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Literature for peptidase S01.244: kallikrein-related peptidase 8

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, R Splicing. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Bulliard,M., Pinjusic,K., Iacobucci,L., Schmuziger,C., Fournier,N. and Constam,D.B.
    Kallikrein-8 mediates furin-independent Activin-A precursor processing to stimulate tumor growth in melanoma
    Nat Commun (2025) 16, 2354-2354. PubMed  Europe PubMed DOI  PMC  EPMC  K
  2. Shen,X., Qiao,W., Yan,W., Xie,H., Zhang,C., Sun,Y., Luo,Q. and Xu,Q.
    Keratinocyte-specific H4K12 lactylation drives a non-canonical IL-17-dependent signaling in psoriasis progression in mice
    Nat Commun (2025) 16, 8639-8639. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2024
  3. Barman,B. and Thakur,M.K.
    Neuropsin promotes hippocampal synaptogenesis by regulating the expression and cleavage of L1CAM
    J Cell Sci (2024) 137 PubMed  Europe PubMed DOI  K
  4. Boumali,R., Urli,L., Naim,M., Soualmia,F., Kinugawa,K., Petropoulos,I. and El Amri,C.
    Kallikrein-related peptidase's significance in Alzheimer's disease pathogenesis: A comprehensive survey
    Biochimie (2024) 226, 77-90. PubMed  Europe PubMed DOI
    5. 2023
  5. Stuardo-Parada,A., Lopez-Munoz,R., Villarroel-Espindola,F., Figueroa,C.D. and Ehrenfeld,P.
    Minireview: functional roles of tissue kallikrein, kinins, and kallikrein-related peptidases in lung cancer
    Med Oncol (2023) 40, 224-224. PubMed  Europe PubMed DOI  V
  6. Xu,D.H., Du,J.K., Liu,S.Y., Zhang,H., Yang,L., Zhu,X.Y. and Liu,Y.J.
    Upregulation of KLK8 contributes to CUMS-induced hippocampal neuronal apoptosis by cleaving NCAM1
    Cell Death Dis (2023) 14, 278-278. PubMed  Europe PubMed DOI  PMC  EPMC
    7. 2022
  7. Wagdi,A., Malan,D., Sathyanarayanan,U., Beauchamp,J.S., Vogt,M., Zipf,D., Beiert,T., Mansuroglu,B., Dusend,V., Meininghaus,M., Schneider,L., Kalthof,B., Wiegert,J.S., Konig,G.M., Kostenis,E., Patejdl,R., Sasse,P. and Bruegmann,T.
    Selective optogenetic control of Gq signaling using human Neuropsin
    Nat Commun (2022) 13, 1765-1765. PubMed  Europe PubMed DOI  PMC  EPMC
    8. 2021
  8. Hua,Q., Sun,Z., Liu,Y., Shen,X., Zhao,W., Zhu,X. and Xu,P.
    KLK8 promotes the proliferation and metastasis of colorectal cancer via the activation of EMT associated with PAR1
    Cell Death Dis (2021) 12, 860-860. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Jiang,X., Pardue,M.T., Mori,K., Ikeda,S.I., Torii,H., D'Souza,S., Lang,R.A., Kurihara,T. and Tsubota,K.
    Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice
    Proc Natl Acad Sci U S A (2021) 118 PubMed  Europe PubMed DOI  PMC  EPMC
  10. Zani,M.B., Sant'Ana,A.M., Tognato,R.C., Chagas,J.R. and Puzer,L.
    Human Tissue Kallikreins-Related Peptidases Are Targets for the Treatment of Skin Desquamation Diseases
    Front Med (Lausanne) (2021) 8, 777619-777619. PubMed  Europe PubMed DOI  PMC  EPMC  V
    11. 2020
  11. Bukowski,L., Chernomorchenko,A.M.F., Starnawska,A., Mors,O., Staunstrup,N.H., Borglum,A.D. and Qvist,P.
    Neuropsin in mental health
    J Physiol Sci (2020) 70, 26-26. PubMed  Europe PubMed DOI
  12. Lim,S.C., Kee,K.H., Lee,M.J., Hong,R. and Han,S.I.
    Extracellular acidity induced expression of kallikrein related peptidases 7 and 8 is involved in increased invasiveness of gastric cancer cells
    Oncol Rep (2020) 43, 1705-1713. PubMed  Europe PubMed DOI
  13. Mella,C., Figueroa,C.D., Otth,C. and Ehrenfeld,P.
    Involvement of Kallikrein-Related Peptidases in Nervous System Disorders
    Front Cell Neurosci (2020) 14, 166-166. PubMed  Europe PubMed DOI  PMC  EPMC  V
  14. Munster,Y., Keyvani,K. and Herring,A.
    Inhibition of excessive kallikrein-8 improves neuroplasticity in Alzheimer's disease mouse model
    Exp Neurol (2020) 324, 113115-113115. PubMed  Europe PubMed DOI
  15. Teuber-Hanselmann,S., Rekowski,J., Vogelgsang,J., von Arnim,C., Reetz,K., Stang,A., Jockel,K.H., Wiltfang,J., Esselmann,H., Otto,M., Tumani,H., Herring,A. and Keyvani,K.
