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Literature for peptidase S01.196: complement factor Bb

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, M Mutation, K Knockout, P Specificity, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Kavanagh,D., Barratt,J., Schubart,A., Webb,N.J.A., Meier,M. and Fakhouri,F.
    Factor B as a therapeutic target for the treatment of complement-mediated diseases
    Front Immunol16, 1537974-1537974. PubMed  Europe PubMed DOI  V
    2. 2023
  2. Schubart,A., Flohr,S., Junt,T. and Eder,J.
    Low-molecular weight inhibitors of the alternative complement pathway
    Immunol Rev313, 339-357. PubMed  Europe PubMed DOI
    3. 2022
  3. Laich,A., Patel,H., Zarantonello,A., Sim,R.B. and Inal,J.M.
    C2 by-pass: Cross-talk between the complement classical and alternative pathways
    Immunobiology227, 152225-152225. PubMed  Europe PubMed DOI
  4. Lorentzen,J., Pedersen,D.V., Gadeberg,T.A.F. and Andersen,G.R.
    Structure determination of an unstable macromolecular complex enabled by nanobody-peptide bridging
    Protein Sci31, e4432-e4432. PubMed  Europe PubMed DOI
    5. 2021
  5. Takahashi,K., Banda,N.K., Holers,V.M. and Van Cott,E.M.
    Complement component factor B has thrombin-like activity
    Biochem Biophys Res Commun552, 17-22. PubMed  Europe PubMed DOI
    6. 2020
  6. Mainolfi,N., Ehara,T., Karki,R.G., Anderson,K., Mac Sweeney,A., Liao,S.M., Argikar,U.A., Jendza,K., Zhang,C., Powers,J., Klosowski,D.W., Crowley,M., Kawanami,T., Ding,J., April,M., Forster,C., Serrano-Wu,M., Capparelli,M., Ramqaj,R., Solovay,C., Cumin,F., Smith,T.M., Ferrara,L., Lee,W., Long,D., Prentiss,M., de Erkenez,A., Yang,L., Liu,F., Sellner,H., Sirockin,F., Valeur,E., Erbel,P., Ostermeier,D., Ramage,P., Gerhartz,B., Schubart,A., Flohr,S., Gradoux,N., Feifel,R., Vogg,B., Wiesmann,C., Maibaum,J., Eder,J., Sedrani,R., Harrison,R.A., Mogi,M., Jaffee,B.D. and Adams,C.M.
    Discovery of 4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic acid (LNP023), a factor B inhibitor specifically designed to be applicable to treating a diverse array of complement mediated diseases
    J Med Chem PubMed  Europe PubMed DOI  I
    7. 2019
  7. Peng,M., Li,Z., Niu,D., Liu,X., Dong,Z. and Li,J.
    Complement factor B/C2 in molluscs regulates agglutination and illuminates evolution of the Bf/C2 family
    FASEB J33, 13323-13333. PubMed  Europe PubMed DOI
  8. Schubart,A., Anderson,K., Mainolfi,N., Sellner,H., Ehara,T., Adams,C.M., Mac Sweeney,A., Liao,S.M., Crowley,M., Littlewood-Evans,A., Sarret,S., Wieczorek,G., Perrot,L., Dubost,V., Flandre,T., Zhang,Y., Smith,R.J.H., Risitano,A.M., Karki,R.G., Zhang,C., Valeur,E., Sirockin,F., Gerhartz,B., Erbel,P., Hughes,N., Smith,T.M., Cumin,F., Argikar,U.A., Haraldsson,B., Mogi,M., Sedrani,R., Wiesmann,C., Jaffee,B., Maibaum,J., Flohr,S., Harrison,R. and Eder,J.
