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Literature for peptidase M28.010: glutamate carboxypeptidase II

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, R Splicing, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Cao,J., Sun,Z., Zhou,Z., Huang,Y., Peng,D., Jiang,X. and Chen,Y.
    Preliminary clinical study of p-iodo benzoyl moiety-modified PSMA inhibitors and prospective comparison with 68Ga-PSMA-11
    Sci Rep15, 20000-20000. PubMed  Europe PubMed DOI  I
  2. Li,W., Luo,Y., Hua,Y., Shen,Q., Chen,L., Xu,Y., Fu,H. and Yu,C.
    Preclinical Evaluation of a Novel PSMA-Targeted Agent (68)Ga-NOTA-GC-PSMA for Prostate Cancer Imaging
    Tomography11, PubMed  Europe PubMed DOI
  3. Meng,X., Hu,X., Gao,S., Jia,W., Zhang,S., Zhang,S., Wang,X., Ma,S. and Qin,C.
    PSMA-Guided PROTAC Degraders for Tumor-Specific Protein Degradation in Prostate Cancer
    J Med Chem PubMed  Europe PubMed DOI
  4. Mesbahi,N., Yoon,H., Fulton,M.D. and Berkman,C.E.
    A small-molecule pretargeting approach for PSMA-targeted conjugates
    Bioorg Med Chem Lett122, 130213-130213. PubMed  Europe PubMed DOI
  5. Ninatti,G., Scilipoti,P., Pini,C., Barletta,F., Longoni,M., Gelardi,F., Sollini,M., Gandaglia,G., Sathekge,M., Montorsi,F., Chiti,A. and Briganti,A.
    Time for action: actinium-225 PSMA-targeted alpha therapy for metastatic prostate cancer - a systematic review and meta-analysis
    Theranostics15, 3386-3399. PubMed  Europe PubMed DOI
  6. Zhang,X., Ma,L., Cai,K., Guo,X., Zhang,G., Dong,J., Zheng,Y., Su,X., Tao,T., Li,X. and Yuan,Y.
    PSMA-Targeted Intracellular Self-Assembled Probe for Enhanced PET Imaging
    Bioconjug Chem36, 20-24. PubMed  Europe PubMed DOI
    7. 2024
  7. Abdulmajeed,A.Z. and Nazhan,W.
    Kinetic Properties of Glutamate Carboxypeptidase II Partially Purified from Leukodystrophy Patient's Serum
    ACS Chem Neurosci15, 3384-3390. PubMed  Europe PubMed DOI
  8. Adekiya,T.A., Hudson,T., Bakare,O., Ameyaw,E.E., Adebayo,A., Olajubutu,O. and Adesina,S.K.
    PSMA-targeted combination brusatol and docetaxel nanotherapeutics for the treatment of prostate cancer
    Biomed Pharmacother177, 117125-117125. PubMed  Europe PubMed DOI
  9. Dai,R., Cai,Z., Hu,R., Huang,Y., Fu,L., Yang,J., Hu,K. and Li,H.
    (177)Lu-Labeled Bivalent Ligands of Prostate-Specific Membrane Antigen for Endoradiotherapy of Prostate Cancer
    Mol Pharm21, 883-894. PubMed  Europe PubMed DOI
  10. Dhull,A., Wei,J., Pulukuri,A.J., Rani,A., Sharma,R., Mesbahi,N., Yoon,H., Savoy,E.A., Xaivong Vi,S., Goody,K.J., Berkman,C.E., Wu,B.J. and Sharma,A.
    PSMA-targeted dendrimer as an efficient anticancer drug delivery vehicle for prostate cancer
    Nanoscale16, 5634-5652. PubMed  Europe PubMed DOI
  11. Hoxie,N., Qiu,Y., Kales,S.C., Schneider,R., Hu,X., Dalal,A., Ford-Scheimer,S.L., Wiseman,R., Tsukamoto,T., Wei,H., Slusher,B.S., Janiszewski,J.S. and Hall,M.D.
