Substrates for peptidase M54.001: archaelysin

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Angiotensin II	P01019	34-41	Asp-Arg-Val-Tyr37+Ile-His-Pro-Phe	P	NT	Asp	Arg	Val	Tyr	Ile	His	Pro	Phe	Cowan et al., 1987
Insulin B (oxidised)	P01308	25-54	Peptide+Ala38+Leu-Peptide	N	NT	Leu	Val	Glu	Ala	Leu	Tyr	Leu	Val	Cowan et al., 1987
Insulin B (oxidised)	P01308	25-54	Peptide-Leu39+Tyr-Peptide	N	NT	Val	Glu	Ala	Leu	Tyr	Leu	Val	Cya	Cowan et al., 1987
Serum thymic factor	P01255	1-9	Glu-Ala-Lys-Ser4+Gln-Gly-Gly-Ser-Asn	P	NT	Glu	Ala	Lys	Ser	Gln	Gly	Gly	Ser	Cowan et al., 1987