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Literature for peptidase S01.034: transmembrane peptidase, serine 4

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: M Mutation, T Target, R Splicing, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Tazawa,H., Ishida,Y., Suzuki,T., Shimizu,Y. and Tashiro,H.
    Delivery of lipid nanoparticles containing small interfering RNA targeting transmembrane serine protease 4 in a human gastric cancer model using nude mice
    Sci Rep (2025) 15, 45053-45053. PubMed  Europe PubMed DOI  PMC  EPMC  K
    2. 2023
  2. Feng,H., Yao,L., Zeng,Z., Jiang,L., Shang,Y., Wang,H., Li,L., Wang,Z., Wang,X., Yang,H., Zhao,Q., Ren,X., Zhang,T., Zhang,R., Guo,Y., Lu,Q., Hu,Q., Zhang,W., Ding,C., Shao,H., Cheng,G., Luo,Q. and Wen,G.
    Identification of Embryonic Chicken Proteases Activating Newcastle Disease Virus and Their Roles in the Pathogenicity of Virus Used as In Ovo Vaccine
    J Virol (2023) 97, e0032423-e0032423. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Kim,S.
    TMPRSS4, a type II transmembrane serine protease, as a potential therapeutic target in cancer
    Exp Mol Med (2023) 55, 716-724. PubMed  Europe PubMed DOI  PMC  EPMC  V
    4. 2022
  4. Kerslake,R., Randeva,H.S., Jonigk,D., Werlein,C., Robertus,J.L., Katopodis,P., Jasker,P., Spandidos,D.A., Kyrou,I. and Karteris,E.
    Protein expression of transmembrane protease serine 4 in the gastrointestinal tract and in healthy, cancer, and SARSCoV2 infected lungs
    Mol Med Rep (2022) 25 PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2020
  5. Dong,Z.R., Sun,D., Yang,Y.F., Zhou,W., Wu,R., Wang,X.W., Shi,K., Yan,Y.C., Yan,L.J., Yao,C.Y., Chen,Z.Q., Zhi,X.T. and Li,T.
    TMPRSS4 Drives angiogenesis in hepatocellular carcinoma by promoting HB-EGF expression and proteolytic cleavage
    Hepatology (2020) 72, 923-939. PubMed  Europe PubMed DOI
  6. Voinsky,I. and Gurwitz,D.
    Smoking and COVID-19: Similar bronchial ACE2 and TMPRSS2 expression and higher TMPRSS4 expression in current versus never smokers
    Drug Dev Res (2020) 81, 1073-1080. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Wruck,W. and Adjaye,J.
    SARS-CoV-2 receptor ACE2 is co-expressed with genes related to transmembrane serine proteases, viral entry, immunity and cellular stress
    Sci Rep (2020) 10, 21415-21415. PubMed  Europe PubMed DOI  PMC  EPMC
    8. 2019
  8. Keppner,A., Maric,D., Sergi,C., Ansermet,C., De Bellis,D., Kratschmar,D.V., Canonica,J., Klusonova,P., Fenton,R.A., Odermatt,A., Crambert,G., Hoogewijs,D. and Hummler,E.
    Deletion of the serine protease CAP2/Tmprss4 leads to dysregulated renal water handling upon dietary potassium depletion
    Sci Rep (2019) 9, 19540-19540. PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2018
  9. Jianwei,Z., Qi,L., Quanquan,X., Tianen,W. and Qingwei,W.
    TMPRSS4 Upregulates TWIST1 expression through STAT3 activation to induce prostate cancer cell migration
