Substrates for peptidase S01.147: granzyme H

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Boc-Ala-Ala-Met-SBzl Boc-Ala-Ala-Met+SBzl S Boc Ala Ala Met SBz - - - Edwards et al., 1999
Boc-Ala-Ala-Nle-SBzl Boc-Ala-Ala-Nle+SBzl S Boc Ala Ala Nle SBz - - - Edwards et al., 1999
Boc-Ala-Ala-Nva-SBzl Boc-Ala-Ala-Nva+SBzl S Boc Ala Ala Nva SBz - - - Edwards et al., 1999
Boc-Ala-Ala-Phe-SBzl Boc-Ala-Ala-Phe+SBzl S Boc Ala Ala Phe SBz - - - Edwards et al., 1999
Boc-Ala-Ala-Tyr-SBzl Boc-Ala-Ala-Tyr+SBzl S Boc Ala Ala Tyr SBz - - - Edwards et al., 1999
Early E2A DNA-binding protein P03265 1-529 peptide-Met118+Val-peptide P MU Ala Leu Gln Met Val Gly Phe Ser Andrade et al., 2007
lupus La protein P05455 1-408 peptide-Phe364+Ala-peptide P Lys Thr Lys Phe Ala Ser Asp Asp Romero et al., 2008
Suc-Phe-Leu-Phe-SBzl Suc-Phe-Leu-Phe+SBzl S Suc Phe Leu Phe SBz - - - Edwards et al., 1999