› › Structure analysis

An atomic structure of the human 26S proteasome

Electron Microscopy
3.5Å resolution
PDB entry 5gjr coloured by chain, front view.
PDB entry 5gjr coloured by chain, side view.
PDB entry 5gjr coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero 64-mer (preferred)
Entry contents: 32 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: 20S proteasome complex and Proteasome complex
hide full assembly name
Multimeric state: hetero 64-mer
Accessible surface area: 733916.2 Å2
Buried surface area: 299959.29 Å2
Dissociation area: 2,634.56 Å2
Dissociation energy (ΔGdiss): 24.68 kcal/mol
Dissociation entropy (TΔSdiss): 23.14 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-126191

Macromolecules

26S proteasome regulatory subunit 4
Chains: I, w
Length: 440 amino acids
Theoretical weight: 49.26 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62191 (Residues: 1-440; Coverage: 100%)
Gene name: PSMC1
Pfam:
InterPro:
26S proteasome regulatory subunit 4 in PDB entry 5gjr, assembly 1, front view.
26S proteasome regulatory subunit 4 in PDB entry 5gjr, assembly 1, side view.
26S proteasome regulatory subunit 4 in PDB entry 5gjr, assembly 1, top view.
Molecule details ›

Search similar proteins

26S proteasome regulatory subunit 7
Chains: H, v
Length: 433 amino acids
Theoretical weight: 48.7 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P35998 (Residues: 1-433; Coverage: 100%)
Gene names: MSS1, PSMC2
Pfam:
InterPro:
26S proteasome regulatory subunit 7 in PDB entry 5gjr, assembly 1, front view.
26S proteasome regulatory subunit 7 in PDB entry 5gjr, assembly 1, side view.
26S proteasome regulatory subunit 7 in PDB entry 5gjr, assembly 1, top view.
Molecule details ›

Search similar proteins

26S proteasome regulatory subunit 10B
Chains: L, z
Length: 389 amino acids
Theoretical weight: 44.24 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62333 (Residues: 1-389; Coverage: 100%)
Gene names: PSMC6, SUG2
Pfam:
InterPro:
26S proteasome regulatory subunit 10B in PDB entry 5gjr, assembly 1, front view.
26S proteasome regulatory subunit 10B in PDB entry 5gjr, assembly 1, side view.
26S proteasome regulatory subunit 10B in PDB entry 5gjr, assembly 1, top view.
Molecule details ›

Search similar proteins

26S proteasome regulatory subunit 6A
Chains: 0, M
Length: 439 amino acids
Theoretical weight: 49.27 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P17980 (Residues: 1-439; Coverage: 100%)
Gene names: PSMC3, TBP1
Pfam:
InterPro:
26S proteasome regulatory subunit 6A in PDB entry 5gjr, assembly 1, front view.
26S proteasome regulatory subunit 6A in PDB entry 5gjr, assembly 1, side view.
26S proteasome regulatory subunit 6A in PDB entry 5gjr, assembly 1, top view.
Molecule details ›

Search similar proteins

26S proteasome regulatory subunit 8
Chains: J, x
Length: 406 amino acids
Theoretical weight: 45.69 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62195 (Residues: 1-406; Coverage: 100%)
Gene names: PSMC5, SUG1
Pfam:
InterPro:
26S proteasome regulatory subunit 8 in PDB entry 5gjr, assembly 1, front view.
26S proteasome regulatory subunit 8 in PDB entry 5gjr, assembly 1, side view.
26S proteasome regulatory subunit 8 in PDB entry 5gjr, assembly 1, top view.
Molecule details ›

Search similar proteins

26S proteasome regulatory subunit 6B
Chains: K, y
Length: 418 amino acids
Theoretical weight: 47.43 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P43686 (Residues: 1-418; Coverage: 100%)
Gene names: MIP224, PSMC4, TBP7
Pfam:
InterPro:
26S proteasome regulatory subunit 6B in PDB entry 5gjr, assembly 1, front view.
26S proteasome regulatory subunit 6B in PDB entry 5gjr, assembly 1, side view.
26S proteasome regulatory subunit 6B in PDB entry 5gjr, assembly 1, top view.
Molecule details ›