    Development of a high-throughput dual-stream liquid chromatography-tandem mass spectrometry method to screen for inhibitors of glutamate carboxypeptidase II
    Rapid Commun Mass Spectrome9772-e9772. PubMed  Europe PubMed DOI  V
  12. Ismuha,R.R., Ritawidya,R., Daruwati,I. and Muchtaridi,M.
    Future Prospect of Low-Molecular-Weight Prostate-Specific Membrane Antigen Radioisotopes Labeled as Theranostic Agents for Metastatic Castration-Resistant Prostate Cancer
    Molecules29, PubMed  Europe PubMed DOI  V
  13. Jiang,Z., Kadeerhan,G., Zhang,J., Guo,W., Guo,H. and Wang,D.
    Advances in prostate-specific membrane antigen-targeted theranostics: from radionuclides to near-infrared fluorescence technology
    Front Immunol15, 1533532-1533532. PubMed  Europe PubMed DOI  V
  14. Maes,J., Gesquiere,S., De Spiegeleer,A., Maes,A. and Van de Wiele,C.
    Prostate-Specific Membrane Antigen Biology and Pathophysiology in Prostate Carcinoma, an Update: Potential Implications for Targeted Imaging and Therapy
    Int J Mol Sci25, PubMed  Europe PubMed DOI  V
  15. Oldan,J.D., Almaguel,F., Voter,A.F., Duran,A., Gafita,A., Pomper,M.G., Hope,T.A. and Rowe,S.P.
    PSMA-Targeted Radiopharmaceuticals for Prostate Cancer Diagnosis and Therapy
    Cancer J30, 176-184. PubMed  Europe PubMed DOI
  16. Ouyang,M., Jia,M., Chang,Z., Wang,Y., Wang,K., Gao,X. and Tang,B.
    Precise prostate cancer diagnosis using fluorescent nanoprobes for detecting PSA and PSMA in serum
    Chem Commun (Camb)60, 5181-5184. PubMed  Europe PubMed DOI
  17. Peters,D.E.
    Targeting glutamate carboxypeptidase II in IBD
    Adv Pharmacol101, 265-285. PubMed  Europe PubMed DOI  V
  18. Savoy,E.A., Olatunji,F.P., Mesbahi,N., Ballard,R.K., Lovingier,C.L., Hendricksen,A.T., Fulton,M.D. and Berkman,C.E.
    PSMA-targeted SMART molecules outfitted with SN38
    Bioorg Med Chem Lett101, 129657-129657. PubMed  Europe PubMed DOI
  19. Shirke,A.A., Walker,E., Chavali,S., Ramamurthy,G., Zhang,L., Panigrahi,A., Basilion,J.P. and Wang,X.
    A Synergistic Strategy Combining Chemotherapy and Photodynamic Therapy to Eradicate Prostate Cancer
    Int J Mol Sci25, PubMed  Europe PubMed DOI
  20. Waibel,S., Graf,N., Storz,J., Schultze-Seemann,S., Lauw,S., Gratzke,C., Bruckner,R., Wolf,P. and Wolf,I.
    Photoimmunotherapy of Prostate Cancer With Antibody and Fab Fragments Targeting the Prostate Specific Membrane Antigen
    Anticancer Res44, 2343-2348. PubMed  Europe PubMed DOI
  21. Wang,Z., Zhu,B., Jiang,F., Chen,X., Wang,G., Ding,N., Song,S., Xu,X. and Zhang,W.
    Design, synthesis and evaluation of novel prostate-specific membrane antigen-targeted aryl [(18)F]fluorosulfate PET tracers
    Bioorg Med Chem106, 117753-117753. PubMed  Europe PubMed DOI
  22. Yoon,H., Savoy,E.A., Mesbahi,N., Hendricksen,A.T., March,G.L., Fulton,M.D., Backer,B.S. and Berkman,C.E.
    A PSMA-targeted doxorubicin small-molecule drug conjugate
    Bioorg Med Chem Lett104, 129712-129712. PubMed  Europe PubMed DOI
    23. 2023
  23. Eltit,F., Robinson,N., Yu,P.L.I., Pandey,M., Lozada,J., Guo,Y., Sharma,M., Ozturan,D., Ganier,L., Belanger,E., Lack,N.A., Perrin,D.M., Cox,M.E. and Goldenberg,S.L.
