Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase M27.001: tentoxilysin

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, I Inhibitor, P Specificity, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Behrensdorf-Nicol,H., Kramer,B., Le Tallec,D., Sinitskaya,N. and Behr-Gross,M.E.
    Collaborative study for the characterisation of the BINACLE Assay for in vitro detection of tetanus toxicity in toxoids - Part 1
    Pharmeur Bio Sci Notes2024, 127-161. PubMed  Europe PubMed
  2. Behrensdorf-Nicol,H., Le Tallec,D., Sinitskaya,N., Behr-Gross,M.E. and Gongrich,C.
    Collaborative study for the characterisation of the BINACLE Assay for in vitro detection of tetanus toxicity in toxoids - Part 2
    Pharmeur Bio Sci Notes2024, 162-192. PubMed  Europe PubMed
  3. Gregg,B.M., Gupta,S., Tepp,W.H. and Pellett,S.
    Expression of Recombinant Clostridial Neurotoxin by C. tetani
    Microorganisms12, PubMed  Europe PubMed DOI
    4. 2022
  4. Fabris,F., Sostaric,P., Matak,I., Binz,T., Toffan,A., Simonato,M., Montecucco,C., Pirazzini,M. and Rossetto,O.
    Detection of VAMP Proteolysis by Tetanus and Botulinum Neurotoxin Type B In Vivo with a Cleavage-Specific Antibody
    Int J Mol Sci23, PubMed  Europe PubMed DOI
    5. 2021
  5. Megighian,A., Pirazzini,M., Fabris,F., Rossetto,O. and Montecucco,C.
    Tetanus and tetanus neurotoxin: From peripheral uptake to central nervous tissue targets
    J Neurochem PubMed  Europe PubMed DOI  V
    6. 2019
  6. Dong,M., Masuyer,G. and Stenmark,P.
    Botulinum and Tetanus Neurotoxins
    Annu Rev Biochem88, 811-837. PubMed  Europe PubMed DOI  V
  7. Rossetto,O. and Montecucco,C.
    Tables of toxicity of Botulinum and Tetanus neurotoxins
    Toxins (Basel)11, PubMed  Europe PubMed DOI
    8. 2017
  8. Burns,J.R., Lambert,G.S. and Baldwin,M.R.
    Insights into the mechanisms by which clostridial neurotoxins discriminate between gangliosides
    Biochemistry56, 2571-2583. PubMed  Europe PubMed DOI
  9. Montal,M.
    Tetanus neurotoxin: conformational plasticity as an adaptive strategy
    EMBO Rep18, 1268-1270. PubMed  Europe PubMed DOI
    10. 2015
  10. Ferecsko,A.S., Jiruska,P., Foss,L., Powell,A.D., Chang,W.C., Sik,A. and Jefferys,J.G.
    Structural and functional substrates of tetanus toxin in an animal model of temporal lobe epilepsy
    Brain Struct Funct220, 1013-1029. PubMed  Europe PubMed DOI
    11. 2012
  11. Montecucco,C. and Rossetto,O.
    Tentoxilysin
    [ISSN:978-0-12-407744-7]3, 655-660. DOI
    12. 2010
  12. Behrensdorf-Nicol,H.A., Bonifas,U., Kegel,B., Silberbach,K., Kramer,B. and Weisser,K.
    In vitro determination of tetanus toxicity by an endopeptidase assay linked to a ganglioside-binding step
    Toxicol In Vitro24, 988-994. PubMed  Europe PubMed DOI  A
  13. Yeh,F.L., Dong,M., Yao,J., Tepp,W.H., Lin,G., Johnson,E.A. and Chapman,E.R.
    SV2 mediates entry of tetanus neurotoxin into central neurons
    PLoS Pathog6, e1001207-e1001207. PubMed  Europe PubMed DOI
    14. 2009
  14. Binz,T. and Rummel,A.
    Cell entry strategy of clostridial neurotoxins
    J Neurochem109, 1584-1595. PubMed  Europe PubMed DOI
  15. Lebrun,I., Marques-Porto,R., Pereira,A.S., Pereira,A. and Perpetuo,E.A.
    Bacterial toxins: an overview on bacterial proteases and their action as virulence factors
    Mini Rev Med Chem9, 820-828. PubMed  Europe PubMed DOI  V
    16. 2008
  16. Chen,C., Baldwin,M.R. and Barbieri,J.T.
    Molecular basis for tetanus toxin coreceptor interactions
    Biochemistry47, 7179-7186. PubMed  Europe PubMed DOI
  17. Chen,S., Hall,C. and Barbieri,J.T.
    Substrate recognition of VAMP-2 by botulinum neurotoxin B and tetanus neurotoxin
    J Biol Chem283, 21153-21159. PubMed  Europe PubMed DOI  P
  18. Sikorra,S., Henke,T., Galli,T. and Binz,T.
    Substrate recognition mechanism of VAMP/synaptobrevin-cleaving clostridial neurotoxins
    J Biol Chem283, 21145-21152. PubMed  Europe PubMed DOI
    19. 2007
  19. Kegel,B., Behrensdorf-Nicol,H.A., Bonifas,U., Silberbach,K., Klimek,J., Kramer,B. and Weisser,K.
    An in vitro assay for detection of tetanus neurotoxin activity: using antibodies for recognizing the proteolytically generated cleavage product