    CSF and blood kallikrein-8: a promising early biomarker for Alzheimer's disease
    J Neurol Neurosurg Psychiatry (2020) 91, 40-48. PubMed  Europe PubMed DOI
    16. 2019
  16. Huang,M., Du,J., Wang,Y., Ma,S., Hu,T., Shang,J., Yu,Q., Zhu,X., Zhang,G. and Cong,B.
    Tissue kallikrein-related peptidase8 protects rat heart against acute ischemia reperfusion injury
    Int J Biol Macromol (2019) 140, 1126-1133. PubMed  Europe PubMed DOI
  17. Nakazawa,H., Suzuki,Y., Ishikawa,Y., Bando,Y., Yoshida,S. and Shiosaka,S.
    Impaired social discrimination behavior despite normal social approach by kallikrein-related peptidase 8 knockout mouse
    Neurobiol Learn Mem (2019) 162, 47-58. PubMed  Europe PubMed DOI
  18. Nakazawa,H., Suzuki,Y., Ishikawa,Y., Bando,Y., Yoshida,S. and Shiosaka,S.
    Dataset on the effect of knockout of KLK8 in social memory
    Data Brief (2019) 26, 104458-104458. PubMed  Europe PubMed DOI  PMC  EPMC
    19. 2018
  19. Debela,M., Magdolen,V., Skala,W., Elsasser,B., Schneider,E.L., Craik,C.S., Biniossek,M.L., Schilling,O., Bode,W., Brandstetter,H. and Goettig,P.
    Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin
    Sci Rep (2018) 8, 10705-10705. PubMed  Europe PubMed DOI  PMC  EPMC  P
  20. Grunberg,M., Quandt,D., Cynis,H., Demuth,H.U., Kindermann,A., Magdolen,V., Forssmann,W.G., Seliger,B. and Magert,H.J.
    Kallikrein-related peptidases are activators of the CC chemokine CCL14
    Eur J Immunol (2018) 48, 1592-1594. PubMed  Europe PubMed DOI
  21. Konar,A., Kumar,A., Maloney,B., Lahiri,D.K. and Thakur,M.K.
    A serine protease KLK8 emerges as a regulator of regulators in memory: microtubule protein dependent neuronal morphology and PKA-CREB signaling
    Sci Rep (2018) 8, 9928-9928. PubMed  Europe PubMed DOI  PMC  EPMC
    22. 2017
  22. Adamopoulos,P.G., Kontos,C.K. and Scorilas,A.
    Molecular cloning of novel transcripts of human kallikrein-related peptidases 5, 6, 7, 8 and 9 (KLK5 - KLK9), using Next-generation sequencing
    Sci Rep (2017) 7, 17299-17299. PubMed  Europe PubMed DOI  PMC  EPMC  M
  23. Hecker,N., Sharma,V. and Hiller,M.
    Transition to an aquatic habitat permitted the repeated loss of the pleiotropic KLK8 gene in mammals
    Genome Biol Evol (2017) 9, 3179-3188. PubMed  Europe PubMed DOI
  24. Kawata,M., Morikawa,S., Shiosaka,S. and Tamura,H.
    Ablation of neuropsin-neuregulin 1 signaling imbalances ErbB4 inhibitory networks and disrupts hippocampal gamma oscillation
    Transl Psychiatry (2017) 7, e1052-e1052. PubMed  Europe PubMed DOI
  25. Lahiri,D.K., Konar,A., Thakur,M.K. and Maloney,B.
    A cardinal sin when researching neuropsin/KLK8: Thou shalt validate antibodies
    Alzheimers Dement (2017) 13, 1068-1069. PubMed  Europe PubMed DOI
    26. 2016
  26. Chang,S., Bok,P., Sun,C.P., Edwards,A. and Huang,G.J.
    Neuropsin inactivation has protective effects against depressive-like behaviours and memory impairment induced by chronic stress
    PLoS Genet (2016) 12, e1006356-e1006356. PubMed  Europe PubMed DOI  K
  27. Herring,A., Munster,Y., Akkaya,T., Moghaddam,S., Deinsberger,K., Meyer,J., Zahel,J., Sanchez-Mendoza,E., Wang,Y., Hermann,D.M., Arzberger,T., Teuber-Hanselmann,S. and Keyvani,K.
