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Literature for peptidase S01.034: transmembrane peptidase, serine 4

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: M Mutation, T Target, R Splicing, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Tazawa,H., Ishida,Y., Suzuki,T., Shimizu,Y. and Tashiro,H.<br>Delivery of lipid nanoparticles containing small interfering RNA targeting transmembrane serine protease 4 in a human gastric cancer model using nude mice<br>Sci Rep (2025) 15, 45053-45053. PubMed  Europe PubMed DOI  PMC  EPMC  K
    2. 2023
  2. Feng,H., Yao,L., Zeng,Z., Jiang,L., Shang,Y., Wang,H., Li,L., Wang,Z., Wang,X., Yang,H., Zhao,Q., Ren,X., Zhang,T., Zhang,R., Guo,Y., Lu,Q., Hu,Q., Zhang,W., Ding,C., Shao,H., Cheng,G., Luo,Q. and Wen,G.<br>Identification of Embryonic Chicken Proteases Activating Newcastle Disease Virus and Their Roles in the Pathogenicity of Virus Used as In Ovo Vaccine<br>J Virol (2023) 97, e0032423-e0032423. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Kim,S.<br>TMPRSS4, a type II transmembrane serine protease, as a potential therapeutic target in cancer<br>Exp Mol Med (2023) 55, 716-724. PubMed  Europe PubMed DOI  PMC  EPMC  V
    4. 2022
  4. Kerslake,R., Randeva,H.S., Jonigk,D., Werlein,C., Robertus,J.L., Katopodis,P., Jasker,P., Spandidos,D.A., Kyrou,I. and Karteris,E.<br>Protein expression of transmembrane protease serine 4 in the gastrointestinal tract and in healthy, cancer, and SARSCoV2 infected lungs<br>Mol Med Rep (2022) 25 PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2020
  5. Dong,Z.R., Sun,D., Yang,Y.F., Zhou,W., Wu,R., Wang,X.W., Shi,K., Yan,Y.C., Yan,L.J., Yao,C.Y., Chen,Z.Q., Zhi,X.T. and Li,T.<br>TMPRSS4 Drives angiogenesis in hepatocellular carcinoma by promoting HB-EGF expression and proteolytic cleavage<br>Hepatology (2020) 72, 923-939. PubMed  Europe PubMed DOI
  6. Voinsky,I. and Gurwitz,D.<br>Smoking and COVID-19: Similar bronchial ACE2 and TMPRSS2 expression and higher TMPRSS4 expression in current versus never smokers<br>Drug Dev Res (2020) 81, 1073-1080. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Wruck,W. and Adjaye,J.<br>SARS-CoV-2 receptor ACE2 is co-expressed with genes related to transmembrane serine proteases, viral entry, immunity and cellular stress<br>Sci Rep (2020) 10, 21415-21415. PubMed  Europe PubMed DOI  PMC  EPMC
    8. 2019
  8. Keppner,A., Maric,D., Sergi,C., Ansermet,C., De Bellis,D., Kratschmar,D.V., Canonica,J., Klusonova,P., Fenton,R.A., Odermatt,A., Crambert,G., Hoogewijs,D. and Hummler,E.<br>Deletion of the serine protease CAP2/Tmprss4 leads to dysregulated renal water handling upon dietary potassium depletion<br>Sci Rep (2019) 9, 19540-19540. PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2018
  9. Jianwei,Z., Qi,L., Quanquan,X., Tianen,W. and Qingwei,W.<br>TMPRSS4 Upregulates TWIST1 expression through STAT3 activation to induce prostate cancer cell migration<br>Pathol Oncol Res (2018) 24, 251-257. PubMed  Europe PubMed DOI