    Pathol Oncol Res (2018) 24, 251-257. PubMed  Europe PubMed DOI
    10. 2017
  10. Li,X.M., Liu,W.L., Chen,X., Wang,Y.W., Shi,D.B., Zhang,H., Ma,R.R., Liu,H.T., Guo,X.Y., Hou,F., Li,M. and Gao,P.
    Overexpression of TMPRSS4 promotes tumor proliferation and aggressiveness in breast cancer
    Int J Mol Med (2017) 39, 927-935. PubMed  Europe PubMed DOI
  11. Seo,B.R., Min,K.J., Woo,S.M., Choe,M., Choi,K.S., Lee,Y.K., Yoon,G. and Kwon,T.K.
    Inhibition of cathepsin S induces mitochondrial ROS that sensitizes TRAIL-mediated apoptosis through p53-mediated downregulation of Bcl-2 and c-FLIP
    Antioxid Redox Signal (2017) 27, 215-233. PubMed  Europe PubMed DOI  I
  12. Tanabe,L.M. and List,K.
    The role of type II transmembrane serine protease-mediated signaling in cancer
    FEBS J (2017) 284, 1421-1436. PubMed  Europe PubMed DOI  I
    13. 2016
  13. de Aberasturi,A.L., Redrado,M., Villalba,M., Larzabal,L., Pajares,M.J., Garcia,J., Evans,S.R., Garcia-Ros,D., Bodegas,M.E., Lopez,L., Montuenga,L. and Calvo,A.
    TMPRSS4 induces cancer stem cell-like properties in lung cancer cells and correlates with ALDH expression in NSCLC patients
    Cancer Lett (2016) 370, 165-176. PubMed  Europe PubMed DOI
  14. Ilamathi,M., Hemanth,R., Nishanth,S. and Sivaramakrishnan,V.
    Identification of potential transmembrane protease serine 4 inhibitors as anti-cancer agents by integrated computational approach
    J Theor Biol (2016) 389, 253-262. PubMed  Europe PubMed DOI  T  I
  15. Kuhn,N., Bergmann,S., Kosterke,N., Lambertz,R.L., Keppner,A., van den Brand,J.M., Pohlmann,S., Weiss,S., Hummler,E., Hatesuer,B. and Schughart,K.
    The proteolytic activation of (H3N2) influenza A virus hemagglutinin is facilitated by different type II transmembrane serine proteases
    J Virol (2016) 90, 4298-4307. PubMed  Europe PubMed DOI
    16. 2015
  16. de Aberasturi,A.L. and Calvo,A.
    TMPRSS4: an emerging potential therapeutic target in cancer
    Br J Cancer (2015) 112, 4-8. PubMed  Europe PubMed DOI  T
    17. 2014
  17. Larzabal,L., de Aberasturi,A.L., Redrado,M., Rueda,P., Rodriguez,M.J., Bodegas,M.E., Montuenga,L.M. and Calvo,A.
    TMPRSS4 regulates levels of integrin alpha5 in NSCLC through miR-205 activity to promote metastasis
    Br J Cancer (2014) 110, 764-774. PubMed  Europe PubMed DOI
  18. Min,H.J., Lee,Y., Zhao,X.F., Park,Y.K., Lee,M.K., Lee,J.W. and Kim,S.
    TMPRSS4 upregulates uPA gene expression through JNK signaling activation to induce cancer cell invasion