    Kallikrein-8 inhibition attenuates Alzheimer's disease pathology in mice
    Alzheimers Dement (2016) 12, 1273-1287. PubMed  Europe PubMed DOI
  28. Karakosta,T.D., Soosaipillai,A., Diamandis,E.P., Batruch,I. and Drabovich,A.P.
    Quantification of human kallikrein-related peptidases in biological fluids by multiplatform targeted mass spectrometry assays
    Mol Cell Proteomics (2016) 15, 2863-2876. PubMed  Europe PubMed DOI  A
    29. 2015
  29. Cerqueira,C., Samperio Ventayol,P., Vogeley,C. and Schelhaas,M.
    Kallikrein-8 proteolytically processes human papillomaviruses in the extracellular space to facilitate entry into host cells
    J Virol (2015) 89, 7038-7052. PubMed  Europe PubMed DOI
    30. 2014
  30. Azam,S.S. and Raza,S.
    Structure modeling and hybrid virtual screening study of Alzheimer's associated protease kallikrein 8 for the identification of novel inhibitors
    Med Chem Res (2014) 23, 3516-3527. DOI  I
  31. Sonderegger,P. and Matsumoto-Miyai,K.
    Activity-controlled proteolytic cleavage at the synapse
    Trends Neurosci (2014) 37, 413-423. PubMed  Europe PubMed DOI
  32. Suzuki,H., Kanagawa,D., Nakazawa,H., Tawara-Hirata,Y., Kogure,Y., Shimizu-Okabe,C., Takayama,C., Ishikawa,Y. and Shiosaka,S.
    Role of neuropsin in parvalbumin immunoreactivity changes in hippocampal basket terminals of mice reared in various environments
    Front Cell Neurosci (2014) 8, 420-420. PubMed  Europe PubMed DOI  PMC  EPMC
  33. Tawara-Hirata,Y.
    [Neuropsin signaling as a novel therapeutic target of schizophrenia]
    Nihon Yakurigaku Zasshi (2014) 143, 153-155. PubMed  Europe PubMed DOI
    34. 2013
  34. Lundwall,A.
    Old genes and new genes: The evolution of the kallikrein locus
    Thromb Haemost (2013) 110, 469-475. PubMed  Europe PubMed DOI  V
    35. 2012
  35. Clements,J.A., Hooper,J.D. and Dong,Y.
    The human tissue kallikrein and kallikrein-related peptidase family
    [ISSN:978-0-12-407742-3] (2012) 3, 2747-2756. DOI
  36. Eissa,A. and Diamandis,E.P.
    Kallikrein-related peptidase 8
    [ISSN:978-0-12-407742-3] (2012) 3, 2792-2798. DOI
  37. Tamura,H., Kawata,M., Hamaguchi,S., Ishikawa,Y. and Shiosaka,S.
    Processing of neuregulin-1 by neuropsin regulates GABAergic neuron to control neural plasticity of the mouse hippocampus
    J Neurosci (2012) 32, 12657-12672. PubMed  Europe PubMed DOI
    38. 2011
  38. Attwood,B.K., Bourgognon,J.M., Patel,S., Mucha,M., Schiavon,E., Skrzypiec,A.E., Young,K.W., Shiosaka,S., Korostynski,M., Piechota,M., Przewlocki,R. and Pawlak,R.
    Neuropsin cleaves EphB2 in the amygdala to control anxiety
    Nature (2011) 473, 372-375. PubMed  Europe PubMed DOI  K
  39. Eissa,A., Amodeo,V., Smith,C.R. and Diamandis,E.P.
    Kallikrein-related peptidase-8 (KLK8) is an active serine protease in human epidermis and sweat and is involved in a skin barrier proteolytic cascade
    J Biol Chem (2011) 286, 687-706. PubMed  Europe PubMed DOI
  40. Ishikawa,Y., Tamura,H. and Shiosaka,S.
    Diversity of neuropsin (KLK8)-dependent synaptic associativity in the hippocampal pyramidal neuron
    J Physiol (2011) 589, 3559-3573. PubMed  Europe PubMed DOI
  41. Shiosaka,S. and Ishikawa,Y.
    Neuropsin - a possible modulator of synaptic plasticity
    J Chem Neuroanat (2011) 42, 24-29. PubMed  Europe PubMed DOI  K
    42. 2010
  42. Angelopoulou,K. and Karagiannis,G.S.
    Structural characterization and expression of five novel canine kallikrein-related peptidases in mammary cancer
    Mamm Genome (2010) 21, 516-524. PubMed  Europe PubMed DOI
  43. Shingaki,K., Matsuzaki,S., Taniguchi,M., Kubo,T., Fujiwara,T., Kanazawa,S., Yamamoto,A., Tamura,H., Maeda,T., Ooi,K., Matsumoto,K., Shiosaka,S. and Tohyama,M.
