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Literature for peptidase M27.001: tentoxilysin

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, I Inhibitor, P Specificity, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Popoff,M.R.
    Advances in Clostridial Neurotoxins: Passage of the Intestinal Barrier and Targeting of Specific Neuronal Cells
    Toxins (Basel) (2026) 18 PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2025
  2. Wilson,E.A., Bevans,A.N. and Baldwin,M.R.
    The Role of a Conserved Arg-Asp Pair in the Structure and Function of Tetanus Neurotoxin
    Toxins (Basel) (2025) 17 PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2024
  3. Behrensdorf-Nicol,H., Le Tallec,D., Sinitskaya,N., Behr-Gross,M.E. and Gongrich,C.
    Collaborative study for the characterisation of the BINACLE Assay for in vitro detection of tetanus toxicity in toxoids - Part 2
    Pharmeur Bio Sci Notes (2024) 2024, 162-192. PubMed  Europe PubMed
  4. Behrensdorf-Nicol,H., Kramer,B., Le Tallec,D., Sinitskaya,N. and Behr-Gross,M.E.
    Collaborative study for the characterisation of the BINACLE Assay for in vitro detection of tetanus toxicity in toxoids - Part 1
    Pharmeur Bio Sci Notes (2024) 2024, 127-161. PubMed  Europe PubMed
  5. Gregg,B.M., Gupta,S., Tepp,W.H. and Pellett,S.
    Expression of Recombinant Clostridial Neurotoxin by C. tetani
    Microorganisms (2024) 12 PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2022
  6. Fabris,F., Sostaric,P., Matak,I., Binz,T., Toffan,A., Simonato,M., Montecucco,C., Pirazzini,M. and Rossetto,O.
    Detection of VAMP Proteolysis by Tetanus and Botulinum Neurotoxin Type B In Vivo with a Cleavage-Specific Antibody
    Int J Mol Sci (2022) 23 PubMed  Europe PubMed DOI  PMC  EPMC
    7. 2021
  7. Megighian,A., Pirazzini,M., Fabris,F., Rossetto,O. and Montecucco,C.
    Tetanus and tetanus neurotoxin: From peripheral uptake to central nervous tissue targets
    J Neurochem (2021) PubMed  Europe PubMed DOI  V
    8. 2019
  8. Dong,M., Masuyer,G. and Stenmark,P.
    Botulinum and Tetanus Neurotoxins
    Annu Rev Biochem (2019) 88, 811-837. PubMed  Europe PubMed DOI  V
  9. Rossetto,O. and Montecucco,C.
    Tables of toxicity of Botulinum and Tetanus neurotoxins
    Toxins (Basel) (2019) 11 PubMed  Europe PubMed DOI
    10. 2017
  10. Burns,J.R., Lambert,G.S. and Baldwin,M.R.
    Insights into the mechanisms by which clostridial neurotoxins discriminate between gangliosides
    Biochemistry (2017) 56, 2571-2583. PubMed  Europe PubMed DOI
  11. Montal,M.
    Tetanus neurotoxin: conformational plasticity as an adaptive strategy
    EMBO Rep (2017) 18, 1268-1270. PubMed  Europe PubMed DOI
    12. 2015
  12. Ferecsko,A.S., Jiruska,P., Foss,L., Powell,A.D., Chang,W.C., Sik,A. and Jefferys,J.G.
    Structural and functional substrates of tetanus toxin in an animal model of temporal lobe epilepsy
    Brain Struct Funct (2015) 220, 1013-1029. PubMed  Europe PubMed DOI
    13. 2012
  13. Montecucco,C. and Rossetto,O.
    Tentoxilysin
    [ISSN:978-0-12-407744-7] (2012) 3, 655-660. DOI
    14. 2010
  14. Behrensdorf-Nicol,H.A., Bonifas,U., Kegel,B., Silberbach,K., Kramer,B. and Weisser,K.
    In vitro determination of tetanus toxicity by an endopeptidase assay linked to a ganglioside-binding step
