Substrates for peptidase S11.008: penicillin-binding protein 5-type peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Ala-gamma-D-Glu-Lys-D-Ala-D-Ala Ala-gamma-D-Glu-Lys-D-Ala+D-Ala S GDG DGl Lys DAl DAl - - - Chowdhury %eyal, 2010
diacetyl-Lys-D-Ala-D-Ala diacetyl-Lys-D-Ala+D-Ala S - Ac2 Lys DAl DAl - - - Anderson et al., 2003
epsilon-aminohexanoyl-D-Ala-D-Ala epsilon-aminohexanoyl-D-Ala+D-Ala S - - Hex DAl DAl - - - Anderson et al., 2003
Gly-alpha-aminopimelyl-epsilon-D-Ala-D-Ala Gly-alpha-aminopimelyl-epsilon-D-Ala+D-Ala S - Gly API DAl DAl - - - Anderson et al., 2003
N-acetylglucosamine-N-acetylmuramoyl-Ala-D-Glu-Lys-Ala-D-Ala N-acetylglucosamine-N-acetylmuramoyl-Ala-D-Glu-Lys-Ala-D-Ala S Ala DGl Lys Ala DAl - - - Hesek et al., 2004
N-acetylglucosamine-N-acetylmuramoyl-Ala-D-Glu-meso-diaminopimelate-Ala+D-Ala N-acetylglucosamine-N-acetylmuramoyl-Ala-D-Glu-meso-diaminopimelate-Ala+D-Ala P Ala DGl Dpm Ala DAl - - - Hesek et al., 2004
N-acetylmuramoyl-Ala-D-Glu-Lys-Ala-D-Ala N-acetylmuramoyl-Ala-D-Glu-Lys-Ala+D-Ala S Ala DGl Lys Ala DAl - - - Hesek et al., 2004