Homologous Superfamily

von Willebrand factor A-like domain superfamily (IPR036465)

Short name: vWFA_dom_sf

Overlapping entries


The von Willebrand factor is a large multimeric glycoprotein found in blood plasma. Mutant forms are involved in the aetiology of bleeding disorders [PMID: 8440408]. In von Willebrand factor, the type A domain (vWF) is the prototype for a protein superfamily. The vWF domain is found in various plasma proteins: complement factors B, C2, CR3 and CR4; the integrins (I-domains); collagen types VI, VII, XII and XIV; and other extracellular proteins [PMID: 8412987, PMID: 8145250, PMID: 1864378]. Although the majority of VWA-containing proteins are extracellular, the most ancient ones present in all eukaryotes are all intracellular proteins involved in functions such as transcription, DNA repair, ribosomal and membrane transport and the proteasome. A common feature appears to be involvement in multiprotein complexes. Proteins that incorporate vWF domains participate in numerous biological events (e.g. cell adhesion, migration, homing, pattern formation, and signal transduction), involving interaction with a large array of ligands [PMID: 8412987]. A number of human diseases arise from mutations in VWA domains.

Secondary structure prediction from 75 aligned vWF sequences has revealed a largely alternating sequence of alpha-helices and beta-strands [PMID: 8145250]. The vWF domain fold is predicted to be a doubly-wound, open, twisted beta-sheet flanked by alpha-helices [PMID: 7843416]. 3D structures have been determined for the I-domains of integrins alpha-M (CD11b; with bound magnesium) [PMID: 7867070] and alpha-L (CD11a; with bound manganese) [PMID: 7479767]. The domain adopts a classic alpha/beta Rossmann fold and contains an unusual metal ion coordination site at its surface. It has been suggested that this site represents a general metal ion-dependent adhesion site (MIDAS) for binding protein ligands [PMID: 7867070]. The residues constituting the MIDAS motif in the CD11b and CD11a I-domains are completely conserved, but the manner in which the metal ion is coordinated differs slightly [PMID: 7479767].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.