    Molecular mechanism of kallikrein-related peptidase 8/neuropsin-induced hyperkeratosis in inflamed skin
    Br J Dermatol (2010) 163, 466-475. PubMed  Europe PubMed DOI  K
  44. Yoshida,S.
    Klk8, a multifunctional protease in the brain and skin: analysis of knockout mice
    Biol Chem (2010) 391, 375-380. PubMed  Europe PubMed DOI  K
    45. 2009
  45. Kountourakis,P., Psyrri,A., Scorilas,A., Markakis,S., Kowalski,D., Camp,R.L., Diamandis,E.P. and Dimopoulos,M.A.
    Expression and prognostic significance of kallikrein-related peptidase 8 protein levels in advanced ovarian cancer by using automated quantitative analysis
    Thromb Haemost (2009) 101, 541-546. PubMed  Europe PubMed DOI
    46. 2008
  46. Clements,J.A.
    Reflections on the tissue kallikrein and kallikrein-related peptidase family - from mice to men - what have we learnt in the last two decades?
    Biol Chem (2008) 389, 1447-1454. PubMed  Europe PubMed DOI  V
  47. Horii,Y., Yamasaki,N., Miyakawa,T. and Shiosaka,S.
    Increased anxiety-like behavior in neuropsin (kallikrein-related peptidase 8) gene-deficient mice
    Behav Neurosci (2008) 122, 498-504. PubMed  Europe PubMed DOI  K
  48. Ishikawa,Y., Horii,Y., Tamura,H. and Shiosaka,S.
    Neuropsin (KLK8)-dependent and -independent synaptic tagging in the Schaffer-collateral pathway of mouse hippocampus
    J Neurosci (2008) 28, 843-849. PubMed  Europe PubMed DOI
  49. Izumi,A., Iijima,Y., Noguchi,H., Numakawa,T., Okada,T., Hori,H., Kato,T., Tatsumi,M., Kosuga,A., Kamijima,K., Asada,T., Arima,K., Saitoh,O., Shiosaka,S. and Kunugi,H.
    Genetic variations of human neuropsin gene and psychiatric disorders: polymorphism screening and possible association with bipolar disorder and cognitive functions
    Neuropsychopharmacology (2008) 33, 3237-3245. PubMed  Europe PubMed DOI
  50. Wang,Y., Luo,W. and Reiser,G.
    Trypsin and trypsin-like proteases in the brain: proteolysis and cellular functions
    Cell Mol Life Sci (2008) 65, 237-252. PubMed  Europe PubMed DOI  V
    51. 2007
  51. Fernando,S.C., Najar,F.Z., Guo,X., Zhou,L., Fu,Y., Geisert,R.D., Roe,B.A. and DeSilva,U.
    Porcine kallikrein gene family: genomic structure, mapping, and differential expression analysis
    Genomics (2007) 89, 429-438. PubMed  Europe PubMed DOI
  52. Kishibe,M., Bando,Y., Terayama,R., Namikawa,K., Takahashi,H., Hashimoto,Y., Ishida-Yamamoto,A., Jiang,Y.P., Mitrovic,B., Perez,D., Iizuka,H. and Yoshida,S.
    Kallikrein 8 is involved in skin desquamation in cooperation with other kallikreins
    J Biol Chem (2007) 282, 5834-5841. PubMed  Europe PubMed DOI
  53. Lu,Z.X., Peng,J. and Su,B.
    A human-specific mutation leads to the origin of a novel splice form of neuropsin (KLK8), a gene involved in learning and memory
    Hum Mutat (2007) 28, 978-984. PubMed  Europe PubMed DOI  M
  54. Scott,F.L., Sun,J., Whisstock,J.C., Kato,K. and Bird,P.I.
    SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes
    J Biochem (2007) 142, 435-442. PubMed  Europe PubMed DOI
  55. Terayama,R., Bando,Y., Murakami,K., Kato,K., Kishibe,M. and Yoshida,S.
    Neuropsin promotes oligodendrocyte death, demyelination and axonal degeneration after spinal cord injury
    Neuroscience (2007) 148, 175-187. PubMed  Europe PubMed DOI  K
  56. Weinsheimer,S., Goddard,K.A., Parrado,A.R., Lu,Q., Sinha,M., Lebedeva,E.R., Ronkainen,A., Niemela,M., Khusnutdinova,E.K., Khusainova,R.I., Helin,K., Jaaskelainen,J.E., Sakovich,V.P., Land,S., Kuivaniemi,H. and Tromp,G.
