Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase S01.257: kallikrein-related peptidase 11

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

(Topics flags: A Assay, P Specificity, R Splicing, K Knockout, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Kondaparthi,V., Malkhed,V., Damera,T., Bingi,M.L., Gangidi,P. and Mustyala,K.K.
    An In Silico Design, Simulation, Virtual Screening, and Evaluation of Natural Products as Inhibitors of Breast Cancer-Causing Kallikrein11 Protein and Comparison of Binding Affinities with Approved Drugs
    Curr Drug Targets (2026) PubMed  Europe PubMed DOI  I
    2. 2023
  2. Gong,Z., Dai,S., Jiang,X., Lee,M., Zhu,X., Wang,H. and Lin,Z.
    Variants in KLK11, affecting signal peptide cleavage of kallikrein-related peptidase 11, cause an autosomal-dominant cornification disorder
    Br J Dermatol (2023) 188, 100-111. PubMed  Europe PubMed DOI
  3. Stuardo-Parada,A., Lopez-Munoz,R., Villarroel-Espindola,F., Figueroa,C.D. and Ehrenfeld,P.
    Minireview: functional roles of tissue kallikrein, kinins, and kallikrein-related peptidases in lung cancer
    Med Oncol (2023) 40, 224-224. PubMed  Europe PubMed DOI  V
    4. 2021
  4. Zhao,R., Wang,S., Liu,J., Xu,C., Zhang,S., Shao,Y. and Duan,X.
    KLK11 acts as a tumor-inhibitor in laryngeal squamous cell carcinoma through the inactivation of Akt/Wnt/beta-catenin signaling
    J Bioenerg Biomembr (2021) 53, 85-96. PubMed  Europe PubMed DOI  K
    5. 2019
  5. He,X., Meng,F., Qin,L., Liu,Z., Zhu,X., Yu,Z. and Zheng,Y.
    KLK11 suppresses cellular proliferation via inhibition of Wnt/beta-catenin signaling pathway in esophageal squamous cell carcinoma
    Am J Cancer Res (2019) 9, 2264-2277. PubMed  Europe PubMed  PMC  EPMC
    6. 2018
  6. Adamopoulos,P.G., Kontos,C.K. and Scorilas,A.
    Novel splice variants of the human kallikrein-related peptidases 11 (KLK11) and 12 (KLK12), unraveled by Next-Generation Sequencing technology
    Biol Chem (2018) 399, 1065-1071. PubMed  Europe PubMed DOI  R
    7. 2016
  7. Karakosta,T.D., Soosaipillai,A., Diamandis,E.P., Batruch,I. and Drabovich,A.P.
    Quantification of human kallikrein-related peptidases in biological fluids by multiplatform targeted mass spectrometry assays
    Mol Cell Proteomics (2016) 15, 2863-2876. PubMed  Europe PubMed DOI  A
    8. 2015
  8. Angelopoulou,K. and Karagiannis,G.S.
    Identification, molecular characterization and alternative splicing of three novel members of the canine kallikrein (Klk)-related peptidase family
    Anticancer Res (2015) 35, 2715-2723. PubMed  Europe PubMed
    9. 2013
  9. Lundwall,A.
    Old genes and new genes: The evolution of the kallikrein locus
    Thromb Haemost (2013) 110, 469-475. PubMed  Europe PubMed DOI  V
    10. 2012
  10. Clements,J.A., Hooper,J.D. and Dong,Y.
    The human tissue kallikrein and kallikrein-related peptidase family
    [ISSN:978-0-12-407742-3] (2012) 3, 2747-2756. DOI
  11. Yamaguchi,N.
    Human kallikrein 11 or hippostasin
    [ISSN:978-0-12-407742-3] (2012) 3, 2802-2805. DOI
    12. 2008
  12. Clements,J.A.
    Reflections on the tissue kallikrein and kallikrein-related peptidase family - from mice to men - what have we learnt in the last two decades?
