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CHEBI:45924 - trimethoprim
| Formula | C14H18N4O3 |
| Net Charge | 0 |
| Average Mass | 290.323 |
| Monoisotopic Mass | 290.13789 |
| SMILES | COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC |
| InChI | InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18) |
| InChIKey | IEDVJHCEMCRBQM-UHFFFAOYSA-N |
| Wikipedia |
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| Roles Classification |
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| Chemical Roles: | environmental contaminant Any minor or unwanted substance introduced into the environment that can have undesired effects. Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid). |
| Biological Roles: | antifungal agent An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce. EC 1.5.1.3 (dihydrofolate reductase) inhibitor An EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of dihydrofolate reductase (EC 1.5.1.3). antimicrobial agent A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. anti-HIV agent An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus. antibacterial agent A substance (or active part thereof) that kills or slows the growth of bacteria. antibacterial drug A drug used to treat or prevent bacterial infections. xenobiotic A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means. drug allergen Any drug which causes the onset of an allergic reaction. antimalarial A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human. antitubercular agent A substance that kills or slows the growth of Mycobacterium tuberculosis and is used in the treatment of tuberculosis. |
| Applications: | antiinfective agent A substance used in the prophylaxis or therapy of infectious diseases. renoprotective agent Any compound that is able to prevent damage to the kidneys. anti-anaemic agent A compound which increases either the number of red cells or the amount of haemoglobin in the blood. antibacterial drug A drug used to treat or prevent bacterial infections. hypoglycemic agent A drug which lowers the blood glucose level. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. dermatologic drug A drug used to treat or prevent skin disorders or for the routine care of skin. diuretic An agent that promotes the excretion of urine through its effects on kidney function. drug allergen Any drug which causes the onset of an allergic reaction. antimalarial A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human. antitubercular agent A substance that kills or slows the growth of Mycobacterium tuberculosis and is used in the treatment of tuberculosis. antifibrotic agent Any agent which acts to reduce fibrosis. ophthalmology drug Any compound used for the treatment of eye conditions or eye diseases. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| trimethoprim (CHEBI:45924) has role anti-anaemic agent (CHEBI:75835) |
| trimethoprim (CHEBI:45924) has role anti-HIV agent (CHEBI:64946) |
| trimethoprim (CHEBI:45924) has role antibacterial agent (CHEBI:33282) |
| trimethoprim (CHEBI:45924) has role antibacterial drug (CHEBI:36047) |
| trimethoprim (CHEBI:45924) has role antifibrotic agent (CHEBI:233423) |
| trimethoprim (CHEBI:45924) has role antifungal agent (CHEBI:35718) |
| trimethoprim (CHEBI:45924) has role antiinfective agent (CHEBI:35441) |
| trimethoprim (CHEBI:45924) has role antimalarial (CHEBI:38068) |
| trimethoprim (CHEBI:45924) has role antimicrobial agent (CHEBI:33281) |
| trimethoprim (CHEBI:45924) has role antineoplastic agent (CHEBI:35610) |
| trimethoprim (CHEBI:45924) has role antitubercular agent (CHEBI:33231) |
| trimethoprim (CHEBI:45924) has role dermatologic drug (CHEBI:50177) |
| trimethoprim (CHEBI:45924) has role diuretic (CHEBI:35498) |
| trimethoprim (CHEBI:45924) has role drug allergen (CHEBI:88188) |
| trimethoprim (CHEBI:45924) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683) |
| trimethoprim (CHEBI:45924) has role environmental contaminant (CHEBI:78298) |
| trimethoprim (CHEBI:45924) has role hypoglycemic agent (CHEBI:35526) |
| trimethoprim (CHEBI:45924) has role ophthalmology drug (CHEBI:66981) |
| trimethoprim (CHEBI:45924) has role renoprotective agent (CHEBI:231911) |
| trimethoprim (CHEBI:45924) has role xenobiotic (CHEBI:35703) |
| trimethoprim (CHEBI:45924) is a aminopyrimidine (CHEBI:38338) |
| trimethoprim (CHEBI:45924) is a methoxybenzenes (CHEBI:51683) |
| Incoming Relation(s) |
| 6-chlorotrimethoprim (CHEBI:351351) has functional parent trimethoprim (CHEBI:45924) |
| 6-hydroxytrimethoprim (CHEBI:58969) has functional parent trimethoprim (CHEBI:45924) |
| co-trimoxazole (CHEBI:3770) has part trimethoprim (CHEBI:45924) |
| 5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl group (CHEBI:55508) is substituent group from trimethoprim (CHEBI:45924) |
| IUPAC Name |
|---|
| 5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine |
| INNs | Source |
|---|---|
| trimethoprime | WHO MedNet |
| trimetoprima | WHO MedNet |
| Synonyms | Source |
|---|---|
| 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine | NIST Chemistry WebBook |
| 5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine | NIST Chemistry WebBook |
| BW 56-72 | ChEMBL |
| BW-56-72 | ChEMBL |
| Infectotrimet | ChEMBL |
| NIH-204 | ChEMBL |
| Brand Names | Source |
|---|---|
| Ipral | ChEMBL |
| Ledatrim | ChEMBL |
| Monotrim | ChEMBL |
| Proloprin | ChEMBL |
| Syraprim | ChEMBL |
| Tiempe | ChEMBL |
| Manual Xrefs | Databases |
|---|---|
| 1745 | VSDB |
| 2755 | DrugCentral |
| C01965 | KEGG COMPOUND |
| D00145 | KEGG DRUG |
| DB00440 | DrugBank |
| HMDB0014583 | HMDB |
| LSM-5246 | LINCS |
| TOP | PDBeChem |
| Trimethoprim | Wikipedia |
| Citations |
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