    Association of kallikrein gene polymorphisms with intracranial aneurysms
    Stroke (2007) 38, 2670-2676. PubMed  Europe PubMed DOI  M
  57. Yoon,H., Laxmikanthan,G., Lee,J., Blaber,S.I., Rodriguez,A., Kogot,J.M., Scarisbrick,I.A. and Blaber,M.
    Activation profiles and regulatory cascades of the human kallikrein-related peptidases
    J Biol Chem (2007) 282, 31852-31864. PubMed  Europe PubMed DOI  V
    58. 2006
  58. Kishi,T., Cloutier,S.M., Kundig,C., Deperthes,D. and Diamandis,E.P.
    Activation and enzymatic characterization of recombinant human kallikrein 8
    Biol Chem (2006) 387, 723-731. PubMed  Europe PubMed DOI
  59. Luo,L.Y. and Jiang,W.
    Inhibition profiles of human tissue kallikreins by serine protease inhibitors
    Biol Chem (2006) 387, 813-816. PubMed  Europe PubMed DOI
  60. [YEAR:1-4-2006]Nakamura,Y., Tamura,H., Horinouchi,K. and Shiosaka,S.
    Role of neuropsin in formation and maturation of Schaffer-collateral L1cam-immunoreactive synaptic boutons
    J Cell Sci (1-4-2006) 119, 1341-1349. PubMed  Europe PubMed DOI
  61. [YEAR:15-12-2006]Sher,Y.P., Chou,C.C., Chou,R.H., Wu,H.M., Wayne Chang,W.S., Chen,C.H., Yang,P.C., Wu,C.W., Yu,C.L. and Peck,K.
    Human kallikrein 8 protease confers a favorable clinical outcome in non-small cell lung cancer by suppressing tumor cell invasiveness
    Cancer Res (15-12-2006) 66, 11763-11770. PubMed  Europe PubMed DOI
  62. [YEAR:24-11-2006]Tamura,H., Ishikawa,Y., Hino,N., Maeda,M., Yoshida,S., Kaku,S. and Shiosaka,S.
    Neuropsin is essential for early processes of memory acquisition and Schaffer collateral long-term potentiation in adult mouse hippocampus in vivo
    J Physiol (24-11-2006) 570, 541-551. PubMed  Europe PubMed DOI  PMC  EPMC
    63. 2005
  63. [YEAR:25-5-2005]Kurlender,L., Borgono,C., Michael,I.P., Obiezu,C., Elliott,M.B., Yousef,G.M. and Diamandis,E.P.
    A survey of alternative transcripts of human tissue kallikrein genes
    Biochim Biophys Acta (25-5-2005) 1755, 1-14. PubMed  Europe PubMed DOI  R
  64. [YEAR:19-12-2005]Rajapakse,S., Ogiwara,K., Takano,N., Moriyama,A. and Takahashi,T.
    Biochemical characterization of human kallikrein 8 and its possible involvement in the degradation of extracellular matrix proteins
    FEBS Lett (19-12-2005) 579, 6879-6884. PubMed  Europe PubMed DOI
  65. [YEAR:26-5-2005]Terayama,R., Bando,Y., Yamada,M. and Yoshida,S.
    Involvement of neuropsin in the pathogenesis of experimental autoimmune encephalomyelitis
    Glia (26-5-2005) 52, 108-118. PubMed  Europe PubMed DOI
    66. 2004
  66. Cane,S., Bignotti,E., Bellone,S., Palmieri,M., De las Casas,L., Roman,J.J., Pecorelli,S., Cannon,M.J., O'Brien,T. and Santin,A.D.
    The novel serine protease tumor-associated differentially expressed gene-14 (KLK8/Neuropsin/Ovasin) is highly overexpressed in cervical cancer
    Am J Obstet Gynecol (2004) 190, 60-66. PubMed  Europe PubMed DOI
  67. Clements,J.A., Hooper,J.D., Odorico,D.M. and Dong,Y.
    The tissue kallikrein gene cluster
    [ISSN:0-12-079610-4] (2004) 2, 1569-1577.  V
  68. Kishi,T. and Diamandis,E.P.
    Neuropsin, human tissue kallikrein 8
    [ISSN:0-12-079610-4] (2004) 2, 1591-1593.  V
  69. [YEAR:28-7-2004]Li,Y., Qian,Y.P., Yu,X.J., Wang,Y.Q., Dong,D.G., Sun,W., Ma,R.M. and Su,B.
