DSS1/SEM1 (IPR007834)

Short name: DSS1_SEM1

Overlapping homologous superfamilies


Family relationships



This family includes yeast Sem1 and its mammalian homologue, DSS1.

Sem1/DSS1 (also known as rpn15) is a component of lid subcomplex of 26S proteasome regulatory subunit [PMID: 23643786, PMID: 24412063, PMID: 15117943]. Besides being a subunit of the 26S proteasome, Sem1/DSS1 associates with other protein complexes [PMID: 26944332]. It is a component of the nuclear pore complex (NPC)-associated TREX-2 complex that is required for transcription-coupled mRNA export, and the COP9 signalosome, which is involved in deneddylation [PMID: 24896180, PMID: 19289793, PMID: 26456823].

Loss of DSS1 in humans has been associated with split hand/split foot malformations [PMID: 8782053].

GO terms

Biological Process

GO:0006406 mRNA export from nucleus
GO:0043248 proteasome assembly

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0008541 proteasome regulatory particle, lid subcomplex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.