Search similar proteins

26S proteasome non-ATPase regulatory subunit 1
Chains: 1, N
Length: 953 amino acids
Theoretical weight: 105.96 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q99460 (Residues: 1-953; Coverage: 100%)
Gene name: PSMD1
Pfam:
InterPro:
26S proteasome non-ATPase regulatory subunit 1 in PDB entry 5gjr, assembly 1, front view.
26S proteasome non-ATPase regulatory subunit 1 in PDB entry 5gjr, assembly 1, side view.
26S proteasome non-ATPase regulatory subunit 1 in PDB entry 5gjr, assembly 1, top view.
Molecule details ›

Search similar proteins

26S proteasome non-ATPase regulatory subunit 13
Chains: 2, O
Length: 376 amino acids
Theoretical weight: 43 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9UNM6 (Residues: 1-376; Coverage: 100%)
Gene name: PSMD13
Pfam:
InterPro:
26S proteasome non-ATPase regulatory subunit 13 in PDB entry 5gjr, assembly 1, front view.
26S proteasome non-ATPase regulatory subunit 13 in PDB entry 5gjr, assembly 1, side view.
26S proteasome non-ATPase regulatory subunit 13 in PDB entry 5gjr, assembly 1, top view.
Molecule details ›

Search similar proteins

26S proteasome non-ATPase regulatory subunit 12
Chains: 3, P
Length: 456 amino acids
Theoretical weight: 52.98 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O00232 (Residues: 1-456; Coverage: 100%)
Gene name: PSMD12
Pfam:
InterPro:
26S proteasome non-ATPase regulatory subunit 12 in PDB entry 5gjr, assembly 1, front view.
26S proteasome non-ATPase regulatory subunit 12 in PDB entry 5gjr, assembly 1, side view.
26S proteasome non-ATPase regulatory subunit 12 in PDB entry 5gjr, assembly 1, top view.
Molecule details ›

Search similar proteins

26S proteasome non-ATPase regulatory subunit 11
Chains: 4, Q
Length: 422 amino acids
Theoretical weight: 47.53 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O00231 (Residues: 1-422; Coverage: 100%)
  • Best match: O00231-2 (Residues: 1-423)
Gene name: PSMD11
Pfam:
InterPro:
26S proteasome non-ATPase regulatory subunit 11 in PDB entry 5gjr, assembly 1, front view.
26S proteasome non-ATPase regulatory subunit 11 in PDB entry 5gjr, assembly 1, side view.
26S proteasome non-ATPase regulatory subunit 11 in PDB entry 5gjr, assembly 1, top view.
Molecule details ›

Search similar proteins

26S proteasome non-ATPase regulatory subunit 6
Chains: 5, R
Length: 389 amino acids
Theoretical weight: 45.59 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q15008 (Residues: 1-389; Coverage: 100%)
Gene names: KIAA0107, PFAAP4, PSMD6
Pfam:
InterPro:
26S proteasome non-ATPase regulatory subunit 6 in PDB entry 5gjr, assembly 1, front view.
26S proteasome non-ATPase regulatory subunit 6 in PDB entry 5gjr, assembly 1, side view.
26S proteasome non-ATPase regulatory subunit 6 in PDB entry 5gjr, assembly 1, top view.
Molecule details ›

Search similar proteins

26S proteasome non-ATPase regulatory subunit 3
Chains: 6, S
Length: 525 amino acids
Theoretical weight: 60.07 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O43242 (Residues: 1-525; Coverage: 98%)
Gene name: PSMD3
Pfam:
InterPro:
26S proteasome non-ATPase regulatory subunit 3 in PDB entry 5gjr, assembly 1, front view.
26S proteasome non-ATPase regulatory subunit 3 in PDB entry 5gjr, assembly 1, side view.
26S proteasome non-ATPase regulatory subunit 3 in PDB entry 5gjr, assembly 1, top view.
Molecule details ›

