Substrates for peptidase M32.003: TcMCP1 carboxypeptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
(desArg)-bradykinin	P01042	381-388	Arg-Pro-Pro-Gly-Phe-Ser-Pro+Phe	N	Gly	Phe	Ser	Pro	Phe	'-'	'-'	'-'	Frasch et al., 2012
Abz-Arg-Arg-Phe-Phe-Lys(Dnp)-OH			Abz-Arg-ArgPhe-Phe+Lys(Dnp)-OH	S	Arg	Arg	Phe	Phe	Lyd	-	-	-	Frasch et al., 2018
Abz-Arg-Arg-Phe-Phe-Lys(Dnp)-OH			Abz-Arg-ArgPhe-Phe+Lys(Dnp)-OH	S	Arg	Arg	Phe	Phe	Lyd	-	-	-	Frasch et al., 2018
Abz-Arg-Phe-Phe-Lys(Dnp)-OH			Abz-Arg-Phe-Phe+Lys(Dnp)-OH	S	Abz	Arg	Phe	Phe	Lyd	-	-	-	Frasch et al., 2018
Abz-Arg-Phe-Phe-Lys(Dnp)-OH			Abz-Arg-Phe-Phe+Lys(Dnp)-OH	S	Abz	Arg	Phe	Phe	Lyd	-	-	-	Frasch et al., 2018
Abz-Leu-Leu-Lys-Phe-Lys(Dnp)-OH			Abz-Leu-Leu-Lys-Phe+Lys(Dnp)-OH	S	Leu	Leu	Lys	Phe	Lyd	-	-	-	Frasch et al., 2018
Abz-Leu-Leu-Lys-Phe-Lys(Dnp)-OH			Abz-Leu-Leu-Lys-Phe+Lys(Dnp)-OH	S	Leu	Leu	Lys	Phe	Lyd	-	-	-	Frasch et al., 2018
Abz-Leu-Lys-Phe-Lys(Dnp)-OH			Abz-Leu-Lys-Phe+Lys(Dnp)-OH	S	Abz	Leu	Lys	Phe	Lyd	-	-	-	Frasch et al., 2018
Abz-Leu-Lys-Phe-Lys(Dnp)-OH			Abz-Leu-Lys-Phe+Lys(Dnp)-OH	S	Abz	Leu	Lys	Phe	Lyd	-	-	-	Frasch et al., 2018
Abz-Lys-Phe-Lys(Dnp)-OH			Abz-Lys-Phe+Lys(Dnp)-OH	S	-	Abz	Lys	Phe	Lyd	-	-	-	Frasch et al., 2018
Abz-Lys-Phe-Lys(Dnp)-OH			Abz-Lys-Phe+Lys(Dnp)-OH	S	-	Abz	Lys	Phe	Lyd	-	-	-	Frasch et al., 2018
Abz-Phe-Arg-Lys(Dnp)-OH			Abz-Phe-Arg+Lys(Dnp)-OH	S	-	Abz	Phe	Arg	Lyd	-	-	-	Frasch et al., 2012
Abz-Phe-His-Lys(Dnp)-OH			Abz-Phe-His+Lys(Dnp)-OH	S	-	Abz	Phe	His	Lyd	-	-	-	Frasch et al., 2012
Abz-Phe-Phe-Lys(Dnp)-OH			Abz-Phe-Phe+Lys(Dnp)-OH	S	-	Abz	Phe	Phe	Lyd	-	-	-	Frasch et al., 2018
Abz-Phe-Phe-Lys(Dnp)-OH			Abz-Phe-Phe+Lys(Dnp)-OH	S	-	Abz	Phe	Phe	Lyd	-	-	-	Frasch et al., 2018
Abz-Phe-Val-Lys(Dnp)-OH			Abz-Phe-Val+Lys(Dnp)-OH	S	-	Abz	Phe	Val	Lyd	-	-	-	Frasch et al., 2012
Ala-Ser-Gly-Lys-Ala-Ser-Gly-Lys-Ala-Ser-Gly-Lys-Dpa-Ala-Ala-Trp			Ala-Ser-Gly-Lys-Ala-Ser-Gly-Lys-Ala-Ser-Gly-Lys-Dpa-Ala-Ala+Trp	S	Lys	Dpa	Ala	Ala	Trp	-	-	-	Isaza et al., 2008
Ala-Ser-Gly-Lys-Ala-Ser-Gly-Lys-Dpa-Ala-Ala-Trp			Ala-Ser-Gly-Lys-Ala-Ser-Gly-Lys-Dpa-Ala-Ala+Trp	S	Lys	Dpa	Ala	Ala	Trp	-	-	-	Isaza et al., 2008
Ala-Ser-Gly-Lys-Dpa-Ala-Ala-Trp			Ala-Ser-Gly-Lys-Dpa-Ala-Ala+Trp	S	Lys	Dpa	Ala	Ala	Trp	-	-	-	Isaza et al., 2008
angiotensin I	P01019	34-43	Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His+Leu	N	His	Pro	Phe	His	Leu	'-'	'-'	'-'	Frasch et al., 2012
angiotensin I	P01019	34-43	Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His+Leu	N	His	Pro	Phe	His	Leu	'-'	'-'	'-'	Frasch et al., 2012
angiotensin(1-9)	P01019	34-43	Asp-Arg-Val-Tyr-Ile-His-Pro-Phe+His	N	Ile	His	Pro	Phe	His	'-'	'-'	'-'	Frasch et al., 2012
angiotensin(1-9)	P01019	34-43	Asp-Arg-Val-Tyr-Ile-His-Pro-Phe+His	N	Ile	His	Pro	Phe	His	'-'	'-'	'-'	Frasch et al., 2012
angiotensin-2	P01019	34-43	Asp-Arg-Val-Tyr-Ile-His-Pro+Phe	N	Tyr	Ile	His	Pro	Phe	'-'	'-'	'-'	Frasch et al., 2012
bradykinin	P01042	381-389	Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe+Arg	N	Phe	Ser	Pro	Phe	Arg	'-'	'-'	'-'	Frasch et al., 2012
bradykinin	P01042	381-389	Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe+Arg	N	Phe	Ser	Pro	Phe	Arg	'-'	'-'	'-'	Frasch et al., 2012
furylacryloyl-Ala-Lys (FAAK)			furylacryloyl-Ala+Lys	S	-	-	FA	Ala	Lys	-	-	-	Niemirowicz et al., 2007