) |
| pemetrexed disodium (CHEBI:63722) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683) |
| pemetrexed disodium heptahydrate (CHEBI:63723) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683) |
| pralatrexate (CHEBI:71223) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683) |
| proguanil (CHEBI:8455) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683) |
| pyrimethamine (CHEBI:8673) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683) |
| triclosan (CHEBI:164200) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683) |
| trimethoprim (CHEBI:45924) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683) |
| Synonyms | Source |
|---|---|
| 7,8-dihydrofolate reductase inhibitor | ChEBI |
| 7,8-dihydrofolate reductase inhibitors | ChEBI |
| DHFR inhibitor | ChEBI |
| DHFR inhibitors | ChEBI |
| dihydrofolate reductase (EC 1.5.1.3) inhibitor | ChEBI |
| dihydrofolate reductase (EC 1.5.1.3) inhibitors | ChEBI |
| Manual Xrefs | Databases |
|---|---|
| Dihydrofolate_reductase_inhibitor | Wikipedia |