Substrates for peptidase S01.034: transmembrane peptidase, serine 4

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
scnn1a sodium channel, nonvoltage-gated, type I, alpha P37089 1-698 peptide-Lys150+Leu-peptide P Asn Ser Asp Lys Leu Val Phe Pro Garcia-Caballero et al., 2008 26755
scnn1a sodium channel, nonvoltage-gated, type I, alpha P37089 1-698 peptide-Arg165+Tyr-peptide P Asn Pro Tyr Arg Tyr Thr Glu Ile Garcia-Caballero et al., 2008 26756
scnn1a sodium channel, nonvoltage-gated, type I, alpha P37089 1-698 peptide-Lys170+Glu-peptide P Thr Glu Ile Lys Glu Glu Leu Glu Garcia-Caballero et al., 2008 26757
scnn1a sodium channel, nonvoltage-gated, type I, alpha P37089 1-698 peptide-Arg178+Ile-peptide P Glu Leu Asp Arg Ile Thr Glu Gln Garcia-Caballero et al., 2008 26758
scnn1a sodium channel, nonvoltage-gated, type I, alpha P37089 1-698 peptide-Arg206+Asp-peptide P Arg Ser Ser Arg Asp Leu Leu Gly Garcia-Caballero et al., 2008 26759
scnn1a sodium channel, nonvoltage-gated, type I, alpha P37089 1-698 peptide-Arg232+Ser-peptide P Arg Thr Ala Arg Ser Gly Ser Ser Garcia-Caballero et al., 2008 26760
scnn1a sodium channel, nonvoltage-gated, type I, alpha P37089 1-698 peptide-Lys562+Thr-peptide P Leu Asn Tyr Lys Thr Asn Ser Glu Garcia-Caballero et al., 2008 26761
scnn1b sodium channel, nonvoltage-gated 1 beta P37090 1-638 peptide-Arg503+Thr-peptide P Phe Asn Tyr Arg Thr Ile Glu Glu Garcia-Caballero et al., 2008 26762
scnn1g sodium channel, nonvoltage-gated 1 gamma P37091 1-650 peptide-Arg138+Glu-peptide P Arg Lys Arg Arg Glu Ala Gly Ser Garcia-Caballero et al., 2008 26763
scnn1g sodium channel, nonvoltage-gated 1 gamma P37091 1-650 peptide-Arg515+Ser-peptide P Leu Asn Gln Arg Ser Ile Met Glu Garcia-Caballero et al., 2008 26764