Search similar proteins

26S proteasome non-ATPase regulatory subunit 8
Chains: 7, T
Length: 350 amino acids
Theoretical weight: 39.67 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P48556 (Residues: 1-350; Coverage: 100%)
Gene name: PSMD8
Pfam: CSN8/PSMD8/EIF3K family
InterPro:
26S proteasome non-ATPase regulatory subunit 8 in PDB entry 5gjr, assembly 1, front view.
26S proteasome non-ATPase regulatory subunit 8 in PDB entry 5gjr, assembly 1, side view.
26S proteasome non-ATPase regulatory subunit 8 in PDB entry 5gjr, assembly 1, top view.
Molecule details ›

Search similar proteins

26S proteasome non-ATPase regulatory subunit 7
Chains: 8, U
Length: 324 amino acids
Theoretical weight: 37.09 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P51665 (Residues: 1-324; Coverage: 100%)
Gene names: MOV34L, PSMD7
Pfam:
InterPro:
26S proteasome non-ATPase regulatory subunit 7 in PDB entry 5gjr, assembly 1, front view.
26S proteasome non-ATPase regulatory subunit 7 in PDB entry 5gjr, assembly 1, side view.
26S proteasome non-ATPase regulatory subunit 7 in PDB entry 5gjr, assembly 1, top view.
Molecule details ›

Search similar proteins

26S proteasome non-ATPase regulatory subunit 14
Chains: 9, V
Length: 310 amino acids
Theoretical weight: 34.62 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O00487 (Residues: 1-310; Coverage: 100%)
Gene names: POH1, PSMD14
Pfam: JAB1/Mov34/MPN/PAD-1 ubiquitin protease
InterPro:
26S proteasome non-ATPase regulatory subunit 14 in PDB entry 5gjr, assembly 1, front view.
26S proteasome non-ATPase regulatory subunit 14 in PDB entry 5gjr, assembly 1, side view.
26S proteasome non-ATPase regulatory subunit 14 in PDB entry 5gjr, assembly 1, top view.
Molecule details ›

Search similar proteins

26S proteasome non-ATPase regulatory subunit 4
Chains: AA, W
Length: 377 amino acids
Theoretical weight: 40.78 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P55036 (Residues: 1-377; Coverage: 100%)
Gene names: MCB1, PSMD4
Pfam:
InterPro:
26S proteasome non-ATPase regulatory subunit 4 in PDB entry 5gjr, assembly 1, front view.
26S proteasome non-ATPase regulatory subunit 4 in PDB entry 5gjr, assembly 1, side view.
26S proteasome non-ATPase regulatory subunit 4 in PDB entry 5gjr, assembly 1, top view.
Molecule details ›

Search similar proteins

26S proteasome complex subunit SEM1
Chains: AB, Y
Length: 70 amino acids
Theoretical weight: 8.28 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P60896 (Residues: 1-70; Coverage: 100%)
Gene names: C7orf76, DSS1, SEM1, SHFDG1, SHFM1
Pfam: DSS1/SEM1 family
InterPro: DSS1/SEM1
26S proteasome complex subunit SEM1 in PDB entry 5gjr, assembly 1, front view.
26S proteasome complex subunit SEM1 in PDB entry 5gjr, assembly 1, side view.
26S proteasome complex subunit SEM1 in PDB entry 5gjr, assembly 1, top view.
Molecule details ›

Search similar proteins

26S proteasome non-ATPase regulatory subunit 2
Chains: AC, Z
Length: 908 amino acids
Theoretical weight: 100.31 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q13200 (Residues: 1-908; Coverage: 100%)
Gene names: PSMD2, TRAP2
Pfam:
InterPro:
26S proteasome non-ATPase regulatory subunit 2 in PDB entry 5gjr, assembly 1, front view.
26S proteasome non-ATPase regulatory subunit 2 in PDB entry 5gjr, assembly 1, side view.
26S proteasome non-ATPase regulatory subunit 2 in PDB entry 5gjr, assembly 1, top view.
Molecule details ›