    10. 2017
  10. Li,X.M., Liu,W.L., Chen,X., Wang,Y.W., Shi,D.B., Zhang,H., Ma,R.R., Liu,H.T., Guo,X.Y., Hou,F., Li,M. and Gao,P.<br>Overexpression of TMPRSS4 promotes tumor proliferation and aggressiveness in breast cancer<br>Int J Mol Med (2017) 39, 927-935. PubMed  Europe PubMed DOI
  11. Seo,B.R., Min,K.J., Woo,S.M., Choe,M., Choi,K.S., Lee,Y.K., Yoon,G. and Kwon,T.K.<br>Inhibition of cathepsin S induces mitochondrial ROS that sensitizes TRAIL-mediated apoptosis through p53-mediated downregulation of Bcl-2 and c-FLIP<br>Antioxid Redox Signal (2017) 27, 215-233. PubMed  Europe PubMed DOI  I
  12. Tanabe,L.M. and List,K.<br>The role of type II transmembrane serine protease-mediated signaling in cancer<br>FEBS J (2017) 284, 1421-1436. PubMed  Europe PubMed DOI  I
    13. 2016
  13. de Aberasturi,A.L., Redrado,M., Villalba,M., Larzabal,L., Pajares,M.J., Garcia,J., Evans,S.R., Garcia-Ros,D., Bodegas,M.E., Lopez,L., Montuenga,L. and Calvo,A.<br>TMPRSS4 induces cancer stem cell-like properties in lung cancer cells and correlates with ALDH expression in NSCLC patients<br>Cancer Lett (2016) 370, 165-176. PubMed  Europe PubMed DOI
  14. Ilamathi,M., Hemanth,R., Nishanth,S. and Sivaramakrishnan,V.<br>Identification of potential transmembrane protease serine 4 inhibitors as anti-cancer agents by integrated computational approach<br>J Theor Biol (2016) 389, 253-262. PubMed  Europe PubMed DOI  T  I
  15. Kuhn,N., Bergmann,S., Kosterke,N., Lambertz,R.L., Keppner,A., van den Brand,J.M., Pohlmann,S., Weiss,S., Hummler,E., Hatesuer,B. and Schughart,K.<br>The proteolytic activation of (H3N2) influenza A virus hemagglutinin is facilitated by different type II transmembrane serine proteases<br>J Virol (2016) 90, 4298-4307. PubMed  Europe PubMed DOI
    16. 2015
  16. de Aberasturi,A.L. and Calvo,A.<br>TMPRSS4: an emerging potential therapeutic target in cancer<br>Br J Cancer (2015) 112, 4-8. PubMed  Europe PubMed DOI  T
    17. 2014
  17. Larzabal,L., de Aberasturi,A.L., Redrado,M., Rueda,P., Rodriguez,M.J., Bodegas,M.E., Montuenga,L.M. and Calvo,A.<br>TMPRSS4 regulates levels of integrin alpha5 in NSCLC through miR-205 activity to promote metastasis<br>Br J Cancer (2014) 110, 764-774. PubMed  Europe PubMed DOI
  18. Min,H.J., Lee,Y., Zhao,X.F., Park,Y.K., Lee,M.K., Lee,J.W. and Kim,S.<br>TMPRSS4 upregulates uPA gene expression through JNK signaling activation to induce cancer cell invasion<br>Cell Signal (2014) 26, 398-408. PubMed  Europe PubMed DOI
  19. Min,H.J., Lee,M.K., Lee,J.W. and Kim,S.<br>TMPRSS4 induces cancer cell invasion through pro-uPA processing<br>Biochem Biophys Res Commun (2014) 446, 1-7. PubMed  Europe PubMed DOI
  20. Shi,G., Yang,X., Dai,B., Zhang,H., Shen,Y., Zhu,Y., Zhu,Y., Xiao,W., Ma,C., Wen,L., Qin,X., Cao,D. and Ye,D.<br>Clinical significance of TMPRSS4 in prostate cancer<br>Int J Clin Exp Pathol (2014) 7, 8053-8058. PubMed  Europe PubMed
