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Peptidase

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MEROPS SUBMISSIONS

Other
information

Sequence features for peptidase M28.010: glutamate carboxypeptidase II

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

 

MERNUM Species Sequence length Peptidase unit Active site residues Metal ligands Source
MER0689561 Acanthisitta chloris 442 1-268 D71, E116 H69, D79, E117, D145, H245 GENBANK:XP_009081672
MER0195496 Ailuropoda melanoleuca 751 292-577 D380, E425 H378, D388, E426, D454, H554 GENBANK:XP_002927890
MER0289444 Alligator mississippiensis 442 1-268 D71, E116 H69, D79, E117, D145, H245 GENBANK:XP_006260455
MER0307737 Alligator sinensis 622 235-469 D323, E368 H321, D331, E369, D397, H464 GENBANK:XP_006021111
MER0307742 Alligator sinensis 502 47-328 D131, E176 H129, D139, E177, D205, H305 GENBANK:XP_006021112
MER0336649 Anas platyrhynchos 731 273-557 D360, E405 H358, D368, E406, D434, H534 GENBANK:XP_005029631
MER0685367 Apaloderma vittatum 711 253-537 D340, E385 H338, D348, E386, D414, H514 GENBANK:XP_009876404
MER0685569 Aptenodytes forsteri 743 285-569 D372, E417 H370, D380, E418, D446, H546 GENBANK:XP_009284557
MER0685247 Aquila chrysaetos 750 292-576 D379, E424 H377, D387, E425, D453, H553 GENBANK:XP_011584638
MER0556048 Astatotilapia burtoni 737 279-558 D366, E411 H364, D374, E412, D440, H540 GENBANK:XP_005942852
MER0401609 Balaenoptera acutorostrata 442 1-268 D71, E116 H69, D79, E117, D145, H245 GENBANK:XP_007188972
MER0682227 Balearica regulorum 711 253-537 D340, E385 H338, D348, E386, D414, H514 GENBANK:XP_010298405
MER0679009 Bison bison 750 291-576 D379, E424 H377, D387, E425, D453, H553 GENBANK:XP_010852915
MER0077532 Bos grunniens 729 270-555 D358, E403 H356, D366, E404, D432, H532 UNIPROT:L8II65
MER0077532 Bos grunniens 729 270-555 D358, E403 H356, D366, E404, D432, H532 UNIPROT:L8II65
MER0107981 Bos taurus 750 292-576 D379, E424 H377, D387, E425, D453, H553 UNIPROT:A6QLT8
MER0107981 Bos taurus 750 292-576 D379, E424 H377, D387, E425, D453, H553 UNIPROT:A6QLT8
MER0581164 Bubalus bubalis 750 291-576 D379, E424 H377, D387, E425, D453, H553 GENBANK:XP_006075236
MER0678645 Buceros rhinoceros 711 253-537 D340, E385 H338, D348, E386, D414, H514 GENBANK:XP_010137895
MER0195490 Callithrix jacchus 750 291-576 D379, E424 H377, D387, E425, D453, H553 UNIPROT:F6TR32
MER0195490 Callithrix jacchus 750 291-576 D379, E424 H377, D387, E425, D453, H553 UNIPROT:F6TR32
MER0196093 Callithrix jacchus 202 1-28 missing, missing missing, missing, missing, missing, H5 UNIPROT:A6MLF7
MER0196093 Callithrix jacchus 202 1-28 missing, missing missing, missing, missing, missing, H5 UNIPROT:A6MLF7
MER0581810 Calypte anna 740 282-566 D369, E414 H367, D377, E415, D443, H543 GENBANK:XP_008498762
MER0676742 Camelus dromedarius 751 292-577 D380, E425 H378, D388, E426, D454, H554 GENBANK:XP_010977770
MER0512623 Camelus ferus 802 343-628 D431, E476 H429, D439, E477, D505, H605 GENBANK:XP_006192466
MER0053597 Canis lupus familiaris 838 379-664 D467, E512 H465, D475, E513, D541, H641 GENBANK:XP_533980