Search similar proteins

Proteasome subunit alpha type-6
Chains: B, h
Length: 246 amino acids
Theoretical weight: 27.43 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P60900 (Residues: 1-246; Coverage: 100%)
Gene names: PROS27, PSMA6
Pfam:
InterPro:
Proteasome subunit alpha type-6 in PDB entry 5gjr, assembly 1, front view.
Proteasome subunit alpha type-6 in PDB entry 5gjr, assembly 1, side view.
Proteasome subunit alpha type-6 in PDB entry 5gjr, assembly 1, top view.
Molecule details ›

Search similar proteins

Proteasome subunit alpha type-2
Chains: C, i
Length: 234 amino acids
Theoretical weight: 25.93 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P25787 (Residues: 1-234; Coverage: 100%)
Gene names: HC3, PSC3, PSMA2
Pfam:
InterPro:
Proteasome subunit alpha type-2 in PDB entry 5gjr, assembly 1, front view.
Proteasome subunit alpha type-2 in PDB entry 5gjr, assembly 1, side view.
Proteasome subunit alpha type-2 in PDB entry 5gjr, assembly 1, top view.
Molecule details ›

Search similar proteins

Proteasome subunit alpha type-4
Chains: D, j
Length: 261 amino acids
Theoretical weight: 29.53 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P25789 (Residues: 1-261; Coverage: 100%)
Gene names: HC9, PSC9, PSMA4
Pfam:
InterPro:
Proteasome subunit alpha type-4 in PDB entry 5gjr, assembly 1, front view.
Proteasome subunit alpha type-4 in PDB entry 5gjr, assembly 1, side view.
Proteasome subunit alpha type-4 in PDB entry 5gjr, assembly 1, top view.
Molecule details ›

Search similar proteins

Proteasome subunit alpha type-7
Chains: E, k
Length: 248 amino acids
Theoretical weight: 27.93 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O14818 (Residues: 1-248; Coverage: 100%)
Gene names: HSPC, PSMA7
Pfam:
InterPro:
Proteasome subunit alpha type-7 in PDB entry 5gjr, assembly 1, front view.
Proteasome subunit alpha type-7 in PDB entry 5gjr, assembly 1, side view.
Proteasome subunit alpha type-7 in PDB entry 5gjr, assembly 1, top view.
Molecule details ›

Search similar proteins

Proteasome subunit alpha type-5
Chains: F, l
Length: 241 amino acids
Theoretical weight: 26.44 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P28066 (Residues: 1-241; Coverage: 100%)
Gene name: PSMA5
Pfam:
InterPro:
Proteasome subunit alpha type-5 in PDB entry 5gjr, assembly 1, front view.
Proteasome subunit alpha type-5 in PDB entry 5gjr, assembly 1, side view.
Proteasome subunit alpha type-5 in PDB entry 5gjr, assembly 1, top view.
Molecule details ›

Search similar proteins

Proteasome subunit alpha type-1
Chains: G, m
Length: 263 amino acids
Theoretical weight: 29.6 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P25786 (Residues: 1-263; Coverage: 100%)
Gene names: HC2, NU, PROS30, PSC2, PSMA1
Pfam:
InterPro:
Proteasome subunit alpha type-1 in PDB entry 5gjr, assembly 1, front view.
Proteasome subunit alpha type-1 in PDB entry 5gjr, assembly 1, side view.
Proteasome subunit alpha type-1 in PDB entry 5gjr, assembly 1, top view.
Molecule details ›

Search similar proteins

Proteasome subunit alpha type-3
Chains: X, n
Length: 255 amino acids
Theoretical weight: 28.47 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P25788 (Residues: 1-255; Coverage: 100%)
Gene names: HC8, PSC8, PSMA3
Pfam:
InterPro:
Proteasome subunit alpha type-3 in PDB entry 5gjr, assembly 1, front view.
Proteasome subunit alpha type-3 in PDB entry 5gjr, assembly 1, side view.
Proteasome subunit alpha type-3 in PDB entry 5gjr, assembly 1, top view.
Molecule details ›