    Toxicol In Vitro (2010) 24, 988-994. PubMed  Europe PubMed DOI  A
  15. Yeh,F.L., Dong,M., Yao,J., Tepp,W.H., Lin,G., Johnson,E.A. and Chapman,E.R.
    SV2 mediates entry of tetanus neurotoxin into central neurons
    PLoS Pathog (2010) 6, e1001207-e1001207. PubMed  Europe PubMed DOI  PMC  EPMC
    16. 2009
  16. Binz,T. and Rummel,A.
    Cell entry strategy of clostridial neurotoxins
    J Neurochem (2009) 109, 1584-1595. PubMed  Europe PubMed DOI
  17. Lebrun,I., Marques-Porto,R., Pereira,A.S., Pereira,A. and Perpetuo,E.A.
    Bacterial toxins: an overview on bacterial proteases and their action as virulence factors
    Mini Rev Med Chem (2009) 9, 820-828. PubMed  Europe PubMed DOI  V
    18. 2008
  18. Chen,C., Baldwin,M.R. and Barbieri,J.T.
    Molecular basis for tetanus toxin coreceptor interactions
    Biochemistry (2008) 47, 7179-7186. PubMed  Europe PubMed DOI
  19. Chen,S., Hall,C. and Barbieri,J.T.
    Substrate recognition of VAMP-2 by botulinum neurotoxin B and tetanus neurotoxin
    J Biol Chem (2008) 283, 21153-21159. PubMed  Europe PubMed DOI  PMC  EPMC  P
  20. Sikorra,S., Henke,T., Galli,T. and Binz,T.
    Substrate recognition mechanism of VAMP/synaptobrevin-cleaving clostridial neurotoxins
    J Biol Chem (2008) 283, 21145-21152. PubMed  Europe PubMed DOI
    21. 2007
  21. Kegel,B., Behrensdorf-Nicol,H.A., Bonifas,U., Silberbach,K., Klimek,J., Kramer,B. and Weisser,K.
    An in vitro assay for detection of tetanus neurotoxin activity: using antibodies for recognizing the proteolytically generated cleavage product
    Toxicol In Vitro (2007) 21, 1641-1649. PubMed  Europe PubMed DOI  A
    22. 2006
  22. Deinhardt,K., Berninghausen,O., Willison,H.J., Hopkins,C.R. and Schiavo,G.
    Tetanus toxin is internalized by a sequential clathrin-dependent mechanism initiated within lipid microdomains and independent of epsin1
    J Cell Biol (2006) 174, 459-471. PubMed  Europe PubMed DOI  PMC  EPMC
    23. 2005
  23. Breidenbach,M.A. and Brunger,A.T.
    2.3 A crystal structure of tetanus neurotoxin light chain
    Biochemistry (2005) 44, 7450-7457. PubMed  Europe PubMed DOI  S
  24. Rao,K.N., Kumaran,D., Binz,T. and Swaminathan,S.
    Structural analysis of the catalytic domain of tetanus neurotoxin
    Toxicon (2005) 45, 929-939. PubMed  Europe PubMed DOI  S
    25. 2004
  25. Montecucco,C. and Rossetto,O.
    Tentoxilysin
    [ISSN:0-12-079610-4] (2004) 2, 448-451.  V
  26. Montecucco,C., Rossetto,O. and Schiavo,G.
    Presynaptic receptor arrays for clostridial neurotoxins
    Trends Microbiol (2004) 12, 442-446. PubMed  Europe PubMed DOI
    27. 2001
  27. [YEAR:24-8-2001]Fotinou,C., Emsley,P., Black,I., Ando,H., Ishida,H., Kiso,M., Sinha,K.A., Fairweather,N.F. and Isaacs,N.W.
    The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin
    J Biol Chem (24-8-2001) 276, 32274-32281. PubMed  Europe PubMed DOI  S
  28. Rossetto,O., Caccin,P., Rigoni,M., Tonello,F., Bortoletto,N., Stevens,R.C. and Montecucco,C.
    Active-site mutagenesis of tetanus neurotoxin implicates TYR-375 and GLU-271 in metalloproteolytic activity
    Toxicon (2001) 39, 1151-1159. PubMed  Europe PubMed DOI
    29. 2000
  29. Herreros,J., Lalli,G., Montecucco,C. and Schiavo,G.
    Tetanus toxin fragment C binds to a protein present in neuronal cell lines and motoneurons
    J Neurochem (2000) 74, 1941-1950. PubMed  Europe PubMed
  30. Humeau,Y., Doussau,F., Grant,N.J. and Poulain,B.
    How botulinum and tetanus neurotoxins block neurotransmitter release
    Biochimie (2000) 82, 427-446. PubMed  Europe PubMed DOI
  31. Roques,B.P., Anne,C., Turcaud,S. and Fournie-Zaluski,M.C.
    Mechanism of action of clostridial neurotoxins and rational inhibitor design
    Biol Cell (2000) 92, 445-447. PubMed  Europe PubMed DOI  I
  32. Schiavo,G., Matteoli,M. and Montecucco,C.
    Neurotoxins affecting neuroexocytosis
    Physiol Rev (2000) 80, 717-766. PubMed  Europe PubMed  V
    33. 1999
  33. Cornille,F. and Roques,B.P.
    [Tetanus and botulinum toxins are zinc metallopeptidases: molecular mechanisms and inhibition of their neurotoxicity]
    J Soc Biol (1999) 193, 509-516. PubMed  Europe PubMed  I
  34. [YEAR:3-9-1999]Lacy,D.B. and Stevens,R.C.
