Proteasome subunit alpha 1 (IPR035144)

Short name: Proteasome_alpha1

Overlapping homologous superfamilies

Family relationships


The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming an elongated alpha-beta-beta-alpha cylinder with a central cavity. The proteasome alpha and beta subunits are members of the N-terminal nucleophile (Ntn)-hydrolase superfamily. Their N-terminal threonine residues are exposed as a nucleophile in peptide bond hydrolysis [PMID: 10410804]. Mammals have 7 alpha and 7 beta proteasome subunits while archaea have one of each.

This entry represents the constitutive proteasome subunit alpha 1 [PMID: 10873386], also known as Prosalpha6 (in Drosophila melanogaster) [PMID: 17728345] and Pre5 or alpha 6 (in fungi) [PMID: 7918444, PMID: 9087403]. This subunit is replaced in the D. melanogaster spermatoproteasome [PMID: 17728345].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0019773 proteasome core complex, alpha-subunit complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
  • cd03749 (proteasome_alpha_type_1)