MER0521877 Capra hircus 868 409-694 D497, E542 H495, D505, E543, D571, H671 GENBANK:XP_005699518
MER0676033 Cariama cristata 711 253-537 D340, E385 H338, D348, E386, D414, H514 GENBANK:XP_009707781
MER0103480 Cavia porcellus 751 293-577 D380, E425 H378, D388, E426, D454, H554 GENBANK:XP_003468648
MER0405866 Ceratotherium simum 759 413-678 D501, E546 H499, D509, E547, D575, M675 GENBANK:XP_004434217
MER0584549 Cercopithecus sabaeus 750 291-576 D379, E424 H377, D387, E425, D453, H553 GENBANK:XP_008018658
MER0673325 Chaetura pelagica 729 271-555 D358, E403 H356, D366, E404, D432, H532 GENBANK:XP_010000924
MER0671909 Charadrius vociferus 738 280-564 D367, E412 H365, D375, E413, D441, H541 GENBANK:XP_009879546
MER0591284 Chelonia mydas 689 231-515 D318, E363 H316, D326, E364, D392, H492 GENBANK:XP_007063188
MER0584237 Chinchilla lanigera 694 235-520 D323, E368 H321, D331, E369, D397, H497 GENBANK:XP_005379782
MER0576830 Chrysemys picta 750 292-576 D379, E424 H377, D387, E425, D453, H553 GENBANK:XP_005304120
MER0575580 Chrysochloris asiatica 750 291-576 D379, E424 H377, D387, E425, D453, H553 GENBANK:XP_006871272
MER0575582 Chrysochloris asiatica 442 1-268 D71, E116 H69, D79, E117, D145, H245 GENBANK:XP_006871274
MER0671349 Colius striatus 764 306-590 D393, E438 H391, D401, E439, D467, H567 GENBANK:XP_010195944
MER0669194 Colobus angolensis 750 291-576 D379, E424 H377, D387, E425, D453, H553 GENBANK:XP_011793853
MER0669198 Colobus angolensis 442 1-268 D71, E116 H69, D79, E117, D145, H245 GENBANK:XP_011793857
MER0077556 Columba livia 712 254-538 D341, E386 H339, D349, E387, D415, H515 GENBANK:EMC80338
MER0572831 Corvus brachyrhynchos 781 323-607 D410, E455 H408, D418, E456, D484, H584 GENBANK:XP_008633195
MER0668378 Corvus cornix 751 293-577 D380, E425 H378, D388, E426, D454, H554 GENBANK:XP_010399382
MER0195512 Cricetulus griseus 751 293-577 D380, E425 H378, D388, E426, D454, H554 GENBANK:XP_003514884
MER0665641 Cuculus canorus 752 294-578 D381, E426 H379, D389, E427, D455, H555 GENBANK:XP_009564795
MER0102782 Dasypus novemcinctus 750 291-576 D379, E424 H377, D387, E425, D453, H553 GENBANK:XP_004475841
MER0599405 Echinops telfairi 718 290-575 D378, E423 H376, D386, E424, D452, H552 GENBANK:XP_004709014
MER0664184 Egretta garzetta 852 394-678 D481, E526 H479, D489, E527, D555, H655 GENBANK:XP_009639983
MER0564261 Eptesicus fuscus 751 292-577 D380, E425 H378, D388, E426, D454, H554 GENBANK:XP_008151831
MER0564263 Eptesicus fuscus 442 1-268 D71, E116 H69, D79, E117, D145, H245 GENBANK:XP_008151833
MER0098301 Equus caballus 751 292-577 D380, E425 H378, D388, E426, D454, H554 UNIPROT:F6TC16
MER0098301 Equus caballus 751 292-577 D380, E425 H378, D388, E426, D454, H554 UNIPROT:F6TC16
MER0658459 Eurypyga helias 441 253-441 D340, E385 H338, D348, E386, D414, missing GENBANK:XP_010146402
MER0658587 Eurypyga helias 270 1-96 missing, missing missing, missing, missing, missing, H73 GENBANK:XP_010149173
MER0559934 Falco cherrug 747 289-573 D376, E421 H374, D384, E422, D450, H550 GENBANK:XP_005434766
