Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P02647

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
18	unknown peptidase	1-267	P	release of a signal peptide	NT	Sharpe et al., 1984
24	procollagen C-peptidase	21-28	P		CS	Chau et al., 2007
42	chymase (Homo sapiens-type)	25-267	P			Andersson et al., 2008
57	chymase (Homo sapiens-type)	25-267	P			Andersson et al., 2008
145	matrix metallopeptidase-7	25-267	P	normal turnover		Lindstedt et al., 1999
145	matrix metallopeptidase-12	25-267	P	normal turnover		Lindstedt et al., 1999
149	matrix metallopeptidase-3	25-267	P	normal turnover		Lindstedt et al., 1999
215	matrix metallopeptidase-3	25-267	P	normal turnover		Lindstedt et al., 1999
215	matrix metallopeptidase-12	25-267	P	normal turnover		Lindstedt et al., 1999
223	matrix metallopeptidase-12	25-267	P	normal turnover		Lindstedt et al., 1999
226	matrix metallopeptidase-7	25-267	P	normal turnover		Lindstedt et al., 1999
237	matrix metallopeptidase-7	25-267	P	normal turnover		Lindstedt et al., 1999
237	matrix metallopeptidase-12	25-267	P	normal turnover		Lindstedt et al., 1999
249	matrix metallopeptidase-12	25-267	P	normal turnover		Lindstedt et al., 1999
249	chymase (Homo sapiens-type)	1-267	P			Lee et al., 2003
249	transthyretin	25-267	P		NT	Lis et al., 2004
266	unknown peptidase	1-267	P		NT	<%Agarwal et al., 2012[]%>