    Small-molecule factor B inhibitor for the treatment of complement-mediated diseases
    Proc Natl Acad Sci U S A116, 7926-7931. PubMed  Europe PubMed DOI  I
    9. 2013
  9. Slade,C., Bosco,J., Unglik,G., Bleasel,K., Nagel,M. and Winship,I.
    Deficiency in complement factor B
    N Engl J Med369, 1667-1669. PubMed  Europe PubMed DOI  M
    10. 2012
  10. Forneris,F., Wu,J. and Gros,P.
    The modular serine proteases of the complement cascade
    Curr Opin Struct Biol22, 333-341. PubMed  Europe PubMed DOI  V
  11. Kerr,M.A.
    Factor B and the alternative pathway C3/C5 convertase
    [ISSN:978-0-12-407742-3]3, 2869-2875. DOI
    12. 2011
  12. Laursen,N.S., Andersen,K.R., Braren,I., Spillner,E., Sottrup-Jensen,L. and Andersen,G.R.
    Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex
    EMBO J30, 606-616. PubMed  Europe PubMed DOI
    13. 2010
  13. Forneris,F., Ricklin,D., Wu,J., Tzekou,A., Wallace,R.S., Lambris,J.D. and Gros,P.
    Structures of C3b in complex with factors B and D give insight into complement convertase formation
    Science330, 1816-1820. PubMed  Europe PubMed DOI
    14. 2009
  14. Krishnan,V., Ponnuraj,K., Xu,Y., Macon,K., Volanakis,J.E. and Narayana,S.V.
    The crystal structure of cobra venom factor, a cofactor for C3- and C5-convertase CVFBb
    Structure17, 611-619. PubMed  Europe PubMed DOI
  15. Rooijakkers,S.H., Wu,J., Ruyken,M., van Domselaar,R., Planken,K.L., Tzekou,A., Ricklin,D., Lambris,J.D., Janssen,B.J., van Strijp,J.A. and Gros,P.
    Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor
    Nat Immunol10, 721-727. PubMed  Europe PubMed DOI  S
  16. Ruiz-Gomez,G., Lim,J., Halili,M.A., Le,G.T., Madala,P.K., Abbenante,G. and Fairlie,D.P.
    Structure-activity relationships for substrate-based inhibitors of human complement factor B
    J Med Chem52, 6042-6052. PubMed  Europe PubMed DOI  I
  17. Torreira,E., Tortajada,A., Montes,T., Rodriguez de Cordoba,S. and Llorca,O.
    3D structure of the C3bB complex provides insights into the activation and regulation of the complement alternative pathway convertase
    Proc Natl Acad Sci U S A106, 882-887. PubMed  Europe PubMed DOI
    18. 2008
  18. Bexborn,F., Andersson,P.O., Chen,H., Nilsson,B. and Ekdahl,K.N.
    The tick-over theory revisited: formation and regulation of the soluble alternative complement C3 convertase (C3(H2O)Bb)
    Mol Immunol45, 2370-2379. PubMed  Europe PubMed DOI
    19. 2007
  19. Goicoechea de Jorge,E., Harris,C.L., Esparza-Gordillo,J., Carreras,L., Arranz,E.A., Garrido,C.A., Lopez-Trascasa,M., Sanchez-Corral,P., Morgan,B.P. and Rodriguez,D.C.
    Gain-of-function mutations in complement factor B are associated with atypical hemolytic uremic syndrome
    Proc Natl Acad Sci USA104, 240-245. PubMed  Europe PubMed DOI  M
  20. Harris,C.L., Pettigrew,D.M., Lea,S.M. and Morgan,B.P.
    Decay-accelerating factor must bind both components of the complement alternative pathway C3 convertase to mediate efficient decay
    J Immunol178, 352-359. PubMed  Europe PubMed
  21. Le,G.T., Abbenante,G. and Fairlie,D.P.
    Profiling the enzymatic properties and inhibition of human complement factor B
    J Biol Chem282, 34809-34816. PubMed  Europe PubMed DOI  A  P  I
  22. Milder,F.J., Gomes,L., Schouten,A., Janssen,B.J., Huizinga,E.G., Romijn,R.A., Hemrika,W., Roos,A., Daha,M.R. and Gros,P.