    Recent origin of a hominoid-specific splice form of neuropsin, a gene involved in learning and memory
    Mol Biol Evol (28-7-2004) 21, 2111-2115. PubMed  Europe PubMed DOI  R
  70. Shigemasa,K., Tian,X., Gu,L., Tanimoto,H., Underwood,L.J., O'Brien,T.J. and Ohama,K.
    Human kallikrein 8 (hK8/TADG-14) expression is associated with an early clinical stage and favorable prognosis in ovarian cancer
    Oncol Rep (2004) 11, 1153-1159. PubMed  Europe PubMed
  71. Terayama,R., Bando,Y., Takahashi,T. and Yoshida,S.
    Differential expression of neuropsin and protease M/neurosin in oligodendrocytes after injury to the spinal cord
    Glia (2004) 48, 91-101. PubMed  Europe PubMed DOI
    72. 2003
  72. Kirihara,T., Matsumoto-Miyai,K., Nakamura,Y., Sadayama,T., Yoshida,S. and Shiosaka,S.
    Prolonged recovery of ultraviolet B-irradiated skin in neuropsin (KLK8)-deficient mice
    Br J Dermatol (2003) 149, 700-706. PubMed  Europe PubMed DOI  K
  73. [YEAR:1-6-2003]Kishi,T., Grass,L., Soosaipillai,A., Scorilas,A., Harbeck,N., Schmalfeldt,B., Dorn,J., Mysliwiec,M., Schmitt,M. and Diamandis,E.P.
    Human kallikrein 8, a novel biomarker for ovarian carcinoma
    Cancer Res (1-6-2003) 63, 2771-2774. PubMed  Europe PubMed
  74. Kishi,T., Grass,L., Soosaipillai,A., Shimizu-Okabe,C. and Diamandis,E.P.
    Human kallikrein 8: immunoassay development and identification in tissue extracts and biological fluids
    Clin Chem (2003) 49, 87-96. PubMed  Europe PubMed DOI  A
  75. [YEAR:27-8-2003]Matsumoto-Miyai,K., Ninomiya,A., Yamasaki,H., Tamura,H., Nakamura,Y. and Shiosaka,S.
    NMDA-dependent proteolysis of presynaptic adhesion molecule L1 in the hippocampus by neuropsin
    J Neurosci (27-8-2003) 23, 7727-7736. PubMed  Europe PubMed
  76. [YEAR:28-3-2003]Wong,G.W., Yang,Y., Yasuda,S., Li,L. and Stevens,R.L.
    Mouse mast cells express the tryptic protease neuropsin/Prss19
    Biochem Biophys Res Commun (28-3-2003) 303, 320-325. PubMed  Europe PubMed DOI
  77. [YEAR:1-5-2003]Yousef,G.M., Polymeris,M.E., Yacoub,G.M., Scorilas,A., Soosaipillai,A., Popalis,C., Fracchioli,S., Katsaros,D. and Diamandis,E.P.
    Parallel overexpression of seven kallikrein genes in ovarian cancer
    Cancer Res (1-5-2003) 63, 2223-2227. PubMed  Europe PubMed
    78. 2002
  78. [YEAR:30-9-2002]Katsu,Y., Takasu,E. and Iguchi,T.
    Estrogen-independent expression of neuropsin, a serine protease in the vagina of mice exposed neonatally to diethylstilbestrol
    Mol Cell Endocrinol (30-9-2002) 195, 99-107. PubMed  Europe PubMed DOI
  79. Kuwae,K., Matsumoto-Miyai,K., Yoshida,S., Sadayama,T., Yoshikawa,K., Hosokawa,K. and Shiosaka,S.
    Epidermal expression of serine protease, neuropsin (KLK8) in normal and pathological skin samples
    Mol Pathol (2002) 55, 235-241. PubMed  Europe PubMed DOI  PMC  EPMC
  80. Matsumoto-Miyai,K., Kitagawa,R., Ninomiya,A., Momota,Y., Yoshida,S. and Shiosaka,S.
    Decidualization induces the expression and activation of an extracellular protease neuropsin in mouse uterus
    Biol Reprod (2002) 67, 1414-1418. PubMed  Europe PubMed DOI
  81. [YEAR:26-4-2002]Oka,T., Hakoshima,T., Itakura,M., Yamamori,S., Takahashi,M., Hashimoto,Y., Shiosaka,S. and Kato,K.
