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CHEBI:131724 - iclaprim

ChEBI IDCHEBI:131724
ChEBI Nameiclaprim
Stars
DefinitionA racemate consisting of equimolar amounts of (R)- and (S)-iclaprim. Both enantiomers exhibit similar, potent bactericidal activity against major Gram-positive pathogens, notably methicillin-sensitive and -resistant Staphylococcus aureus (MSSA and MRSA, respectively).
Last Modified22 February 2017
SubmitterKevin
FormulaC19H22N4O3
Net Charge0
Average Mass354.404
Monoisotopic Mass354.16919
Wikipedia
Roles Classification
Biological Roles:
antibacterial drug  A drug used to treat or prevent bacterial infections.
EC 1.5.1.3 (dihydrofolate reductase) inhibitor  An EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of dihydrofolate reductase (EC 1.5.1.3).
Application:
antibacterial drug  A drug used to treat or prevent bacterial infections.
ChEBI Ontology
Outgoing Relation(s)
iclaprim (CHEBI:131724) has part (R)-iclaprim (CHEBI:131752)
iclaprim (CHEBI:131724) has part (S)-iclaprim (CHEBI:131753)
iclaprim (CHEBI:131724) has role antibacterial drug (CHEBI:36047)
iclaprim (CHEBI:131724) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683)
iclaprim (CHEBI:131724) is a racemate (CHEBI:60911)
IUPAC Name 
rac-5-[(2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)methyl]pyrimidine-2,4-diamine
Synonyms  Source
AR 100ChemIDplus
AR-100ChemIDplus
5-((2RS)-2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-ylmethyl)pyrimidine-2,4-diamineChemIDplus
Manual XrefsDatabases
D08337KEGG DRUG
IclaprimWikipedia
Registry NumbersSources
Reaxys:9951587Reaxys
CAS:192314-93-5KEGG DRUG
CAS:192314-93-5ChemIDplus
Citations