Substrates for peptidase S09.019: dipeptidyl-peptidase 9

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Ala-Pro-7-amido-4-trifluoromethylcoumarin Ala-Pro+7-amido-4-trifluoromethylcoumarin S - - Ala Pro FMC - - - Ajami et al., 2004
Ala-Pro-NHPhNO2 Ala-Pro+NHPhNO2 S - - Ala Pro NAN - - - Bjelke et al., 2006
Arg-Pro-NHPhNO2 Arg-Pro+NHPhNO2 S - - Arg Pro NAN - - - Bjelke et al., 2006
Asp-Pro-NHMec Asp-Pro+NHMec S - - Asp Pro AMC - - - Geiss-Friedlander et al., 2009
glucagon-like peptide 1 His-Ala+Glu-peptide N - - His Ala Glu Gly Thr Phe Bjelke et al., 2006
glucagon-like peptide 2 His-Ala-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-Asn-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp N - - His Ala Asp Gly Ser Phe Bjelke et al., 2006
Gly-Pro-7-amido-4-trifluoromethylcoumarin Gly-Pro+7-amido-4-trifluoromethylcoumarin S - - Gly Pro FMC - - - Ajami et al., 2004
Gly-Pro-NHMec Gly-Pro+NHMec S - - Gly Pro AMC - - - Geiss-Friedlander et al., 2009
Gly-Pro-NHPhNO2 Gly-Pro+NHPhNO2 S - - Gly Pro NAN - - - Bjelke et al., 2006
Lys-Pro-NHMec Lys-Pro+NHMec S - - Lys Pro AMC - - - Geiss-Friedlander et al., 2009
neuropeptide Y Tyr-Pro+Ser-peptide N - - Tyr Pro Ser Lys Pro Asp Bjelke et al., 2006
peptide YY Tyr-Pro+Ile-Leu-Lys-Pro-Gly-Glu-Ala-Pro-Gly-Gly-Glu-Asp-Ala-Ser-Pro-Gly-Glu-Gly-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-VTArg-Gln-Arg-Tyr-NH2 N - - Tyr Pro Ile Leu Lys Pro Bjelke et al., 2006
RU1 antigenic peptide Q9UHJ3 34-42 Val-Pro+Tyr-Gly-Ser-Phe-Lys-His-Val P - - Val Pro Tyr Gly Ser Phe Geiss-Friedlander et al., 2009
Trp-Pro-NHMec Trp-Pro+NHMec S - - Trp Pro AMC - - - Geiss-Friedlander et al., 2009
Val-Pro-NHMec Val-Pro+NHMec S - - Val Pro AMC - - - Geiss-Friedlander et al., 2009