    Biol Chem (2008) 389, 1447-1454. PubMed  Europe PubMed DOI  V
  13. Yoon,H., Blaber,S.I., Evans,D.M., Trim,J., Juliano,M.A., Scarisbrick,I.A. and Blaber,M.
    Activation profiles of human kallikrein-related peptidases by proteases of the thrombostasis axis
    Protein Sci (2008) 17, 1998-2007. PubMed  Europe PubMed DOI  PMC  EPMC
    14. 2007
  14. Fernando,S.C., Najar,F.Z., Guo,X., Zhou,L., Fu,Y., Geisert,R.D., Roe,B.A. and DeSilva,U.
    Porcine kallikrein gene family: genomic structure, mapping, and differential expression analysis
    Genomics (2007) 89, 429-438. PubMed  Europe PubMed DOI
  15. McIntosh,M.W., Liu,Y., Drescher,C., Urban,N. and Diamandis,E.P.
    Validation and characterization of human kallikrein 11 as a serum marker for diagnosis of ovarian carcinoma
    Clin Cancer Res (2007) 13, 4422-4428. PubMed  Europe PubMed DOI
  16. Sano,A., Sangai,T., Maeda,H., Nakamura,M., Hasebe,T. and Ochiai,A.
    Kallikrein 11 expressed in human breast cancer cells releases insulin-like growth factor through degradation of IGFBP-3
    Int J Oncol (2007) 30, 1493-1498. PubMed  Europe PubMed
  17. Yoon,H., Laxmikanthan,G., Lee,J., Blaber,S.I., Rodriguez,A., Kogot,J.M., Scarisbrick,I.A. and Blaber,M.
    Activation profiles and regulatory cascades of the human kallikrein-related peptidases
    J Biol Chem (2007) 282, 31852-31864. PubMed  Europe PubMed DOI  V
    18. 2006
  18. [YEAR:1-6-2006]Debela,M., Magdolen,V., Schechter,N., Valachova,M., Lottspeich,F., Craik,C.S., Choe,Y., Bode,W. and Goettig,P.
    Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences
    J Biol Chem (1-6-2006) 281, 25678-25688. PubMed  Europe PubMed DOI  P
  19. [YEAR:1-2-2006]Luo,L.Y., Shan,S.J., Elliott,M.B., Soosaipillai,A. and Diamandis,E.P.
    Purification and characterization of human kallikrein 11, a candidate prostate and ovarian cancer biomarker, from seminal plasma
    Clin Cancer Res (1-2-2006) 12, 742-750. PubMed  Europe PubMed DOI
  20. Luo,L.Y. and Jiang,W.
    Inhibition profiles of human tissue kallikreins by serine protease inhibitors
    Biol Chem (2006) 387, 813-816. PubMed  Europe PubMed DOI
  21. Mitsui,S., Nakamura,T., Okui,A., Kominami,K., Uemura,H. and Yamaguchi,N.
    Multiple promoters regulate tissue-specific alternative splicing of the human kallikrein gene, KLK11/hippostasin
    FEBS J (2006) 273, 3678-3686. PubMed  Europe PubMed DOI  R
    22. 2005
  22. [YEAR:25-5-2005]Kurlender,L., Borgono,C., Michael,I.P., Obiezu,C., Elliott,M.B., Yousef,G.M. and Diamandis,E.P.
    A survey of alternative transcripts of human tissue kallikrein genes
    Biochim Biophys Acta (25-5-2005) 1755, 1-14. PubMed  Europe PubMed DOI  R
  23. [YEAR:11-5-2005]Stavropoulou,P., Gregorakis,A.K., Plebani,M. and Scorilas,A.
    Expression analysis and prognostic significance of human kallikrein 11 in prostate cancer
    Clin Chim Acta (11-5-2005) 357, 190-195. PubMed  Europe PubMed DOI
    24. 2004
  24. Clements,J.A., Hooper,J.D., Odorico,D.M. and Dong,Y.
    The tissue kallikrein gene cluster
    [ISSN:0-12-079610-4] (2004) 2, 1569-1577.  V
  25. Diamandis,E.P., Borgono,C.A., Scorilas,A., Harbeck,N., Dorn,J. and Schmitt,M.
    Human kallikrein 11: an indicator of favorable prognosis in ovarian cancer patients
    Clin Biochem (2004) 37, 823-829. PubMed  Europe PubMed DOI
  26. [YEAR:15-4-2004]Shigemasa,K., Gu,L., Tanimoto,H., O'Brien,T.J. and Ohama,K.