MER0545548 Falco peregrinus 724 266-550 D353, E398 H351, D361, E399, D427, H527 GENBANK:XP_005232275
MER0225108 Felis catus 720 292-577 D380, E425 H378, D388, E426, D454, H554 GENBANK:XP_003992686
MER1129094 Felis catus 651 292-577 D380, E425, H378, D388, E426, D454, H554, UNIPROT:M3W898
MER0568508 Ficedula albicollis 751 293-577 D380, E425 H378, D388, E426, D454, H554 UNIPROT:U3JZM4
MER0568508 Ficedula albicollis 751 293-577 D380, E425 H378, D388, E426, D454, H554 UNIPROT:U3JZM4
MER0655316 Fukomys damarensis 722 263-548 D351, E396 H349, D359, E397, D425, H525 GENBANK:XP_010632083
MER0654436 Fulmarus glacialis 710 252-536 D339, E384 H337, D347, E385, D413, H513 GENBANK:XP_009586005
MER0549372 Galeopterus variegatus 126 1-113 D10, E55 H8, D18, E56, D84, missing GENBANK:XP_008562231
MER0557493 Galeopterus variegatus 245 37-71 missing, missing missing, missing, missing, missing, H48 GENBANK:XP_008590502
MER0113444 Gallus gallus 760 301-586 Y101, D389, S152, E434 H387, N99, D397, W110, L153, E435, E201, D463, P283, H563 UNIPROT:E1C7K6
MER0113444 Gallus gallus 760 301-586 Y101, D389, S152, E434 H387, N99, D397, W110, L153, E435, E201, D463, P283, H563 UNIPROT:E1C7K6
MER0653707 Gavia stellata 442 1-268 D71, E116 H69, D79, E117, D145, H245 GENBANK:XP_009819691
MER0559217 Geospiza fortis 783 325-609 D412, E457 H410, D420, E458, D486, H586 GENBANK:XP_005417879
MER0225067 Gorilla gorilla 656 291-576 D379, E424 H377, D387, E425, D453, H553 GENBANK:XP_004051136
MER0653102 Haliaeetus albicilla 719 261-545 D348, E393 H346, D356, E394, D422, H522 GENBANK:XP_009916786
MER0652181 Haliaeetus leucocephalus 750 292-576 D379, E424 H377, D387, E425, D453, H553 GENBANK:XP_010576548
MER0195504 Heterocephalus glaber 442 1-268 D71, E116 H69, D79, E117, D145, H245 UNIPROT:G5BHD1
MER0195504 Heterocephalus glaber 442 1-268 D71, E116 H69, D79, E117, D145, H245 UNIPROT:G5BHD1
MER0002104 Homo sapiens 750 291-576 D379, E424 H377, D387, E425, D453, H553 UNIPROT:Q7Z5D2
MER0002104 Homo sapiens 750 291-576 D379, E424 H377, D387, E425, D453, H553 UNIPROT:Q7Z5D2
MER0002104 Homo sapiens 750 291-576 D379, E424 H377, D387, E425, D453, H553 UNIPROT:Q7Z5D2
MER0002104 Homo sapiens 750 291-576 D379, E424 H377, D387, E425, D453, H553 UNIPROT:Q7Z5D2
MER0002104 Homo sapiens 750 291-576 D379, E424 H377, D387, E425, D453, H553 UNIPROT:Q7Z5D2
MER0612664 Ictidomys tridecemlineatus 698 292-498 D380, S415 H378, D388, Y416, D444, missing GENBANK:XP_005339267
MER0548455 Jaculus jaculus 749 290-575 D378, E423 H376, D386, E424, D452, H552 GENBANK:XP_004658312
MER0548457 Jaculus jaculus 442 1-268 D71, E116 H69, D79, E117, D145, H245 GENBANK:XP_004658314
MER0552298 Leptonychotes weddellii 751 292-577 D380, E425 H378, D388, E426, D454, H554 GENBANK:XP_006727431
MER0552300 Leptonychotes weddellii 442 1-268 D71, E116 H69, D79, E117, D145, H245 GENBANK:XP_006727433
MER0549013 Lipotes vexillifer 750 291-576 D379, E424 H377, D387, E425, D453, H553 GENBANK:XP_007457413
MER0549015 Lipotes vexillifer 442 1-268 D71, E116 H69, D79, E117, D145, H245 GENBANK:XP_007457415
MER0195484 Macaca fascicularis 750 291-576 D379, E424 H377, D387, E425, D453, H553 UNIPROT:G7PNF1
