Proteasome subunit beta 4 (IPR016295)

Short name: Proteasome_beta4

Overlapping homologous superfamilies

Family relationships


This group represents the beta type-4 subunit (MEROPS identifier T01.987) from the proteasome endopeptidase complex, which is one of the non-peptidase subunits. This subunit is known as beta type-7 in fungi.

The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of non-lysosomal protein degradation in both the cytosol and nucleus [PMID: 12738238]. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming an elongated alpha-beta-beta-alpha cylinder with a central cavity [PMID: 14675543, PMID: 10410804]. The proteasome alpha and beta subunits are members of the N-terminal nucleophile (Ntn)-hydrolase superfamily [PMID: 11206054]. Three of the beta subunits (beta1, beta2 and beta5) have an N-terminal threonine residue exposed as a nucleophile in peptide bond hydrolysis [PMID: 9207060]. Eukaryotes have 7 alpha and 7 beta proteasome subunits while archaea have one of each [PMID: 12595256].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004298 threonine-type endopeptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.