    Role of loop structures of neuropsin in the activity of serine protease and regulated secretion
    J Biol Chem (26-4-2002) 277, 14724-14730. PubMed  Europe PubMed DOI
  82. [YEAR:22-3-2002]Oka,T., Akisada,M., Okabe,A., Sakurai,K., Shiosaka,S. and Kato,K.
    Extracellular serine protease neuropsin (KLK8) modulates neurite outgrowth and fasciculation of mouse hippocampal neurons in culture
    Neurosci Lett (22-3-2002) 321, 141-144. PubMed  Europe PubMed DOI
    83. 2001
  83. Clements,J., Hooper,J., Dong,Y. and Harvey,T.
    The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions
    Biol Chem (2001) 382, 5-14. PubMed  Europe PubMed DOI  V
  84. [YEAR:15-9-2001]Davies,B., Kearns,I.R., Ure,J., Davies,C.H. and Lathe,R.
    Loss of hippocampal serine protease BSP1/neuropsin predisposes to global seizure activity
    J Neurosci (15-9-2001) 21, 6993-7000. PubMed  Europe PubMed
  85. He,X.P., Shiosaka,S. and Yoshida,S.
    Expression of neuropsin in oligodendrocytes after injury to the CNS
    Neurosci Res (2001) 39, 455-462. PubMed  Europe PubMed DOI
  86. Hirata,A., Yoshida,S., Inoue,N., Matsumoto-Miyai,K., Ninomiya,A., Taniguchi,M., Matsuyama,T., Kato,K., Iizasa,H., Kataoka,Y., Yoshida,N. and Shiosaka,S.
    Abnormalities of synapses and neurons in the hippocampus of neuropsin-deficient mice
    Mol Cell Neurosci (2001) 17, 600-610. PubMed  Europe PubMed DOI  K
  87. [YEAR:4-5-2001]Kato,K., Kishi,T., Kamachi,T., Akisada,M., Oka,T., Midorikawa,R., Takio,K., Dohmae,N., Bird,P.I., Sun,J., Scott,F., Miyake,Y., Yamamoto,K., Machida,A., Tanaka,T., Matsumoto,K., Shibata,M. and Shiosaka,S.
    Serine proteinase inhibitor 3 and murinoglobulin I are potent inhibitors of neuropsin in adult mouse brain
    J Biol Chem (4-5-2001) 276, 14562-14571. PubMed  Europe PubMed DOI
  88. Magklara,A., Scorilas,A., Katsaros,D., Massobrio,M., Yousef,G.M., Fracchioli,S., Danese,S. and Diamandis,E.P.
    The human KLK8 (neuropsin/ovasin) gene: identification of two novel splice variants and its prognostic value in ovarian cancer
    Clin Cancer Res (2001) 7, 806-811. PubMed  Europe PubMed  R
  89. Tani,N., Matsumoto,K., Ota,I., Yoshida,S., Takada,Y., Shiosaka,S. and Matsuura,N.
    Effects of fibronectin cleaved by neuropsin on cell adhesion and migration
    Neurosci Res (2001) 39, 247-251. PubMed  Europe PubMed DOI
    90. 2000
  90. Komai,S., Matsuyama,T., Matsumoto,K., Kato,K., Kobayashi,M., Imamura,K., Yoshida,S., Ugawa,S. and Shiosaka,S.
    Neuropsin regulates an early phase of Schaffer-collateral long-term potentiation in the murine hippocampus
    Eur J Neurosci (2000) 12, 1479-1486. PubMed  Europe PubMed DOI
  91. Yoshida,S., Hirata,A., Inoue,N. and Shiosaka,S.
    Assignment of the neuropsin gene (Prss 19) to mouse chromosome band 7B4 by in situ hybridization
    Cytogenet Cell Genet (2000) 88, 97-98. PubMed  Europe PubMed
    92. 1999
  92. [YEAR:12-2-1999]Kishi,T., Kato,M., Shimizu,T., Kato,K., Matsumoto,K., Yoshida,S., Shiosaka,S. and Hakoshima,T.
