Substrates for peptidase S01.257: kallikrein-related peptidase 11

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Gln-Ala-Arg-NHMec			Gln-Ala-Arg+NHMec	S		-	Gln	Ala	Arg	AMC	-	-	-	Luo et al., 2006
Gly-Pro-Arg-NHMec			Gly-Pro-Arg+NHMec	S		-	Gly	Pro	Arg	AMC	-	-	-	Luo et al., 2006
Kallikrein-1 precursor	P06870	19-262	peptide-Arg24+Ile-peptide	P	NT	Ile	Gln	Ser	Arg	Ile	Val	Gly	Gly	Yoon et al., 2007
Kallikrein-11 precursor	Q9UBX7	51-282	Glu-Thr-Arg53+Ile-peptide	P	NT	-	Glu	Thr	Arg	Ile	Ile	Lys	Gly	Yoon et al., 2007
Kallikrein-12 precursor	Q9UKR0	18-248	Ala-Thr-Pro-Lys21+Ile-peptide	P	NT	Ala	Thr	Pro	Lys	Ile	Phe	Asn	Gly	Yoon et al., 2007
Kallikrein-14 precursor	Q9P0G3	35-267	peptide-Lys40+Ile-peptide	P	NT	Asp	Glu	Asn	Lys	Ile	Ile	Gly	Gly	Yoon et al., 2007
Kallikrein-4 precursor	Q9Y5K2	27-254	Ser-Cys-Ser-Gln30+Ile-peptide	P	NT	Ser	Cys	Ser	Gln	Ile	Ile	Asn	Gly	Yoon et al., 2007
Kallikrein-5 precursor	Q9Y337	23-293	peptide-Arg66+Ile-peptide	P	NT	Ser	Ser	Ser	Arg	Ile	Ile	Asn	Gly	Yoon et al., 2007
Kallikrein-6 precursor	Q92876	17-244	peptide-Lys21+Leu-peptide	P	NT	Glu	Gln	Asn	Lys	Leu	Val	His	Gly	Yoon et al., 2007
Phe-Ser-Arg-NHMec			Phe-Ser-Arg+NHMec	S		-	Phe	Ser	Arg	AMC	-	-	-	Luo et al., 2006
Pro-Phe-Arg-NHMec			Pro-Phe-Arg+NHMec	S		-	Pro	Phe	Arg	AMC	-	-	-	Yamaguchi, 2004
Prostate-specific antigen precursor	P07288	18-261	peptide-Arg24+Ile-peptide	P	NT	Ile	Leu	Ser	Arg	Ile	Val	Gly	Gly	Yoon et al., 2007
Val-Pro-Arg-NHMec			Val-Pro-Arg+NHMec	S		-	Val	Pro	Arg	AMC	-	-	-	Luo et al., 2006
Z-Leu-Arg-NHMec			Z-Leu-Arg+NHMec	S		-	Z	Leu	Arg	AMC	-	-	-	Debela et al., 2006
Z-Phe-Arg-Mca			Z-Phe-Arg+Mca	S		-	Z	Phe	Arg	Mca	-	-	-	Mitsui et al., 2000
Z-Phe-Arg-NHMec			Z-Phe-Arg+NHMec	S		-	Z	Phe	Arg	AMC	-	-	-	Yamaguchi, 2004