    21. 2013
  21. Kang,S., Min,H.J., Kang,M.S., Jung,M.G. and Kim,S.<br>Discovery of novel 2-hydroxydiarylamide derivatives as TMPRSS4 inhibitors<br>Bioorg Med Chem Lett (2013) 23, 1748-1751. PubMed  Europe PubMed DOI  I
  22. Lahiry,P., Racacho,L., Wang,J., Robinson,J., Gloor,G.B., Rupar,C.A., Siu,V.M., Bulman,D.E. and Hegele,R.A.<br>A mutation in the serine protease TMPRSS4 in a novel pediatric neurodegenerative disorder<br>Orphanet J Rare Dis (2013) 8, 126-126. PubMed  Europe PubMed DOI  M
  23. Takahashi,T., Uehara,H. and Izumi,K.<br>Inhibitory effect of soluble EP2 receptor on ovarian tumor growth in nude mice and utility of TMPRSS4 as a combinatorial molecular target<br>Int J Oncol (2013) 43, 416-424. PubMed  Europe PubMed DOI  T
    24. 2012
  24. Ohler,A. and Becker-Pauly,C.<br>TMPRSS4 is a type II transmembrane serine protease involved in cancer and viral infections<br>Biol Chem (2012) 393, 907-914. PubMed  Europe PubMed DOI  V
  25. Passero,C.J., Mueller,G.M., Myerburg,M.M., Carattino,M.D., Hughey,R.P. and Kleyman,T.R.<br>TMPRSS4-dependent activation of the epithelial sodium channel requires cleavage of the gamma-subunit distal to the furin cleavage site<br>Am J Physiol Renal Physiol (2012) 302, F1-F8. PubMed  Europe PubMed DOI
    26. 2011
  26. Antalis,T.M., Bugge,T.H. and Wu,Q.<br>Membrane-anchored serine proteases in health and disease<br>Prog Mol Biol Transl Sci (2011) 99, 1-50. PubMed  Europe PubMed DOI  V
  27. Ohler,A. and Becker-Pauly,C.<br>Morpholino knockdown of the ubiquitously expressed transmembrane serine protease TMPRSS4a in zebrafish embryos exhibits severe defects in organogenesis and cell adhesion<br>Biol Chem (2011) 392, 653-664. PubMed  Europe PubMed DOI  K
    28. 2010
  28. Bertram,S., Glowacka,I., Blazejewska,P., Soilleux,E., Allen,P., Danisch,S., Steffen,I., Choi,S.Y., Park,Y., Schneider,H., Schughart,K. and Pohlmann,S.<br>TMPRSS2 and TMPRSS4 facilitate trypsin-independent spread of influenza virus in Caco-2 cells<br>J Virol (2010) 84, 10016-10025. PubMed  Europe PubMed DOI
  29. Bertram,S., Glowacka,I., Steffen,I., Kuhl,A. and Pohlmann,S.<br>Novel insights into proteolytic cleavage of influenza virus hemagglutinin<br>Rev Med Virol (2010) 20, 298-310. PubMed  Europe PubMed DOI
  30. Kim,S., Kang,H.Y., Nam,E.H., Choi,M.S., Zhao,X.F., Hong,C.S., Lee,J.W., Lee,J.H. and Park,Y.K.<br>TMPRSS4 induces invasion and epithelial-mesenchymal transition through upregulation of integrin alpha5 and its signaling pathways<br>Carcinogenesis (2010) 31, 597-606. PubMed  Europe PubMed DOI
    31. 2009
  31. Chaipan,C., Kobasa,D., Bertram,S., Glowacka,I., Steffen,I., Tsegaye,T.S., Takeda,M., Bugge,T.H., Kim,S., Park,Y., Marzi,A. and Pohlmann,S.<br>Proteolytic activation of the 1918 influenza virus hemagglutinin<br>J Virol (2009) 83, 3200-3211. PubMed  Europe PubMed DOI  PMC  EPMC
    32. 2008