    Factor B structure provides insights into activation of the central protease of the complement system
    Nat Struct Mol Biol14, 224-228. PubMed  Europe PubMed DOI  S
    23. 2005
  23. Yoshizaki,F.Y., Ikawa,S., Satake,M., Satoh,N. and Nonaka,M.
    Structure and the evolutionary implication of the triplicated complement factor B genes of a urochordate ascidian, Ciona intestinalis
    Immunogenetics56, 930-942. PubMed  Europe PubMed DOI
    24. 2004
  24. Bhattacharya,A.A., Lupher,M.L., Jr., Staunton,D.E. and Liddington,R.C.
    Crystal structure of the A domain from complement factor B reveals an integrin-like open conformation
    Structure12, 371-378. PubMed  Europe PubMed DOI
  25. Kerr,M.A.
    Factor B and the alternative pathway C3/C5 convertase
    [ISSN:0-12-079610-4]2, 1632-1637.  V
  26. [YEAR:9-4-2004]Ponnuraj,K., Xu,Y., Macon,K., Moore,D., Volanakis,J.E. and Narayana,S.V.
    Structural analysis of engineered Bb fragment of complement factor B: insights into the activation mechanism of the alternative pathway C3-convertase
    Mol Cell14, 17-28. PubMed  Europe PubMed DOI  S
    27. 2002
  27. Nakao,M., Matsumoto,M., Nakazawa,M., Fujiki,K. and Yano,T.
    Diversity of complement factor B/C2 in the common carp (Cyprinus carpio): three isotypes of B/C2-A expressed in different tissues
    Dev Comp Immunol26, 533-541. PubMed  Europe PubMed DOI
    28. 2001
  28. Xu,Y., Narayana,S.V. and Volanakis,J.E.
    Structural biology of the alternative pathway convertase
    Immunol Rev180, 123-135. PubMed  Europe PubMed DOI
    29. 2000
  29. [YEAR:1-9-2000]Hinshelwood,J. and Perkins,S.J.
    Conformational changes during the assembly of factor B from its domains by (1)H NMR spectroscopy and molecular modelling: their relevance to the regulation of factor B activity
    J Mol Biol301, 1267-1285. PubMed  Europe PubMed DOI
  30. [YEAR:21-4-2000]Hinshelwood,J. and Perkins,S.J.
    Metal-dependent conformational changes in a recombinant vWF-A domain from human factor B: a solution study by circular dichroism, fourier transform infrared and (1)H NMR spectroscopy
    J Mol Biol298, 135-147. PubMed  Europe PubMed DOI
  31. [YEAR:17-1-2000]Jing,H., Xu,Y.Y., Carson,M., Moore,D., Macon,K.J., Volanakis,J.E. and Narayana,S.V.L.
    New structural motifs on the chymotrypsin fold and their potential roles in complement factor B
    EMBO J19, 164-173. PubMed  Europe PubMed DOI  S
  32. Sim,R.B. and Laich,A.
    Serine proteases of the complement system
    Biochem Soc Trans28, 545-550. PubMed  Europe PubMed
  33. [YEAR:7-1-2000]Xu,Y., Circolo,A., Jing,H., Wang,Y., Narayana,S.V. and Volanakis,J.E.
    Mutational analysis of the primary substrate specificity pocket of complement factor B. Asp(226) is a major structural determinant for P(1)-Arg binding
    J Biol Chem275, 378-385. PubMed  Europe PubMed DOI
    34. 1999
  34. [YEAR:1-3-1999]Hourcade,D.E., Mitchell,L.M. and Oglesby,T.J.
    Mutations of the type A domain of complement factor B that promote high-affinity C3b-binding
    J Immunol162, 2906-2911. PubMed  Europe PubMed
    35. 1998
  35. Geserick,G., Otremba,P., Schroder,H., Stradmann-Bellinghausen,B. and Schneider,P.M.
    Reference typing report for complement factor B
    Exp Clin Immunogenet15, 261-263. PubMed  Europe PubMed
  36. [YEAR:2-10-1998]Hourcade,D.E., Mitchell,L.M. and Oglesby,T.J.
    A conserved element in the serine protease domain of complement factor B
    J Biol Chem273, 25996-26000. PubMed  Europe PubMed DOI
  37. [YEAR:16-1-1998]Taylor,P.R., Nash,J.T., Theodoridis,E., Bygrave,A.E., Walport,M.J. and Botto,M.