MER0195484 Macaca fascicularis 750 291-576 D379, E424 H377, D387, E425, D453, H553 UNIPROT:G7PNF1
MER0320884 Macaca fascicularis 322 291-317 missing, missing missing, missing, missing, missing, missing UNIPROT:I7GEN6
MER0320884 Macaca fascicularis 322 291-317 missing, missing missing, missing, missing, missing, missing UNIPROT:I7GEN6
MER0113402 Macaca mulatta 800 341-626 Q141, D429, S192, E474 N139, H427, D437, W150, E475, L193, D503, D241, H603, P323 GENBANK:XP_001096141
MER0647190 Manacus vitellinus 729 271-555 D358, E403 H356, D366, E404, D432, H532 GENBANK:XP_008931632
MER0645648 Mandrillus leucophaeus 753 291-579 D379, E427 N377, L388, E428, D456, H556 GENBANK:XP_011840282
MER0541980 Maylandia zebra 737 280-558 D366, E411 H364, D374, E412, D440, H540 GENBANK:XP_004543944
MER0195549 Meleagris gallopavo 396 56-222 missing, E70 missing, missing, E71, D99, H199 GENBANK:XP_003203574
MER0195712 Meleagris gallopavo 481 275-397 D362, missing H360, D370, missing, missing, missing GENBANK:XP_003203577
MER0540997 Melopsittacus undulatus 743 285-569 D372, E417 H370, D380, E418, D446, H546 GENBANK:XP_005149848
MER0640780 Merops nubicus 728 270-554 D357, E402 H355, D365, E403, D431, H531 GENBANK:XP_008942434
MER0538376 Microtus ochrogaster 753 293-579 D381, E427 H379, D389, E428, D456, H556 GENBANK:XP_005357668
MER0113435 Monodelphis domestica 724 266-550 D65, D353, E398, S116 H351, N63, D361, W74, E399, L117, D427, D165, P247, H527 GENBANK:XP_001362668
MER0005150 Mus musculus 752 293-578 D381, E426 H379, D389, E427, D455, H555 UNIPROT:O35409
MER0005150 Mus musculus 752 293-578 D381, E426 H379, D389, E427, D455, H555 UNIPROT:O35409
MER0005150 Mus musculus 752 293-578 D381, E426 H379, D389, E427, D455, H555 UNIPROT:O35409
MER0195500 Mustela putorius 518 59-344 D147, E192 H145, D155, E193, D221, H321 UNIPROT:M1ERQ2
MER0195500 Mustela putorius 518 59-344 D147, E192 H145, D155, E193, D221, H321 UNIPROT:M1ERQ2
MER0571070 Myotis brandtii 694 235-520 D323, E368 H321, D331, E369, D397, H497 GENBANK:XP_005879400
MER0225169 Myotis davidii 694 235-520 D323, E368 H321, D331, E369, D397, H497 GENBANK:ELK33219
MER0102003 Myotis lucifugus 751 292-577 D380, E425 H378, D388, E426, D454, H554 GENBANK:XP_006092934
MER0641583 Nannospalax galili 755 293-578 D381, E426 H379, D389, E427, D455, H555 GENBANK:XP_008851841
MER0535123 Neolamprologus brichardi 737 279-558 D366, E411 H364, D374, E412, D440, H540 GENBANK:XP_006802159
MER0638133 Nestor notabilis 725 267-551 D354, E399 H352, D362, E400, D428, H528 GENBANK:XP_010016962
MER0636567 Nipponia nippon 733 275-559 D362, E407 H360, D370, E408, D436, H536 GENBANK:XP_009468688
MER0195477 Nomascus leucogenys 750 291-576 D379, E424 H377, D387, E425, D453, H553 UNIPROT:G1S1J6
MER0195477 Nomascus leucogenys 750 291-576 D379, E424 H377, D387, E425, D453, H553 UNIPROT:G1S1J6
MER0635132 Notothenia coriiceps 329 282-329 missing, missing missing, missing, missing, missing, missing GENBANK:XP_010768990
MER0534296 Ochotona princeps 731 280-557 D360, E405 H358, D368, E406, D434, H534 GENBANK:XP_004590071