    The "Ins and Outs" of Prostate Specific Membrane Antigen (PSMA) as Specific Target in Prostate Cancer Therapy
    Adv Exp Med Biol1408, 291-308. PubMed  Europe PubMed DOI
  24. Hasnowo,L.A., Larkina,M.S., Plotnikov,E., Bodenko,V., Yuldasheva,F., Stasyuk,E., Petrov,S.A., Zyk,N.Y., Machulkin,A.E., Vorozhtsov,N.I., Beloglazkina,E.K., Nenajdenko,V.G., Tolmachev,V., Orlova,A., Majouga,A.G. and Yusubov,M.S.
    Synthesis, (123)I-Radiolabeling Optimization, and Initial Preclinical Evaluation of Novel Urea-Based PSMA Inhibitors with a Tributylstannyl Prosthetic Group in Their Structures
    Int J Mol Sci24, PubMed  Europe PubMed DOI
  25. Lee,Z., Heston,W.D., Wang,X. and Basilion,J.P.
    GCP III is not the "off-target" for urea-based PSMA ligands
    Eur J Nucl Med Mol Imaging50, 2944-2946. PubMed  Europe PubMed DOI
  26. Notohamiprodjo,S., Eiber,M., Lohrmann,C. and Weber,W.A.
    Reply: PSMA Is Not Specific to Prostate Cancer
    J Nucl Med64, 1326-1327. PubMed  Europe PubMed DOI
  27. Peters,D.E., Norris,L.D., Tenora,L., Snajdr,I., Ponti,A.K., Zhu,X., Sakamoto,S., Veeravalli,V., Pradhan,M., Alt,J., Thomas,A.G., Majer,P., Rais,R., McDonald,C. and Slusher,B.S.
    A gut-restricted glutamate carboxypeptidase II inhibitor reduces monocytic inflammation and improves preclinical colitis
    Sci Transl Med15, eabn7491-eabn7491. PubMed  Europe PubMed DOI  I
  28. Song,B. and Hong,S.K.
    The era of prostate-specific membrane antigen for the diagnosis and treatment of prostate cancer: A novel horizon
    Investig Clin Urol64, 197-199. PubMed  Europe PubMed DOI
  29. Strauss,A.S., Bolenz,C., Beer,A.J., Zengerling,F., Beer,M. and Miksch,J.
    [Opportunities for prostate-specific membrane antigen hybrid imaging in prostate cancer]
    Urologie62, 1153-1159. PubMed  Europe PubMed DOI  V
  30. Sui,Y., Duan,X., Zhang,J., Chu,Y. and Yang,X.
    Synthesis and characterization of a novel (68)Ga-labeled p-bromobenzyl lysine-urea-ODAP PSMA inhibitor
    Bioorg Med Chem Lett91, 129382-129382. PubMed  Europe PubMed DOI  I
  31. Thomsen,M.B., Landau,A.M., Bender,D. and Cumming,P.
    Autoradiographic characterization of [(18) F]PSMA-1007 binding in rat brain
    Synapse77, e22280-e22280. PubMed  Europe PubMed DOI
  32. Wang,X., Chen,Y., Xiong,Y., Zhang,L., Wang,B., Liu,Y. and Cui,M.
    Design and Characterization of Squaramic Acid-Based Prostate-Specific Membrane Antigen Inhibitors for Prostate Cancer
    J Med Chem66, 6889-6904. PubMed  Europe PubMed DOI  I
  33. Yang,X., Nao,S.C., Lin,C., Kong,L., Wang,J., Ko,C.N., Liu,J., Ma,D.L., Leung,C.H. and Wang,W.
    A cell-impermeable luminogenic probe for near-infrared imaging of prostate-specific membrane antigen in prostate cancer microenvironments
    Eur J Med Chem259, 115659-115659. PubMed  Europe PubMed DOI
  34. Zhang,L., Shi,X., Li,Y., Duan,X., Yang,X., Hu,Z. and Cui,M.
    An NIR-II Probe with High PSMA Affinity Demonstrates an Unexpected Excellent Bone Imaging Ability
    J Med Chem66, 16441-16454. PubMed  Europe PubMed DOI
  35. Zyk,N.Y., Garanina,A.S., Plotnikova,E.A., Ber,A.P., Nimenko,E.A., Dashkova,N.S., Uspenskaia,A.A., Shafikov,R.R., Skvortsov,D.A., Petrov,S.A., Pankratov,A.A., Zyk,N.V., Majouga,A.G., Beloglazkina,E.K. and Machulkin,A.E.