    Cell Signal (2014) 26, 398-408. PubMed  Europe PubMed DOI
  19. Min,H.J., Lee,M.K., Lee,J.W. and Kim,S.
    TMPRSS4 induces cancer cell invasion through pro-uPA processing
    Biochem Biophys Res Commun (2014) 446, 1-7. PubMed  Europe PubMed DOI
  20. Shi,G., Yang,X., Dai,B., Zhang,H., Shen,Y., Zhu,Y., Zhu,Y., Xiao,W., Ma,C., Wen,L., Qin,X., Cao,D. and Ye,D.
    Clinical significance of TMPRSS4 in prostate cancer
    Int J Clin Exp Pathol (2014) 7, 8053-8058. PubMed  Europe PubMed
    21. 2013
  21. Kang,S., Min,H.J., Kang,M.S., Jung,M.G. and Kim,S.
    Discovery of novel 2-hydroxydiarylamide derivatives as TMPRSS4 inhibitors
    Bioorg Med Chem Lett (2013) 23, 1748-1751. PubMed  Europe PubMed DOI  I
  22. Lahiry,P., Racacho,L., Wang,J., Robinson,J., Gloor,G.B., Rupar,C.A., Siu,V.M., Bulman,D.E. and Hegele,R.A.
    A mutation in the serine protease TMPRSS4 in a novel pediatric neurodegenerative disorder
    Orphanet J Rare Dis (2013) 8, 126-126. PubMed  Europe PubMed DOI  M
  23. Takahashi,T., Uehara,H. and Izumi,K.
    Inhibitory effect of soluble EP2 receptor on ovarian tumor growth in nude mice and utility of TMPRSS4 as a combinatorial molecular target
    Int J Oncol (2013) 43, 416-424. PubMed  Europe PubMed DOI  T
    24. 2012
  24. Ohler,A. and Becker-Pauly,C.
    TMPRSS4 is a type II transmembrane serine protease involved in cancer and viral infections
    Biol Chem (2012) 393, 907-914. PubMed  Europe PubMed DOI  V
  25. Passero,C.J., Mueller,G.M., Myerburg,M.M., Carattino,M.D., Hughey,R.P. and Kleyman,T.R.
    TMPRSS4-dependent activation of the epithelial sodium channel requires cleavage of the gamma-subunit distal to the furin cleavage site
    Am J Physiol Renal Physiol (2012) 302, F1-F8. PubMed  Europe PubMed DOI
    26. 2011
  26. Antalis,T.M., Bugge,T.H. and Wu,Q.
    Membrane-anchored serine proteases in health and disease
    Prog Mol Biol Transl Sci (2011) 99, 1-50. PubMed  Europe PubMed DOI  V
  27. Ohler,A. and Becker-Pauly,C.
    Morpholino knockdown of the ubiquitously expressed transmembrane serine protease TMPRSS4a in zebrafish embryos exhibits severe defects in organogenesis and cell adhesion
    Biol Chem (2011) 392, 653-664. PubMed  Europe PubMed DOI  K
    28. 2010
  28. Bertram,S., Glowacka,I., Blazejewska,P., Soilleux,E., Allen,P., Danisch,S., Steffen,I., Choi,S.Y., Park,Y., Schneider,H., Schughart,K. and Pohlmann,S.
    TMPRSS2 and TMPRSS4 facilitate trypsin-independent spread of influenza virus in Caco-2 cells
    J Virol (2010) 84, 10016-10025. PubMed  Europe PubMed DOI
  29. Bertram,S., Glowacka,I., Steffen,I., Kuhl,A. and Pohlmann,S.
    Novel insights into proteolytic cleavage of influenza virus hemagglutinin
    Rev Med Virol (2010) 20, 298-310. PubMed  Europe PubMed DOI
  30. Kim,S., Kang,H.Y., Nam,E.H., Choi,M.S., Zhao,X.F., Hong,C.S., Lee,J.W., Lee,J.H. and Park,Y.K.
    TMPRSS4 induces invasion and epithelial-mesenchymal transition through upregulation of integrin alpha5 and its signaling pathways
    Carcinogenesis (2010) 31, 597-606. PubMed  Europe PubMed DOI
    31. 2009
  31. Chaipan,C., Kobasa,D., Bertram,S., Glowacka,I., Steffen,I., Tsegaye,T.S., Takeda,M., Bugge,T.H., Kim,S., Park,Y., Marzi,A. and Pohlmann,S.