MER0532199 Octodon degus 920 464-746 D551, E596 H549, D559, E597, D625, H723 GENBANK:XP_004647498
MER0530467 Odobenus rosmarus 281 1-107 missing, missing missing, missing, missing, missing, H84 GENBANK:XP_004417522
MER0530480 Odobenus rosmarus 181 15-181 D103, E148 H101, D111, E149, D177, missing GENBANK:XP_004417692
MER0634343 Opisthocomus hoazin 743 285-569 D372, E417 H370, D380, E418, D446, H546 GENBANK:XP_009930890
MER0097846 Ornithorhynchus anatinus 925 466-751 D554, E599 H552, D562, E600, D628, H728 GENBANK:XP_001512294
MER0619849 Ornithorhynchus anatinus 692 294-518 D382, E427 H380, D390, E428, D456, H495 GENBANK:XP_007666300
MER0527799 Orycteropus afer 714 255-540 D343, L388 H341, D351, L389, D417, H517 GENBANK:XP_007936278
MER0195514 Oryctolagus cuniculus 720 277-546 D349, E394 H347, D357, E395, D423, H523 GENBANK:XP_002708512
MER0320606 Otolemur garnettii 751 292-577 D380, E425 H378, D388, E426, D454, H554 GENBANK:XP_003780880
MER0225166 Ovis aries 750 291-576 D379, E424 H377, D387, E425, D453, H553 GENBANK:XP_004019438
MER0320746 Pan paniscus 319 238-317 missing, missing missing, missing, missing, missing, missing GENBANK:XP_003804433
MER0320766 Pan paniscus 145 1-65 missing, missing missing, missing, missing, missing, H42 GENBANK:XP_003804531
MER0320773 Pan paniscus 65 1-65 D36, missing H34, D44, missing, missing, missing GENBANK:XP_003804173
MER0053255 Pan troglodytes 750 291-576 D379, E424 H377, D387, E425, D453, H553 UNIPROT:H2Q3K5
MER0053255 Pan troglodytes 750 291-576 D379, E424 H377, D387, E425, D453, H553 UNIPROT:H2Q3K5
MER0195501 Pan troglodytes 442 1-268 D71, E116 H69, D79, E117, D145, H245 GENBANK:XP_003313062
MER0519267 Panthera tigris 671 212-497 D300, E345 H298, D308, E346, D374, H474 GENBANK:XP_007079067
MER0517277 Pantholops hodgsonii 468 9-294 D97, E142 H95, D105, E143, D171, H271 GENBANK:XP_005970137
MER0230907 Papio anubis 50 1-45 missing, missing missing, missing, missing, D17, missing GENBANK:XP_003918954
MER0230923 Papio anubis 209 1-35 missing, missing missing, missing, missing, missing, H12 GENBANK:XP_003910578
MER0632922 Pelecanus crispus 456 92-376 D179, E224 H177, D187, E225, D253, H353 GENBANK:XP_009479032
MER0632218 Phaethon lepturus 440 1-268 D71, E116 H69, D79, E117, D145, H245 GENBANK:XP_010292494
MER0631219 Phalacrocorax carbo 711 253-537 D340, E385 H338, D348, E386, D414, H514 GENBANK:XP_009505553
MER0520088 Physeter catodon 559 100-385 D188, E233 H186, D196, E234, D262, H362 GENBANK:XP_007123453
MER0629768 Picoides pubescens 721 265-547 D350, E395 H348, D358, E396, D424, H524 GENBANK:XP_009899819
MER0523954 Poecilia formosa 751 293-577 D380, E425 H378, D388, E426, D454, H554 UNIPROT:K7GIC0
MER0523954 Poecilia formosa 751 293-577 D380, E425 H378, D388, E426, D454, H554 UNIPROT:K7GIC0
MER0523955 Poecilia formosa 679 293-511 D380, E425 H378, D388, E426, D454, missing GENBANK:XP_006118443
MER0195487 Pongo abelii 800 341-626 D429, E474 H427, D437, E475, D503, H603 GENBANK:XP_002822384
MER0591124 Pterocles gutturalis 594 231-514 D317, E362 H315, D325, E363, D391, H491 GENBANK:XP_010075866