Search similar proteins

Proteasome subunit beta type-6
Chains: a, o
Length: 239 amino acids
Theoretical weight: 25.38 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P28072 (Residues: 1-239; Coverage: 100%)
Gene names: LMPY, PSMB6, Y
Pfam: Proteasome subunit
InterPro:
Proteasome subunit beta type-6 in PDB entry 5gjr, assembly 1, front view.
Proteasome subunit beta type-6 in PDB entry 5gjr, assembly 1, side view.
Proteasome subunit beta type-6 in PDB entry 5gjr, assembly 1, top view.
Molecule details ›

Search similar proteins

Proteasome subunit beta type-7
Chains: b, p
Length: 277 amino acids
Theoretical weight: 30 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q99436 (Residues: 1-277; Coverage: 100%)
Gene names: PSMB7, Z
Pfam:
InterPro:
Proteasome subunit beta type-7 in PDB entry 5gjr, assembly 1, front view.
Proteasome subunit beta type-7 in PDB entry 5gjr, assembly 1, side view.
Proteasome subunit beta type-7 in PDB entry 5gjr, assembly 1, top view.
Molecule details ›

Search similar proteins

Proteasome subunit beta type-3
Chains: c, q
Length: 205 amino acids
Theoretical weight: 22.97 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P49720 (Residues: 1-205; Coverage: 100%)
Gene name: PSMB3
Pfam: Proteasome subunit
InterPro:
Proteasome subunit beta type-3 in PDB entry 5gjr, assembly 1, front view.
Proteasome subunit beta type-3 in PDB entry 5gjr, assembly 1, side view.
Proteasome subunit beta type-3 in PDB entry 5gjr, assembly 1, top view.
Molecule details ›

Search similar proteins

Proteasome subunit beta type-2
Chains: d, r
Length: 201 amino acids
Theoretical weight: 22.86 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P49721 (Residues: 1-201; Coverage: 100%)
Gene name: PSMB2
Pfam: Proteasome subunit
InterPro:
Proteasome subunit beta type-2 in PDB entry 5gjr, assembly 1, front view.
Proteasome subunit beta type-2 in PDB entry 5gjr, assembly 1, side view.
Proteasome subunit beta type-2 in PDB entry 5gjr, assembly 1, top view.
Molecule details ›

Search similar proteins

Proteasome subunit beta type-5
Chains: e, s
Length: 263 amino acids
Theoretical weight: 28.51 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P28074 (Residues: 1-263; Coverage: 100%)
Gene names: LMPX, MB1, PSMB5, X
Pfam: Proteasome subunit
InterPro:
Proteasome subunit beta type-5 in PDB entry 5gjr, assembly 1, front view.
Proteasome subunit beta type-5 in PDB entry 5gjr, assembly 1, side view.
Proteasome subunit beta type-5 in PDB entry 5gjr, assembly 1, top view.
Molecule details ›

Search similar proteins

Proteasome subunit beta type-1
Chains: f, t
Length: 241 amino acids
Theoretical weight: 26.52 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P20618 (Residues: 1-241; Coverage: 100%)
Gene names: PSC5, PSMB1
Pfam: Proteasome subunit
InterPro:
Proteasome subunit beta type-1 in PDB entry 5gjr, assembly 1, front view.
Proteasome subunit beta type-1 in PDB entry 5gjr, assembly 1, side view.
Proteasome subunit beta type-1 in PDB entry 5gjr, assembly 1, top view.
Molecule details ›

Search similar proteins

Proteasome subunit beta type-4
Chains: g, u
Length: 264 amino acids
Theoretical weight: 29.23 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P28070 (Residues: 1-264; Coverage: 100%)
Gene names: PROS26, PSMB4
Pfam: Proteasome subunit
InterPro:
Proteasome subunit beta type-4 in PDB entry 5gjr, assembly 1, front view.
Proteasome subunit beta type-4 in PDB entry 5gjr, assembly 1, side view.
Proteasome subunit beta type-4 in PDB entry 5gjr, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links