    Proteolytic activation of the 1918 influenza virus hemagglutinin
    J Virol (2009) 83, 3200-3211. PubMed  Europe PubMed DOI  PMC  EPMC
    32. 2008
  32. Garcia-Caballero,A., Dang,Y., He,H. and Stutts,M.J.
    ENaC Proteolytic regulation by channel-activating protease 2
    J Gen Physiol (2008) 132, 521-535. PubMed  Europe PubMed DOI  PMC  EPMC
  33. Jung,H., Lee,K.P., Park,S.J., Park,J.H., Jang,Y.S., Choi,S.Y., Jung,J.G., Jo,K., Park,D.Y., Yoon,J.H., Park,J.H., Lim,D.S., Hong,G.R., Choi,C., Park,Y.K., Lee,J.W., Hong,H.J., Kim,S. and Park,Y.W.
    TMPRSS4 promotes invasion, migration and metastasis of human tumor cells by facilitating an epithelial-mesenchymal transition
    Oncogene (2008) 27, 2635-2647. PubMed  Europe PubMed DOI
    34. 2007
  34. Planes,C. and Caughey,G.H.
    Regulation of the epithelial Na+ channel by peptidases
    Curr Top Dev Biol (2007) 78, 23-46. PubMed  Europe PubMed DOI  PMC  EPMC
    35. 2006
  35. [YEAR:8-3-2006]Andreasen,D., Vuagniaux,G., Fowler-Jaeger,N., Hummler,E. and Rossier,B.C.
    Activation of epithelial sodium channels by mouse channel activating proteases (mCAP) expressed in Xenopus oocytes requires catalytic activity of mCAP3 and mCAP2 but not mCAP1
    J Am Soc Nephrol (8-3-2006) 17, 968-976. PubMed  Europe PubMed DOI
  36. Kleyman,T.R., Myerburg,M.M. and Hughey,R.P.
    Regulation of ENaCs by proteases: an increasingly complex story
    Kidney Int (2006) 70, 1391-1392. PubMed  Europe PubMed DOI
    37. 2005
  37. Kebebew,E., Peng,M., Reiff,E., Duh,Q.Y., Clark,O.H. and McMillan,A.
    ECM1 and TMPRSS4 are diagnostic markers of malignant thyroid neoplasms and improve the accuracy of fine needle aspiration biopsy
    Ann Surg (2005) 242, 353-361. PubMed  Europe PubMed DOI  PMC  EPMC
  38. Yamada,H., Shinmura,K., Tsuneyoshi,T. and Sugimura,H.
    Effect of splice-site polymorphisms of the TMPRSS4, NPHP4 and ORCTL4 genes on their mRNA expression
    J Genet (2005) 84, 131-136. PubMed  Europe PubMed  R
    39. 2004
  39. [YEAR:10-9-2004]Caldwell,R.A., Boucher,R.C. and Stutts,M.J.
    Serine protease activation of near-silent epithelial Na+ channels
    Am J Physiol Cell Physiol (10-9-2004) 286, C190-C194. PubMed  Europe PubMed DOI
    40. 2003
  40. Szabo,R., Wu,Q., Dickson,R.B., Netzel-Arnett,S., Antalis,T.M. and Bugge,T.H.
    Type II transmembrane serine proteases
    Thromb Haemost (2003) 90, 185-193. PubMed  Europe PubMed DOI  V
    41. 2002
  41. Vuagniaux,G., Vallet,V., Jaeger,N.F., Hummler,E. and Rossier,B.C.
    Synergistic activation of ENaC by three membrane-bound channel-activating serine proteases (mCAP1, mCAP2, and mCAP3) and serum- and glucocorticoid-regulated kinase (Sgk1) in Xenopus oocytes
    J Gen Physiol (2002) 120, 191-201. PubMed  Europe PubMed DOI  PMC  EPMC
    42. 2000
  42. [YEAR:15-5-2000]Wallrapp,C., Hahnel,S., Muller-Pillasch,F., Burghardt,B., Iwamura,T., Ruthenburger,M., Lerch,M.M., Adler,G. and Gress,T.M.
    A novel transmembrane serine protease (TMPRSS3) overexpressed in pancreatic cancer
    Cancer Res (15-5-2000) 60, 2602-2606. PubMed  Europe PubMed

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