    Synthesis of Prostate-Specific Membrane Antigen-Targeted Bimodal Conjugates of Cytotoxic Agents and Antiandrogens and Their Comparative Assessment with Monoconjugates
    Int J Mol Sci24, PubMed  Europe PubMed DOI
    36. 2022
  36. Bim,D., Navratil,M., Gutten,O., Konvalinka,J., Kutil,Z., Culka,M., Navratil,V., Alexandrova,A.N., Barinka,C. and Rulisek,L.
    Predicting Effects of Site-Directed Mutagenesis on Enzyme Kinetics by QM/MM and QM Calculations: A Case of Glutamate Carboxypeptidase II
    J Phys Chem B126, 132-143. PubMed  Europe PubMed DOI
  37. Boinapally,S., Lisok,A., Lofland,G., Minn,I., Yan,Y., Jiang,Z., Shin,M.J., Merino,V.F., Zheng,L., Brayton,C., Pomper,M.G. and Banerjee,S.R.
    Hetero-bivalent agents targeting FAP and PSMA
    Eur J Nucl Med Mol Imaging49, 4369-4381. PubMed  Europe PubMed DOI
  38. Chen,Y., Minn,I., Rowe,S.P., Lisok,A., Chatterjee,S., Brummet,M., Banerjee,S.R., Mease,R.C. and Pomper,M.G.
    A Series of PSMA-Targeted Near-Infrared Fluorescent Imaging Agents
    Biomolecules12, PubMed  Europe PubMed DOI
  39. Hadi,M., Akbari,A., Dehbidi,G.R., Arabsolghar,R. and Bahmani,T.
    Expression and Purification of Human Granzyme B Fusion Protein to Induce Targeted Apoptosis in PSMA Positive Prostate Cancer Cells
    Protein Pept Lett29, 631-640. PubMed  Europe PubMed DOI
  40. Hawkey,N.M., Sartor,A.O., Morris,M.J. and Armstrong,A.J.
    Prostate-specific membrane antigen-targeted theranostics: past, present, and future approaches
    Clin Adv Hematol Oncol20, 227-238. PubMed  Europe PubMed  V
  41. Hirata,S., Mishiro,K., Higashi,T., Fuchigami,T., Munekane,M., Arano,Y., Kinuya,S. and Ogawa,K.
    Synthesis and evaluation of a multifunctional probe with a high affinity for prostate-specific membrane antigen (PSMA) and bone
    Nucl Med Biol114-115, 34-41. PubMed  Europe PubMed DOI
  42. Hong,X., Mao,L., Xu,L., Hu,Q. and Jia,R.
    Prostate-specific membrane antigen modulates the progression of prostate cancer by regulating the synthesis of arginine and proline and the expression of androgen receptors and Fos proto-oncogenes
    Bioengineered13, 995-1012. PubMed  Europe PubMed DOI  K
  43. Imperio,D., Grolla,A.A., Moro,M., Bortolotto,V., Del Grosso,E., Genazzani,A.A. and Panza,L.
    Functionalization of beta-cyclodextrin with a urea-based PSMA ligand and preliminary studies on targeting prostate cancer cells
    Bioorg Med Chem Lett73, 128890-128890. PubMed  Europe PubMed DOI
  44. Jia,A.Y., Kashani,R., Zaorsky,N.G., Baumann,B.C., Michalski,J., Zoberi,J.E., Kiess,A.P. and Spratt,D.E.
    Lutetium-177 Prostate-Specific Membrane Antigen Therapy: A Practical Review
    Pract Radiat Oncol12, 294-299. PubMed  Europe PubMed DOI  V
  45. Kondo,Y., Kimura,H., Sasaki,I., Watanabe,S., Ohshima,Y., Yagi,Y., Hattori,Y., Koda,M., Kawashima,H., Yasui,H. and Ishioka,N.S.