    A targeted disruption of the murine complement factor B gene resulting in loss of expression of three genes in close proximity, factor B, C2, and D17H6S45
    J Biol Chem273, 1699-1704. PubMed  Europe PubMed DOI  K
    38. 1994
  38. Fritzinger,D.C., Bredehorst,R. and Vogel,C.W.
    Molecular cloning and derived primary structure of cobra venom factor
    Proc Natl Acad Sci U S A91, 12775-12779. PubMed  Europe PubMed DOI
  39. [YEAR:15-11-1994]Kato,Y., Salter-Cid,L., Flajnik,M.F., Kasahara,M., Namikawa,C., Sasaki,M. and Nonaka,M.
    Isolation of the Xenopus complement factor B complementary DNA and linkage of the gene to the frog MHC
    J Immunol153, 4546-4554. PubMed  Europe PubMed
  40. [YEAR:6-7-1993]
    Nomenclature for human complement factor B. WHO-IUIS Nomenclature Sub-Committee
    J Immunol Methods163, 9-11. PubMed  Europe PubMed DOI
    41. 1993
  41. Horiuchi,T., Kim,S., Matsumoto,M., Watanabe,I., Fujita,S. and Volanakis,J.E.
    Human complement factor B: cDNA cloning, nucleotide sequencing, phenotypic conversion by site-directed mutagenesis and expression
    Mol Immunol30, 1587-1592. PubMed  Europe PubMed DOI
  42. [YEAR:15-10-1993]Kjalke,M., Welinder,K.G. and Koch,C.
    Structural analysis of chicken factor B-like protease and comparison with mammalian complement proteins factor B and C2
    J Immunol151, 4147-4152. PubMed  Europe PubMed
  43. [YEAR:1-10-1993]Perkins,S.J. and Smith,K.F.
    Identity of the putative serine-proteinase fold in proteins of the complement system with nine relevant crystal structures
    Biochem J295, 109-114. PubMed  Europe PubMed  S
  44. Schwaeble,W., Luttig,B., Sokolowski,T., Estaller,C., Weiss,E.H., Meyer zum Buschenfelde,K.H., Whaley,K. and Dippold,W.
    Human complement factor B: functional properties of a recombinant zymogen of the alternative activation pathway convertase
    Immunobiology188, 221-232. PubMed  Europe PubMed DOI
    45. 1992
  45. Kam,C.M., Oglesby,T.J., Pangburn,M.K., Volanakis,J.E. and Powers,J.C.
    Substituted isocoumarins as inhibitors of complement serine proteases
    J Immunol149, 163-168. PubMed  Europe PubMed  I
    46. 1991
  46. [YEAR:1-3-1991]Niemann,M.A., Bhown,A.S. and Miller,E.J.
    The principal site of glycation of human complement factor B
    Biochem J274, 473-480. PubMed  Europe PubMed
    47. 1990
  47. Sanchez-Corral,P., Anton,L.C., Alcolea,J.M., Marques,G., Sanchez,A. and Vivanco,F.
    Proteolytic activity of the different fragments of factor B on the third component of complement (C3). Involvement of the N-terminal domain of Bb in magnesium binding
    Mol Immunol27, 891-900. PubMed  Europe PubMed DOI
  48. Volanakis,J.E.
    Participation of C3 and its ligands in complement activation
    Curr Top Microbiol Immunol153, 1-21. PubMed  Europe PubMed
    49. 1987
  49. [YEAR:15-3-1987]Kam,C.M., McRae,B.J., Harper,J.W., Niemann,M.A., Volanakis,J.E. and Powers,J.C.
    Human complement proteins D, C2, and B. Active site mapping with peptide thioester substrates
    J Biol Chem262, 3444-3451. PubMed  Europe PubMed
    50. 1983
  50. Campbell,R.D. and Porter,R.R.
    Molecular cloning and characterization of the gene coding for human complement protein factor B
    Proc Natl Acad Sci U S A80, 4464-4468. PubMed  Europe PubMed
    51. 1982
  51. [YEAR:10-9-1982]Smith,C.A., Vogel,C.W. and Muller-Eberhard,H.J.
    Ultrastructure of cobra venom factor-dependent C3/C5 convertase and its zymogen, factor B of human complement
    J Biol Chem257, 9879-9882. PubMed  Europe PubMed
    52. 1981
  52. Kerr,M.A.
    Human factor B
    Methods Enzymol80, 102-112. PubMed  Europe PubMed DOI  V

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