Domain

Proteasome alpha-subunit, N-terminal domain (IPR000426)

Short name: Proteasome_asu_N

Domain relationships

None.

Description

The proteasome (or macropain) (EC:3.4.25.1) [PMID: 7682410, PMID: 2643381, PMID: 1317508, PMID: 7697118, PMID: 8882582] is a eukaryotic and archaeal multicatalytic proteinase complex that seems to be involved in an ATP/ubiquitin-dependent nonlysosomal proteolytic pathway. In eukaryotes the proteasome is composed of about 28 distinct subunits which form a highly ordered ring-shaped structure (20S ring) of about 700 kDa. Most proteasome subunits can be classified on the basis of sequence similarities into two groups, alpha (A) and beta (B).

Subunits that belong to the A group are proteins of from 210 to 290 amino acids. They are classified as non-peptidase homologues in MEROPS peptidase family T1 (clan PB(T)).

This entry represents an N-terminal domain conserved in the A subunits of the proteasome complex.

GO terms

Biological Process

GO:0006511 ubiquitin-dependent protein catabolic process

Molecular Function

GO:0004175 endopeptidase activity

Cellular Component

GO:0019773 proteasome core complex, alpha-subunit complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PROSITE patterns
SMART