    Copper-mediated radioiodination and radiobromination via aryl boronic precursor and its application to (125)I/(77)Br-labeled prostate-specific membrane antigen imaging probes
    Bioorg Med Chem69, 116915-116915. PubMed  Europe PubMed DOI
  46. Li,Y., Duan,X., Xu,H., Zhang,J., Zhou,H., Zhang,X., Zhang,J., Yang,Z., Hu,Z., Zhang,N., Tian,J. and Yang,X.
    Optimization of ODAP-Urea-based dual-modality PSMA targeting probes for sequential PET-CT and optical imaging
    Bioorg Med Chem66, 116810-116810. PubMed  Europe PubMed DOI
  47. Madan,R.A., Mena,E., Lindenberg,L. and Choyke,P.L.
    With New Technology Comes Great Responsibility: Prostate-Specific Membrane Antigen Imaging in Recurrent Prostate Cancer
    J Clin Oncol40, 3015-3019. PubMed  Europe PubMed DOI
  48. Olatunji,F.P., Pun,M., Herman,J.W., Romero,O., Maniatopoulos,M., Latoche,J.D., Parise,R.A., Guo,J., Beumer,J.H., Anderson,C.J. and Berkman,C.E.
    Modular Smart Molecules for PSMA-Targeted Chemotherapy
    Mol Cancer Ther21, 1701-1709. PubMed  Europe PubMed DOI
  49. Yang,J.U., Kim,S., Ahn,J.H., Kim,M.H., Kil,H.S., Chi,D.Y., Lee,K.C., Lee,Y.J. and Park,J.A.
    Feasibility of Gd-Based prostate cancer targeted magnetic resonance agents using prostate specific membrane antigen
    Biochem Biophys Res Commun607, 152-157. PubMed  Europe PubMed DOI
  50. Yuan,W., Liu,B., Sanda,M., Wei,R., Benicky,J., Novakova,Z., Barinka,C. and Goldman,R.
    Glycoforms of human prostate-specific membrane antigen (PSMA) in human cells and prostate tissue
    Prostate82, 132-144. PubMed  Europe PubMed DOI
  51. Zha,Z., Choi,S.R., Li,L., Zhao,R., Ploessl,K., Yao,X., Alexoff,D., Zhu,L. and Kung,H.F.
    New PSMA-Targeting Ligands: Transformation from Diagnosis (Ga-68) to Radionuclide Therapy (Lu-177)
    J Med Chem65, 13001-13012. PubMed  Europe PubMed DOI
  52. Zhang,X., Chen,K., Jiang,K., He,J., An,Y., He,Z. and Sun,F.
    [Prokaryotic expression of prostate-specific membrane antigen (PSMA) nanoantibody gene and screening of natural phage nanoantibody library]
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi38, 1030-1035. PubMed  Europe PubMed
  53. Zyk,N.Y., Ber,A.P., Nimenko,E.A., Shafikov,R.R., Evteev,S.A., Petrov,S.A., Uspenskaya,A.A., Dashkova,N.S., Ivanenkov,Y.A., Skvortsov,D.A., Beloglazkina,E.K., Majouga,A.G. and Machulkin,A.E.
    Synthesis and initial in vitro evaluation of PSMA-targeting ligands with a modified aromatic moiety at the lysine epsilon-nitrogen atom
    Bioorg Med Chem Lett71, 128840-128840. PubMed  Europe PubMed DOI
    54. 2021
  54. Frontera,A. and Bauza,A.
    Glutamate carboxypeptidase II as a model system for designing host-guest units: a theoretical approach
    Org Biomol Chem19, 7816-7821. PubMed  Europe PubMed DOI
  55. Plichta,K.A., Graves,S.A. and Buatti,J.M.
    Prostate-Specific Membrane Antigen (PSMA) Theranostics for Treatment of Oligometastatic Prostate Cancer