MER0225386 Pteropus alecto 748 289-574 D377, E422 H375, D385, E423, D451, H551 UNIPROT:L5JNE0
MER0225386 Pteropus alecto 748 289-574 D377, E422 H375, D385, E423, D451, H551 UNIPROT:L5JNE0
MER0442980 Python bivittatus 754 295-580 D383, E428 H381, D391, E429, D457, H557 GENBANK:XP_007435712
MER0002634 Rattus norvegicus 752 293-578 D381, E426 H379, D389, E427, D455, H555 UNIPROT:P70627
MER0002634 Rattus norvegicus 752 293-578 D381, E426 H379, D389, E427, D455, H555 UNIPROT:P70627
MER0002634 Rattus norvegicus 752 293-578 D381, E426 H379, D389, E427, D455, H555 UNIPROT:P70627
MER0570373 Rhinopithecus roxellana 750 291-576 D379, E424 H377, D387, E425, D453, H553 GENBANK:XP_010382620
MER0570391 Rhinopithecus roxellana 442 1-268 D71, E116 H69, D79, E117, D145, H245 GENBANK:XP_010382624
MER0225093 Saimiri boliviensis 750 291-576 D379, E424 H377, D387, E425, D453, H553 GENBANK:XP_003935134
MER0320613 Sarcophilus harrisii 788 353-617 D440, E485 H438, D448, E486, D514, H594 GENBANK:XP_003766564
MER0549738 Serinus canaria 751 293-577 D380, E425 H378, D388, E426, D454, H554 GENBANK:XP_009100989
MER0515684 Struthio camelus 442 1-268 D71, E116 H69, D79, E117, D145, H245 GENBANK:XP_009687396
MER0004488 Sus scrofa 751 292-577 D380, E425 H378, D388, E426, D454, H554 UNIPROT:O77564
MER0004488 Sus scrofa 751 292-577 D380, E425 H378, D388, E426, D454, H554 UNIPROT:O77564
MER0004488 Sus scrofa 751 292-577 D380, E425 H378, D388, E426, D454, H554 UNIPROT:O77564
MER0190347 Taeniopygia guttata 751 292-577 D380, E425 H378, D388, E426, D454, H554 GENBANK:XP_002188120
MER0596111 Tarsius syrichta 751 292-577 D380, E425 H378, D388, E426, D454, H554 GENBANK:XP_008067077
MER0332973 Tauraco erythrolophus 270 1-96 missing, missing missing, missing, missing, missing, H73 UNIPROT:A0A093E0I8
MER0332973 Tauraco erythrolophus 270 1-96 missing, missing missing, missing, missing, missing, H73 UNIPROT:A0A093E0I8
MER0398289 Tauraco erythrolophus 309 121-309 D208, E253 H206, D216, E254, D282, missing GENBANK:XP_009980582
MER0480798 Tinamus guttatus 442 1-268 D71, E116 H69, D79, E117, D145, H245 GENBANK:XP_010219829
MER0489051 Trichechus manatus 750 291-576 D379, E424 H377, D387, E425, D453, H553 GENBANK:XP_004390536
MER0489055 Trichechus manatus 442 1-268 D71, E116 H69, D79, E117, D145, H245 GENBANK:XP_004390539
MER0082153 Tupaia chinensis 751 292-577 D380, E425 H378, D388, E426, D454, H554 GENBANK:XP_006160397
MER0622470 Tursiops truncatus 442 1-268 D71, E116 H69, D79, E117, D145, H245 GENBANK:XP_004320399
MER0453896 Tyto alba 711 253-537 D340, E385 H338, D348, E386, D414, H514 GENBANK:XP_009960625
MER0135827 Ursus maritimus 748 289-574 D377, E422 H375, D385, E423, D451, H551 GENBANK:XP_008702660
MER0260452 Vicugna pacos 769 344-595 D398, E443 H396, D406, E444, D472, H572 GENBANK:XP_006218437
MER0195547 Xenopus tropicalis 753 295-579 D382, E427 H380, D390, E428, D456, H556 GENBANK:XP_002936599
MER0445280 Zonotrichia albicollis 882 424-708 D511, E556 H509, D519, E557, D585, H685 GENBANK:XP_005485883

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