Substrates for peptidase S01.020: kallikrein-related peptidase 12

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Kallikrein-1 precursor	P06870	19-262	peptide-Arg24+Ile-peptide	P	NT	Ile	Gln	Ser	Arg	Ile	Val	Gly	Gly	Yoon et al., 2007
Kallikrein-10 precursor	O43240	31-276	peptide-Arg42+Leu-peptide	P	NT	Asn	Asp	Thr	Arg	Leu	Asp	Pro	Glu	Yoon et al., 2007
Kallikrein-11 precursor	Q9UBX7	51-282	Glu-Thr-Arg53+Ile-peptide	P	NT	-	Glu	Thr	Arg	Ile	Ile	Lys	Gly	Yoon et al., 2007
Kallikrein-12 precursor	Q9UKR0	18-248	Ala-Thr-Pro-Lys21+Ile-peptide	P	NT	Ala	Thr	Pro	Lys	Ile	Phe	Asn	Gly	Yoon et al., 2007
Kallikrein-13 precursor	Q9UKR3	17-277	peptide-Lys25+Val-peptide	P	NT	Glu	Ser	Ser	Lys	Val	Leu	Asn	Thr	Yoon et al., 2007
Kallikrein-14 precursor	Q9P0G3	35-267	peptide-Lys40+Ile-peptide	P	NT	Asp	Glu	Asn	Lys	Ile	Ile	Gly	Gly	Yoon et al., 2007
Kallikrein-15 precursor	Q9H2R5	17-256	peptide-Lys21+Leu-peptide	P	NT	Asp	Gly	Asp	Lys	Leu	Leu	Glu	Gly	Yoon et al., 2007
Kallikrein-2 precursor	P20151	19-261	peptide-Arg24+Ile-peptide	P	NT	Ile	Gln	Ser	Arg	Ile	Val	Gly	Gly	Yoon et al., 2007
Kallikrein-5 precursor	Q9Y337	23-293	peptide-Arg66+Ile-peptide	P	NT	Ser	Ser	Ser	Arg	Ile	Ile	Asn	Gly	Yoon et al., 2007
Kallikrein-6 precursor	Q92876	17-244	peptide-Lys21+Leu-peptide	P	NT	Glu	Gln	Asn	Lys	Leu	Val	His	Gly	Yoon et al., 2007
Kallikrein-7 precursor	P49862	23-253	peptide-Lys29+Ile-peptide	P	NT	Gln	Gly	Asp	Lys	Ile	Ile	Asp	Gly	Yoon et al., 2007
Kallikrein-8 precursor	O60259	29-260	Gln-Glu-Asp-Lys32+Val-peptide	P	NT	Gln	Glu	Asp	Lys	Val	Leu	Gly	Gly	Yoon et al., 2007
Kallikrein-9 precursor	Q9UKQ9	16-250	peptide-Arg22+Ala-peptide	P	NT	Ala	Asp	Thr	Arg	Ala	Ile	Gly	Ala	Yoon et al., 2007
Prostate-specific antigen precursor	P07288	18-261	peptide-Arg24+Ile-peptide	P	NT	Ile	Leu	Ser	Arg	Ile	Val	Gly	Gly	Yoon et al., 2007
Protein CYR61	O00622	25-381	Peptide-Lys208+Arg-Peptide	P	NT	Ser	Ser	Leu	Lys	Arg	Leu	Pro	Val	Guillon-Munos et al., 2011
Protein CYR61	O00622	25-381	Peptide-Arg218+Ile-Peptide	P	NT	Met	Glu	Pro	Arg	Ile	Leu	Tyr	Asn	Guillon-Munos et al., 2011
Protein CYR61	O00622	25-381	Peptide-Lys290+Lys-Peptide	P	NT	Ser	Lys	Thr	Lys	Lys	Ser	Pro	Glu	Guillon-Munos et al., 2011
Protein CYR61	O00622	25-381	Peptide-Lys345+Asn-Peptide	P	NT	Thr	Phe	Ser	Lys	Asn	Val	Met	Met	Guillon-Munos et al., 2011
Protein CYR61	O00622	25-381	Peptide-Lys88+Gly-Peptide	P	NT	Thr	Ala	Leu	Lys	Gly	Ile	Cys	Arg	Guillon-Munos et al., 2011
WNT1-inducible-signaling pathway protein 2	O76076	24-250	Peptide-Arg215+Val-Peptide	P	NT	Met	Ala	Thr	Arg	Val	Ser	Asn	Gln	Guillon-Munos et al., 2011