    Crystal structure of neuropsin, a hippocampal protease involved in kindling epileptogenesis
    J Biol Chem (12-2-1999) 274, 4220-4224. PubMed  Europe PubMed DOI  S
  93. Mitsui,S., Tsuruoka,N., Yamashiro,K., Nakazato,H. and Yamaguchi,N.
    A novel form of human neuropsin, a brain-related serine protease, is generated by alternative splicing and is expressed preferentially in human adult brain
    Eur J Biochem (1999) 260, 627-634. PubMed  Europe PubMed DOI  R
  94. Takahashi,N., Tsukamoto,Y., Shiosaka,S., Kishi,T., Hakoshima,T., Arata,Y., Yamaguchi,Y., Kato,K. and Shimada,I.
    N-glycan structures of murine hippocampus serine protease, neuropsin, produced in Trichoplusia ni cells
    Glycoconj J (1999) 16, 405-414. PubMed  Europe PubMed DOI  E
  95. [YEAR:10-4-1999]Tomizawa,K., He,X., Yamanaka,H., Shiosaka,S. and Yoshida,S.
    Injury induces neuropsin mRNA in the central nervous system
    Brain Res (10-4-1999) 824, 308-311. PubMed  Europe PubMed DOI
  96. [YEAR:1-9-1999]Underwood,L.J., Tanimoto,H., Wang,Y., Shigemasa,K., Parmley,T.H. and O'Brien,T.J.
    Cloning of tumor-associated differentially expressed gene-14, a novel serine protease overexpressed by ovarian carcinoma
    Cancer Res (1-9-1999) 59, 4435-4439. PubMed  Europe PubMed
    97. 1998
  97. Chen,Z.L., Momota,Y., Kato,K., Taniguchi,M., Inoue,N., Shiosaka,S. and Yoshida,S.
    Expression of neuropsin mRNA in the mouse embryo and the pregnant uterus
    J Histochem Cytochem (1998) 46, 313-320. PubMed  Europe PubMed
  98. Inoue,N., Kuwae,K., Ishida-Yamamoto,A., Iizuka,H., Shibata,M., Yoshida,S., Kato,K. and Shiosaka,S.
    Expression of neuropsin in the keratinizing epithelial tissue - Immunohistochemical analysis of wild-type and nude mice
    J Invest Dermatol (1998) 110, 923-931. PubMed  Europe PubMed DOI
  99. Momota,Y., Yoshida,S., Ito,J., Shibata,M., Kato,K., Sakurai,K., Matsumoto,K. and Shiosaka,S.
    Blockade of neuropsin, a serine protease, ameliorates kindling epilepsy
    Eur J Neurosci (1998) 10, 760-764. PubMed  Europe PubMed DOI
  100. [YEAR:1-5-1998]Shimizu,C., Yoshida,S., Shibata,M., Kato,K., Momota,Y., Matsumoto,K., Shiosaka,T., Midorikawa,R., Kamachi,T., Kawabe,A. and Shiosaka,S.
    Characterization of recombinant and brain neuropsin, a plasticity-related serine protease
    J Biol Chem (1-5-1998) 273, 11189-11196. PubMed  Europe PubMed DOI
  101. [YEAR:15-6-1998]Yoshida,S., Taniguchi,M., Hirata,A. and Shiosaka,S.
    Sequence analysis and expression of human neuropsin cDNA and gene
    Gene (15-6-1998) 213, 9-16. PubMed  Europe PubMed DOI
    102. 1997
  102. Akita,H., Matsuyama,T., Iso,H., Sugita,M. and Yoshida,S.
    Effects of oxidative stress on the expression of limbic-specific protease neuropsin and avoidance learning in mice
    Brain Res (1997) 769, 86-96. PubMed  Europe PubMed DOI
  103. Kishi,T., Kato,M., Shimizu,T., Kato,K., Matsumoto,K., Yoshida,S., Shiosaka,S. and Hakoshima,T.
    Crystallization and preliminary X-ray analysis of neuropsin, a serine protease expressed in the limbic system of mouse brain
    J Struct Biol (1997) 118, 248-251. PubMed  Europe PubMed DOI
    104. 1996
  104. [YEAR:22-7-1996]Okabe,A., Momota,Y., Yoshida,S., Hirata,A., Ito,J., Nishino,H. and Shiosaka,S.
    Kindling induces neuropsin mRNA in the mouse brain
    Brain Res (22-7-1996) 728, 116-120. PubMed  Europe PubMed DOI
    105. 1995
  105. Chen,Z.L., Yoshida,S., Kato,K., Momota,Y., Suzuki,J., Tanaka,T., Ito,J., Nishino,H., Aimoto,S., Kiyama,H. and Shiosaka,S.
    Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus
    J Neurosci (1995) 15, 5088-5097. PubMed  Europe PubMed
  106. Suzuki,J., Yoshida,S., Chen,Z.L., Momota,Y., Kato,K., Hirata,A. and Shiosaka,S.
    Ontogeny of neuropsin mRNA expression in the mouse brain
    Neurosci Res (1995) 23, 345-351. PubMed  Europe PubMed DOI

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