    Human kallikrein gene 11 (KLK11) mRNA overexpression is associated with poor prognosis in patients with epithelial ovarian cancer
    Clin Cancer Res (15-4-2004) 10, 2766-2770. PubMed  Europe PubMed DOI
  27. Yamaguchi,N.
    Human kallikrein 11 or hippostasin
    [ISSN:0-12-079610-4] (2004) 2, 1595-1597.  V
    28. 2003
  28. [YEAR:10-9-2003]Borgono,C.A., Fracchioli,S., Yousef,G.M., Rigault de la Longrais,I.A., Luo,L.Y., Soosaipillai,A., Puopolo,M., Grass,L., Scorilas,A., Diamandis,E.P. and Katsaros,D.
    Favorable prognostic value of tissue human kallikrein 11 (hK11) in patients with ovarian carcinoma
    Int J Cancer (10-9-2003) 106, 605-610. PubMed  Europe PubMed DOI
  29. [YEAR:1-3-2003]Nakamura,T., Mitsui,S., Okui,A., Miki,T. and Yamaguchi,N.
    Molecular cloning and expression of a variant form of hippostasin/KLK11 in prostate
    Prostate (1-3-2003) 54, 299-305. PubMed  Europe PubMed DOI  R
  30. Nakamura,T., Stephan,C., Scorilas,A., Yousef,G.M., Jung,K. and Diamandis,E.P.
    Quantitative analysis of hippostasin/KLK11 gene expression in cancerous and noncancerous prostatic tissues
    Urology (2003) 61, 1042-1046. PubMed  Europe PubMed DOI  R
  31. [YEAR:1-5-2003]Yousef,G.M., Polymeris,M.E., Yacoub,G.M., Scorilas,A., Soosaipillai,A., Popalis,C., Fracchioli,S., Katsaros,D. and Diamandis,E.P.
    Parallel overexpression of seven kallikrein genes in ovarian cancer
    Cancer Res (1-5-2003) 63, 2223-2227. PubMed  Europe PubMed
    32. 2002
  32. [YEAR:1-1-2002]Diamandis,E.P., Okui,A., Mitsui,S., Luo,L.Y., Soosaipillai,A., Grass,L., Nakamura,T., Howarth,D.J. and Yamaguchi,N.
    Human kallikrein 11: a new biomarker of prostate and ovarian carcinoma
    Cancer Res (1-1-2002) 62, 295-300. PubMed  Europe PubMed  E
    33. 2001
  33. Clements,J., Hooper,J., Dong,Y. and Harvey,T.
    The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions
    Biol Chem (2001) 382, 5-14. PubMed  Europe PubMed DOI  V
  34. [YEAR:15-9-2001]Nakamura,T., Mitsui,S., Okui,A., Kominami,K., Nomoto,T., Ukimura,O., Kawauchi,A., Miki,T. and Yamaguchi,N.
    Alternative splicing isoforms of hippostasin (PRSS20/KLK11) in prostate cancer cell lines
    Prostate (15-9-2001) 49, 72-78. PubMed  Europe PubMed DOI  R
    35. 2000
  35. [YEAR:15-11-2000]Mitsui,S., Okui,A., Kominami,K., Uemura,H. and Yamaguchi,N.
    cDNA cloning and tissue-specific splicing variants of mouse hippostasin/TLSP (PRSS20)
    Biochim Biophys Acta (15-11-2000) 1494, 206-210. PubMed  Europe PubMed
  36. [YEAR:27-5-2000]Mitsui,S., Yamada,T., Okui,A., Kominami,K., Uemura,H. and Yamaguchi,N.
    A novel isoform of a kallikrein-like protease, TLSP/hippostasin, (PRSS20), is expressed in the human brain and prostate
    Biochem Biophys Res Commun (27-5-2000) 272, 205-211. PubMed  Europe PubMed DOI  R
  37. [YEAR:1-1-2000]Yousef,G.M., Scorilas,A. and Diamandis,E.P.
    Genomic organization, mapping, tissue expression, and hormonal regulation of trypsin-like serine protease (TLSP PRSS20), a new member of the human kallikrein gene family
    Genomics (1-1-2000) 63, 88-96. PubMed  Europe PubMed DOI
    38. 1998
  38. Yoshida,S., Taniguchi,M., Suemoto,T., Oka,T., He,X. and Shiosaka,S.
    cDNA cloning and expression of a novel serine protease, TLSP
    Biochim Biophys Acta (1998) 1399, 225-228. PubMed  Europe PubMed DOI

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2026 EBI
Terms of use