    Sequence homology and structural analysis of the clostridial neurotoxins
    J Mol Biol (3-9-1999) 291, 1091-1104. PubMed  Europe PubMed DOI  S
  35. Li,L. and Singh,B.R.
    Structure-function relationship of clostridial neurotoxins
    J Toxicol Toxin Rev (1999) 18, 95-112.
  36. [YEAR:11-2-1999]Martin,L., Cornille,F., Turcaud,S., Meudal,H., Roques,B.P. and Fournie-Zaluski,M.C.
    Metallopeptidase inhibitors of tetanus toxin: a combinatorial approach
    J Med Chem (11-2-1999) 42, 515-525. PubMed  Europe PubMed DOI  I
  37. Najib,A., Pelliccioni,P., Gil,C. and Aguilera,J.
    Clostridium neurotoxins influence serotonin uptake and release differently in rat brain synaptosomes
    J Neurochem (1999) 72, 1991-1998. PubMed  Europe PubMed DOI
  38. [YEAR:28-2-1999]Pellizzari,R., Rossetto,O., Schiavo,G. and Montecucco,C.
    Tetanus and botulinum neurotoxins: mechanism of action and therapeutic uses
    Philos Trans R Soc Lond B Biol Sci (28-2-1999) 354, 259-268. PubMed  Europe PubMed DOI  PMC  EPMC
  39. Tonello,F., Pellizzari,R., Pasqualato,S., Grandi,G., Peggion,E. and Montecucco,C.
    Recombinant and truncated tetanus neurotoxin light chain: cloning, expression, purification, and proteolytic activity
    Protein Expr Purif (1999) 15, 221-227. PubMed  Europe PubMed DOI  E
  40. [YEAR:15-8-1999]Verderio,C., Coco,S., Bacci,A., Rossetto,O., De Camilli,P., Montecucco,C. and Matteoli,M.
    Tetanus toxin blocks the exocytosis of synaptic vesicles clustered at synapses but not of synaptic vesicles in isolated axons
    J Neurosci (15-8-1999) 19, 6723-6732. PubMed  Europe PubMed
    41. 1998
  41. [YEAR:27-8-1998]Martin,L., Cornille,F., Coric,P., Roques,B.P. and Fournie-Zaluski,M.C.
    beta-Amino-thiols inhibit the zinc metallopeptidase activity of tetanus toxin light chain
    J Med Chem (27-8-1998) 41, 3450-3460. PubMed  Europe PubMed DOI
  42. Meneghini,C. and Morante,S.
    The active site structure of tetanus neurotoxin resolved by multiple scattering analysis in X-ray absorption spectroscopy
    Biophys J (1998) 75, 1953-1963. PubMed  Europe PubMed DOI  PMC  EPMC
    43. 1997
  43. Deloye,F., Doussau,F. and Poulain,B.
    [Action mechanisms of botulinum neurotoxins and tetanus neurotoxins]
    C R Seances Soc Biol Fil (1997) 191, 433-450. PubMed  Europe PubMed
  44. Tonello,F., Schiavo,G. and Montecucco,C.
    Metal substitution of tetanus neurotoxin
    Biochem J (1997) 322, 507-510. PubMed  Europe PubMed  PMC  EPMC
    45. 1996
  45. Montecucco,C., Schiavo,G. and Rossetto,O.
    The mechanism of action of tetanus and botulinum neurotoxins
    Arch Toxicol Suppl (1996) 18, 342-354. PubMed  Europe PubMed  V
  46. Soleilhac,J.M., Cornille,F., Martin,L., Lenoir,C., Fournie-Zaluski,M.C. and Roques,B.P.
    A sensitive and rapid fluorescence-based assay for determination of tetanus toxin peptidase activity
