$VAR1 = undef;

Summary for peptidase S01.034: transmembrane peptidase, serine 4

Names
MEROPS Name	transmembrane peptidase, serine 4
Other names	CAP2, channel-activating protease 2, membrane type serine protease 2, MT-SP2 protease, TMPRSS4 g.p. (Homo sapiens), transmembrane protease, serine 4

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.034
Holotype	transmembrane peptidase, serine 4 (Homo sapiens), Uniprot accession Q9NRS4 (peptidase unit: 205-436), MERNUM MER0011104
History	Identifier created: MEROPS 5.0 (17 April 2000)

Activity
Catalytic type	Serine
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (10 cleavages)
Activity status	human: putative mouse: putative
Pathways	KEGG	Influenza A
Other databases	TREEFAM	http://www.treefam.org/family/TF351678
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	r/-/-/Rk-/-/e/e (based on 10 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	0	0	0	0	1	1	1
Pro	0	1	0	0	0	0	0	1
Ala	0	0	1	0	0	1	0	0
Val	0	0	0	0	0	1	0	0
Leu	2	1	0	0	1	1	2	0
Ile	0	0	1	0	1	2	0	1
Met	0	0	0	0	0	0	1	0
Phe	1	0	0	0	0	0	1	0
Tyr	0	0	3	0	1	0	0	0
Trp	0	0	0	0	0	0	0	0
Ser	0	2	1	0	2	0	2	2
Thr	1	1	0	0	2	2	0	0
Cys	0	0	0	0	0	0	0	0
Asn	2	3	0	0	0	1	0	0
Gln	0	0	1	0	0	0	0	1
Asp	0	0	2	0	1	0	0	0
Glu	1	1	0	0	2	1	3	4
Lys	0	1	0	3	0	0	0	0
Arg	3	0	1	7	0	0	0	0
His	0	0	0	0	0	0	0	0