$VAR1 = undef;

Summary for peptidase S01.257: kallikrein-related peptidase 11

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

 

Names
MEROPS Namekallikrein-related peptidase 11
Other nameshippostasin, kallikrein 11, KLK11 g.p. (Homo sapiens), TLSP peptidase, PRSS20 [obs.] g.p. (Homo sapiens), kallikrein 11 (Homo sapiens), kallikrein 11-like peptidase (Mus musculus )
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.257
Holotypekallikrein-related peptidase 11 (Homo sapiens), Uniprot accession Q9UBX7 (peptidase unit: 54-282), MERNUM MER0004861
History Identifier created: MEROPS 3.1 (22 December 1998)
Activity
Catalytic typeSerine
NC-IUBMBNot yet included in IUBMB recommendations.
Activity statushuman: active (Yamaguchi, 2004)
mouse: active (by similarity to human)
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/KLK11
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/sfp/RkqScissile bondI/ivf/gn/G (based on 16 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 1 0 0 0 0 3 8
Pro 0 1 3 0 0 0 0 0
Ala 1 0 1 0 0 0 0 0
Val 0 1 0 0 0 3 0 0
Leu 0 1 1 0 1 0 0 0
Ile 2 0 0 0 7 4 0 0
Met 0 0 0 0 0 0 0 0
Phe 0 1 3 0 0 1 0 0
Tyr 0 0 0 0 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 2 1 5 0 0 0 0 0
Thr 0 1 1 0 0 0 0 0
Cys 0 1 0 0 0 0 0 0
Asn 0 0 2 0 0 0 3 0
Gln 0 3 0 1 0 0 0 0
Asp 1 0 0 0 0 0 0 0
Glu 1 2 0 0 0 0 0 0
Lys 0 0 0 3 0 0 1 0
Arg 0 0 0 12 0 0 0 0
His 0 0 0 0 0 0 1 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
KLK11 19q13.3-q13.4 ENSG00000167757 11012 KLK11 604434
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Prss20 7:B2 ENSMUSG00000030693 56538 MGI:1929977