    Int J Mol Sci22, PubMed  Europe PubMed DOI
  56. Zhang,L., Shi,X., Li,Y., Duan,X., Zhang,Z., Fu,H., Yang,X., Tian,J., Hu,Z. and Cui,M.
    Visualizing Tumors in Real Time: A Highly Sensitive PSMA Probe for NIR-II Imaging and Intraoperative Tumor Resection
    J Med Chem64, 7735-7745. PubMed  Europe PubMed DOI
    57. 2020
  57. Abecassis,J.P., Ghazzar,N., Peyromaure,M. and Giraud,P.
    Prostate imaging: Contribution of PET PSMA and MRI
    Cancer Radiother24, 423-428. PubMed  Europe PubMed DOI
  58. Vornov,J.J., Peters,D., Nedelcovych,M., Hollinger,K., Rais,R. and Slusher,B.S.
    Looking for drugs in all the wrong places: use of GCPII inhibitors outside the brain
    Neurochem Res45, 1256-1267. PubMed  Europe PubMed DOI
    59. 2019
  59. Barinka,C., Novakova,Z., Hin,N., Bim,D., Ferraris,D.V., Duvall,B., Kabarriti,G., Tsukamoto,R., Budesinsky,M., Motlova,L., Rojas,C., Slusher,B.S., Rokob,T.A., Rulisek,L. and Tsukamoto,T.
    Structural and computational basis for potent inhibition of glutamate carboxypeptidase II by carbamate-based inhibitors
    Bioorg Med Chem27, 255-264. PubMed  Europe PubMed DOI  I
  60. Neale,J.H. and Yamamoto,T.
    N-acetylaspartylglutamate (NAAG) and glutamate carboxypeptidase II: an abundant peptide neurotransmitter-enzyme system with multiple clinical applications
    Prog Neurobiol101722-101722. PubMed  Europe PubMed DOI
    61. 2018
  61. Choi,J.Y., Ko,J.H. and Jo,S.A.
    HDAC1 regulates the stability of glutamate carboxypeptidase II protein by modulating acetylation status of lysine 479 residue
    Biochem Biophys Res Commun497, 416-423. PubMed  Europe PubMed DOI
  62. Endepols,H., Mottaghy,F.M., Simsekyilmaz,S., Bucerius,J., Vogt,F., Winz,O., Richarz,R., Krapf,P., Neumaier,B., Zlatopolskiy,B.D. and Morgenroth,A.
    In vivo molecular imaging of glutamate carboxypeptidase II expression in re-endothelialisation after percutaneous balloon denudation in a rat model
    Sci Rep8, 7411-7411. PubMed  Europe PubMed DOI  L
  63. Ptacek,J., Nedvedova,J., Navratil,M., Havlinova,B., Konvalinka,J. and Barinka,C.
    The calcium-binding site of human glutamate carboxypeptidase II is critical for dimerization, thermal stability, and enzymatic activity
    Protein Sci27, 1575-1584. PubMed  Europe PubMed DOI
  64. Wu,W., Xu,S., Wang,J., Zhang,K., Zhang,M., Cao,Y., Ren,H., Zheng,D. and Zhong,C.
    Metabolite differences between glutamate carboxypeptidase II gene knockout mice and their wild-type littermates after traumatic brain injury: a 7-tesla (1)H-MRS study
    BMC Neurosci19, 75-75. PubMed  Europe PubMed DOI  K  U
  65. Wurzer,A., Pollmann,J., Schmidt,A., Reich,D., Wester,H.J. and Notni,J.
    Molar activity of Ga-68 labeled PSMA inhibitor conjugates determines PET imaging results
    Mol Pharm15, 4296-4302. PubMed  Europe PubMed DOI  I
    66. 2017
  66. Hicks,C., Gregg,R.A., Nayak,S.U., Cannella,L.A., Schena,G.J., Tallarida,C.S., Reitz,A.B., Smith,G.R. and Rawls,S.M.
    Glutamate carboxypeptidase II (GCPII) inhibitor 2-PMPA reduces rewarding effects of the synthetic cathinone MDPV in rats: a role for N-acetylaspartylglutamate (NAAG)
    Psychopharmacology (Berl)234, 1671-1681. PubMed  Europe PubMed DOI  I
  67. Knedlik,T., Vorlova,B., Navratil,V., Tykvart,J., Sedlak,F., Vaculin,S., Franek,M., Sacha,P. and Konvalinka,J.
    Mouse glutamate carboxypeptidase II (GCPII) has a similar enzyme activity and inhibition profile but a different tissue distribution to human GCPII
    FEBS Open Bio7, 1362-1378. PubMed  Europe PubMed DOI
  68. Rais,R., Vavra,J., Tichy,T., Dash,R.P., Gadiano,A.J., Tenora,L., Monincova,L., Barinka,C., Alt,J., Zimmermann,S.C., Slusher,C.E., Wu,Y., Wozniak,K., Majer,P., Tsukamoto,T. and Slusher,B.S.
