Family

Proteasome subunit alpha6 (IPR034642)

Short name: Proteasome_subunit_alpha6

Family relationships

Description

The proteasome (or macropain) (EC:3.4.25.1) [PMID: 7682410, PMID: 2643381, PMID: 1317508, PMID: 7697118, PMID: 8882582] is a multicatalytic proteinase complex in eukaryotes and archaea, and in some bacteria, that is involved in an ATP/ubiquitin-dependent non-lysosomal proteolytic pathway. In eukaryotes the 20S proteasome is composed of 28 distinct subunits which form a highly ordered ring-shaped structure (20S ring) of about 700 kDa. Proteasome subunits can be classified on the basis of sequence similarities into two groups, alpha (A) and beta (B). The proteasome consists of four stacked rings composed of alpha/beta/beta/alpha subunits. There are seven different alpha subunits and seven different beta subunits [PMID: 9087403]. Three of the seven beta subunits are peptidases, each with a different specificity. Subunit beta1c (MEROPS identifier T01.010) has a preference for cleaving glutaminyl bonds ("peptidyl-glutamyl-like" or "caspase-like"), subunit beta2c (MEROPS identifier T01.011) has a preference for cleaving arginyl and lysyl bonds ("trypsin-like"), and subunit beta5c (MEROPS identifier T01.012) cleaves after hydrophobic amino acids ("chymotrypsin-like") [PMID: 2535672]. The proteasome subunits are related to N-terminal nucleophile hydrolases, and the catalytic subunits have an N-terminal threonine nucleophile.

This entry includes the non-proteolytic alpha6 subunit of the 19S proteasome (MEROPS identifier T01.971). The equivalent subunit in Saccharomyces cerevisiae is known as alpha1. A single nuclear polymorphism is associated with a higher risk of myocardial infarction in a Japanese population, possibly because of an increased risk of atherosclerosis [PMID: 17384448].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0019773 proteasome core complex, alpha-subunit complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD
  • cd03754 (proteasome_alpha_type_6)
PANTHER