Substrates for peptidase M28.010: glutamate carboxypeptidase II

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Ac-Ala-Glu Ac-Ala+Glu S - - Ac Ala Glu - - - Carter & Coyle, 2004
Ac-Ala-Met Ac-Ala+Met S - - Ac Ala Met - - - Carter & Coyle, 2004
Ac-Asp-Glu Ac-Asp+Glu P - - Ac Asp Glu - - - Carter & Coyle, 2004
Ac-Glu-Glu Ac-Glu+Glu S - - Ac Glu Glu - - - Hlouchova et al., 2007
Ac-Glu-Met Ac-Glu+Met S - - Ac Glu Met - - - Carter & Coyle, 2004
Asp-Glu Asp+Glu N - - - Asp Glu - - - Carter & Coyle, 2004
beta-ac-Asp-Glu beta-ac-Asp+Glu N - - Ac Asp Glu - - - Hlouchova et al., 2007
gamma-Glu-Glu gamma-Glu+Glu N - - - Glu Glu - - - Carter & Coyle, 2004
Glu-Glu Glu+Glu N - - - Glu Glu - - - Carter & Coyle, 2004
pteroylpolyglutamate pteroyl-Glu+Glu N - - Pte Glu Glu - - - Chandler et al., 1986