  32. Garcia-Caballero,A., Dang,Y., He,H. and Stutts,M.J.<br>ENaC Proteolytic regulation by channel-activating protease 2<br>J Gen Physiol (2008) 132, 521-535. PubMed  Europe PubMed DOI  PMC  EPMC
  33. Jung,H., Lee,K.P., Park,S.J., Park,J.H., Jang,Y.S., Choi,S.Y., Jung,J.G., Jo,K., Park,D.Y., Yoon,J.H., Park,J.H., Lim,D.S., Hong,G.R., Choi,C., Park,Y.K., Lee,J.W., Hong,H.J., Kim,S. and Park,Y.W.<br>TMPRSS4 promotes invasion, migration and metastasis of human tumor cells by facilitating an epithelial-mesenchymal transition<br>Oncogene (2008) 27, 2635-2647. PubMed  Europe PubMed DOI
    34. 2007
  34. Planes,C. and Caughey,G.H.<br>Regulation of the epithelial Na+ channel by peptidases<br>Curr Top Dev Biol (2007) 78, 23-46. PubMed  Europe PubMed DOI  PMC  EPMC
    35. 2006
  35. [YEAR:8-3-2006]Andreasen,D., Vuagniaux,G., Fowler-Jaeger,N., Hummler,E. and Rossier,B.C.<br>Activation of epithelial sodium channels by mouse channel activating proteases (mCAP) expressed in Xenopus oocytes requires catalytic activity of mCAP3 and mCAP2 but not mCAP1<br>J Am Soc Nephrol (8-3-2006) 17, 968-976. PubMed  Europe PubMed DOI
  36. Kleyman,T.R., Myerburg,M.M. and Hughey,R.P.<br>Regulation of ENaCs by proteases: an increasingly complex story<br>Kidney Int (2006) 70, 1391-1392. PubMed  Europe PubMed DOI
    37. 2005
  37. Kebebew,E., Peng,M., Reiff,E., Duh,Q.Y., Clark,O.H. and McMillan,A.<br>ECM1 and TMPRSS4 are diagnostic markers of malignant thyroid neoplasms and improve the accuracy of fine needle aspiration biopsy<br>Ann Surg (2005) 242, 353-361. PubMed  Europe PubMed DOI  PMC  EPMC
  38. Yamada,H., Shinmura,K., Tsuneyoshi,T. and Sugimura,H.<br>Effect of splice-site polymorphisms of the TMPRSS4, NPHP4 and ORCTL4 genes on their mRNA expression<br>J Genet (2005) 84, 131-136. PubMed  Europe PubMed  R
    39. 2004
  39. [YEAR:10-9-2004]Caldwell,R.A., Boucher,R.C. and Stutts,M.J.<br>Serine protease activation of near-silent epithelial Na+ channels<br>Am J Physiol Cell Physiol (10-9-2004) 286, C190-C194. PubMed  Europe PubMed DOI
    40. 2003
  40. Szabo,R., Wu,Q., Dickson,R.B., Netzel-Arnett,S., Antalis,T.M. and Bugge,T.H.<br>Type II transmembrane serine proteases<br>Thromb Haemost (2003) 90, 185-193. PubMed  Europe PubMed DOI  V
    41. 2002
  41. Vuagniaux,G., Vallet,V., Jaeger,N.F., Hummler,E. and Rossier,B.C.<br>Synergistic activation of ENaC by three membrane-bound channel-activating serine proteases (mCAP1, mCAP2, and mCAP3) and serum- and glucocorticoid-regulated kinase (Sgk1) in Xenopus oocytes<br>J Gen Physiol (2002) 120, 191-201. PubMed  Europe PubMed DOI  PMC  EPMC
    42. 2000
  42. [YEAR:15-5-2000]Wallrapp,C., Hahnel,S., Muller-Pillasch,F., Burghardt,B., Iwamura,T., Ruthenburger,M., Lerch,M.M., Adler,G. and Gress,T.M.<br>A novel transmembrane serine protease (TMPRSS3) overexpressed in pancreatic cancer<br>Cancer Res (15-5-2000) 60, 2602-2606. PubMed  Europe PubMed

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