    Discovery of a para-acetoxy-benzyl ester prodrug of a hydroxamate-based glutamate carboxypeptidase II inhibitor as oral therapy for neuropathic pain
    J Med Chem60, 7799-7809. PubMed  Europe PubMed DOI  I
    69. 2016
  69. Cao,Y., Gao,Y., Xu,S., Bao,J., Lin,Y., Luo,X., Wang,Y., Luo,Q., Jiang,J., Neale,J.H. and Zhong,C.
    Glutamate carboxypeptidase II gene knockout attenuates oxidative stress and cortical apoptosis after traumatic brain injury
    BMC Neurosci17, 15-15. PubMed  Europe PubMed DOI  K
  70. Conway,R.E., Rojas,C., Alt,J., Novakova,Z., Richardson,S.M., Rodrick,T.C., Fuentes,J.L., Richardson,N.H., Attalla,J., Stewart,S., Fahmy,B., Barinka,C., Ghosh,M., Shapiro,L.H. and Slusher,B.S.
    Prostate-specific membrane antigen (PSMA)-mediated laminin proteolysis generates a pro-angiogenic peptide
    Angiogenesis19, 487-500. PubMed  Europe PubMed DOI
  71. Dannoon,S., Ganguly,T., Cahaya,H., Geruntho,J.J., Galliher,M.S., Beyer,S.K., Choy,C.J., Hopkins,M.R., Regan,M., Blecha,J.E., Skultetyova,L., Drake,C.R., Jivan,S., Barinka,C., Jones,E.F., Berkman,C.E. and Vanbrocklin,H.F.
    Structure-activity relationship of (18)F-labeled phosphoramidate peptidomimetic prostate-specific membrane antigen (PSMA)-targeted inhibitor analogues for PET imaging of prostate cancer
    J Med Chem59, 5684-5694. PubMed  Europe PubMed DOI  L
  72. Derlin,T., Thiele,J., Weiberg,D., Thackeray,J.T., Puschel,K., Wester,H.J., Aguirre Davila,L., Larena-Avellaneda,A., Daum,G., Bengel,F.M. and Schumacher,U.
    Evaluation of 68Ga-glutamate carboxypeptidase II ligand positron emission tomography for clinical molecular imaging of atherosclerotic plaque neovascularization
    Arterioscler Thromb Vasc Biol36, 2213-2219. PubMed  Europe PubMed DOI  L
  73. Evans,J.C., Malhotra,M., Cryan,J.F. and O'Driscoll,C.M.
    The therapeutic and diagnostic potential of the prostate specific membrane antigen/glutamate carboxypeptidase II (PSMA/GCPII) in cancer and neurological disease
    Br J Pharmacol173, 3041-3079. PubMed  Europe PubMed DOI  V
  74. Ha,D., Bing,S.J., Ahn,G., Kim,J., Cho,J., Kim,A., Herath,K.H., Yu,H.S., Jo,S.A., Cho,I.H. and Jee,Y.
    Blocking glutamate carboxypeptidase II inhibits glutamate excitotoxicity and regulates immune responses in experimental autoimmune encephalomyelitis
    FEBS J283, 3438-3456. PubMed  Europe PubMed DOI  I
  75. Majer,P., Jancarik,A., Krecmerova,M., Tichy,T., Tenora,L., Wozniak,K., Wu,Y., Pommier,E., Ferraris,D., Rais,R. and Slusher,B.S.
    Discovery of orally available prodrugs of the glutamate carboxypeptidase II (GCPII) inhibitor 2-phosphonomethylpentanedioic acid (2-PMPA)
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  76. Naushad,S.M., Janaki Ramaiah,M., Stanley,B.A., Prasanna Lakshmi,S., Vishnu Priya,J., Hussain,T., Alrokayan,S.A. and Kutala,V.K.
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