    Anal Biochem (1996) 241, 120-127. PubMed  Europe PubMed DOI  A
  47. Tonello,F., Morante,S., Rossetto,O., Schiavo,G. and Montecucco,C.
    Tetanus and botulism neurotoxins: a novel group of zinc-endopeptidases
    Adv Exp Med Biol (1996) 389, 251-260. PubMed  Europe PubMed
    48. 1995
  48. De Filippis,V., Vangelista,L., Schiavo,G., Tonello,F. and Montecucco,C.
    Structural studies on the zinc-endopeptidase light chain of tetanus neurotoxin
    Eur J Biochem (1995) 229, 61-69. PubMed  Europe PubMed DOI
  49. Halpern,J.L. and Neale,E.A.
    Neurospecific binding, internalization, and retrograde axonal transport
    Curr Top Microbiol Immunol (1995) 195, 221-241. PubMed  Europe PubMed
  50. Schiavo,G. and Montecucco,C.
    Tetanus and botulism neurotoxins: isolation and assay
    Methods Enzymol (1995) 248, 643-652. PubMed  Europe PubMed DOI  A  V
  51. Sweeney,S.T., Broadie,K., Keane,J., Niemann,H. and O'Kane,C.J.
    Targeted expression of tetanus toxin light chain in Drosophila specifically eliminates synaptic transmission and causes behavioral defects
    Neuron (1995) 14, 341-351. PubMed  Europe PubMed
    52. 1994
  52. [YEAR:15-5-1994]Cornille,F., Goudreau,N., Ficheux,D., Niemann,H. and Roques,B.P.
    Solid-phase synthesis, conformational analysis and in vitro cleavage of synthetic human synaptobrevin II 1-93 by tetanus toxin L chain
    Eur J Biochem (15-5-1994) 222, 173-181. PubMed  Europe PubMed DOI
  53. Li,Y., Foran,P., Fairweather,N.F., de Paiva,A., Weller,U., Dougan,G. and Dolly,J.O.
    A single mutation in the recombinant light chain of tetanus toxin abolishes its proteolytic activity and removes the toxicity seen after reconstitution with native heavy chain
    Biochemistry (1994) 33, 7014-7020. PubMed  Europe PubMed  E
  54. Montecucco,C. and Schiavo,G.
    Mechanism of action of tetanus and botulinum neurotoxins
    Mol Microbiol (1994) 13, 1-8. PubMed  Europe PubMed DOI
    55. 1993
  55. [YEAR:22-7-1993]McMahon,H.T., Ushkaryov,Y.A., Edelmann,L., Link,E., Binz,T., Niemann,H., Jahn,R. and Sudhof,T.C.
    Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein
    Nature (22-7-1993) 364, 346-349. PubMed  Europe PubMed DOI
  56. Montecucco,C. and Schiavo,G.
    Tetanus and botulism neurotoxins: a new group of zinc proteases
    Trends Biochem Sci (1993) 18, 324-327. PubMed  Europe PubMed DOI
    57. 1992
  57. Fujii,N., Kimura,K., Yokosawa,N., Tsuzuki,K. and Oguma,K.
    A zinc-protease specific domain in botulinum and tetanus neurotoxins
    Toxicon (1992) 30, 1486-1488. PubMed  Europe PubMed DOI
  58. Schiavo,G., Benfenati,F., Poulain,B., Rossetto,O., Polverino de Laureto,P., DasGupta,B.R. and Montecucco,C.
    Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin
    Nature (1992) 359, 832-835. PubMed  Europe PubMed DOI
  59. Schiavo,G., Poulain,B., Rossetto,O., Benfenati,F., Tauc,L. and Montecucco,C.
    Tetanus toxin is a zinc protein and its inhibition of neurotransmitter release and protease activity depend on zinc
    EMBO J (1992) 11, 3577-3583. PubMed  Europe PubMed  PMC  EPMC
    60. 1989
  60. [YEAR:1-7-1989]Weller,U., Dauzenroth,M.E., Meyer zu Heringdorf,D. and Habermann,E.
    Chains and fragments of tetanus toxin. Separation, reassociation and pharmacological properties
    Eur J Biochem (1-7-1989) 182, 649-656. PubMed  Europe PubMed
    61. 1986
  61. Eisel,U., Jarausch,W., Goretzki,K., Henschen,A., Engels,J., Weller,U., Hudel,M., Habermann,E. and Niemann,H.
    Tetanus toxin: primary structure, expression in E. coli, and homology with botulinum toxins
    EMBO J (1986) 5, 2495-2502. PubMed  Europe PubMed  PMC  EPMC
  62. [YEAR:6-11-1986]Penner,R., Neher,E. and Dreyer,F.
    Intracellularly injected tetanus toxin inhibits exocytosis in bovine adrenal chromaffin cells
    Nature (6-11-1986) 324, 76-78. PubMed  Europe PubMed DOI
    63. 1985
  63. Ozutsumi,K., Sugimoto,N. and Matsuda,M.
    Rapid, simplified method for production and purification of tetanus toxin
    Appl Environ Microbiol (1985) 49, 939-943. PubMed  Europe PubMed  PMC  EPMC
    64. 1982
  64. Gill,D.M.
    Bacterial toxins: a table of lethal amounts
    Microbiol Rev (1982) 46, 86-94. PubMed  Europe PubMed  PMC  EPMC

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