    Toxicol In Vitro21, 1641-1649. PubMed  Europe PubMed DOI  A
    20. 2006
  20. Deinhardt,K., Berninghausen,O., Willison,H.J., Hopkins,C.R. and Schiavo,G.
    Tetanus toxin is internalized by a sequential clathrin-dependent mechanism initiated within lipid microdomains and independent of epsin1
    J Cell Biol174, 459-471. PubMed  Europe PubMed DOI
    21. 2005
  21. Breidenbach,M.A. and Brunger,A.T.
    2.3 A crystal structure of tetanus neurotoxin light chain
    Biochemistry44, 7450-7457. PubMed  Europe PubMed DOI  S
  22. Rao,K.N., Kumaran,D., Binz,T. and Swaminathan,S.
    Structural analysis of the catalytic domain of tetanus neurotoxin
    Toxicon45, 929-939. PubMed  Europe PubMed DOI  S
    23. 2004
  23. Montecucco,C., Rossetto,O. and Schiavo,G.
    Presynaptic receptor arrays for clostridial neurotoxins
    Trends Microbiol12, 442-446. PubMed  Europe PubMed DOI
  24. Montecucco,C. and Rossetto,O.
    Tentoxilysin
    [ISSN:0-12-079610-4]2, 448-451.  V
    25. 2001
  25. [YEAR:24-8-2001]Fotinou,C., Emsley,P., Black,I., Ando,H., Ishida,H., Kiso,M., Sinha,K.A., Fairweather,N.F. and Isaacs,N.W.
    The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin
    J Biol Chem276, 32274-32281. PubMed  Europe PubMed DOI  S
  26. Rossetto,O., Caccin,P., Rigoni,M., Tonello,F., Bortoletto,N., Stevens,R.C. and Montecucco,C.
    Active-site mutagenesis of tetanus neurotoxin implicates TYR-375 and GLU-271 in metalloproteolytic activity
    Toxicon39, 1151-1159. PubMed  Europe PubMed DOI
    27. 2000
  27. Herreros,J., Lalli,G., Montecucco,C. and Schiavo,G.
    Tetanus toxin fragment C binds to a protein present in neuronal cell lines and motoneurons
    J Neurochem74, 1941-1950. PubMed  Europe PubMed
  28. Humeau,Y., Doussau,F., Grant,N.J. and Poulain,B.
    How botulinum and tetanus neurotoxins block neurotransmitter release
    Biochimie82, 427-446. PubMed  Europe PubMed DOI
  29. Roques,B.P., Anne,C., Turcaud,S. and Fournie-Zaluski,M.C.
    Mechanism of action of clostridial neurotoxins and rational inhibitor design
    Biol Cell92, 445-447. PubMed  Europe PubMed DOI  I
  30. Schiavo,G., Matteoli,M. and Montecucco,C.
    Neurotoxins affecting neuroexocytosis
    Physiol Rev80, 717-766. PubMed  Europe PubMed  V
    31. 1999
  31. Cornille,F. and Roques,B.P.
    [Tetanus and botulinum toxins are zinc metallopeptidases: molecular mechanisms and inhibition of their neurotoxicity]
    J Soc Biol193, 509-516. PubMed  Europe PubMed  I
  32. [YEAR:3-9-1999]Lacy,D.B. and Stevens,R.C.
    Sequence homology and structural analysis of the clostridial neurotoxins
    J Mol Biol291, 1091-1104. PubMed  Europe PubMed DOI  S
  33. Li,L. and Singh,B.R.
    Structure-function relationship of clostridial neurotoxins
    J Toxicol Toxin Rev18, 95-112.
  34. [YEAR:11-2-1999]Martin,L., Cornille,F., Turcaud,S., Meudal,H., Roques,B.P. and Fournie-Zaluski,M.C.
    Metallopeptidase inhibitors of tetanus toxin: a combinatorial approach
    J Med Chem42, 515-525. PubMed  Europe PubMed DOI  I
  35. Najib,A., Pelliccioni,P., Gil,C. and Aguilera,J.
    Clostridium neurotoxins influence serotonin uptake and release differently in rat brain synaptosomes
    J Neurochem72, 1991-1998. PubMed  Europe PubMed DOI
  36. [YEAR:28-2-1999]Pellizzari,R., Rossetto,O., Schiavo,G. and Montecucco,C.
    Tetanus and botulinum neurotoxins: mechanism of action and therapeutic uses
    Philos Trans R Soc Lond B Biol Sci354, 259-268. PubMed  Europe PubMed DOI
  37. Tonello,F., Pellizzari,R., Pasqualato,S., Grandi,G., Peggion,E. and Montecucco,C.
    Recombinant and truncated tetanus neurotoxin light chain: cloning, expression, purification, and proteolytic activity
    Protein Expr Purif15, 221-227. PubMed  Europe PubMed DOI  E
  38. [YEAR:15-8-1999]Verderio,C., Coco,S., Bacci,A., Rossetto,O., De Camilli,P., Montecucco,C. and Matteoli,M.
    Tetanus toxin blocks the exocytosis of synaptic vesicles clustered at synapses but not of synaptic vesicles in isolated axons
    J Neurosci19, 6723-6732. PubMed  Europe PubMed
    39. 1998
  39. [YEAR:27-8-1998]Martin,L., Cornille,F., Coric,P., Roques,B.P. and Fournie-Zaluski,M.C.
    beta-Amino-thiols inhibit the zinc metallopeptidase activity of tetanus toxin light chain
    J Med Chem41, 3450-3460. PubMed  Europe PubMed DOI
  40. Meneghini,C. and Morante,S.
    The active site structure of tetanus neurotoxin resolved by multiple scattering analysis in X-ray absorption spectroscopy
    Biophys J75, 1953-1963. PubMed  Europe PubMed DOI
    41. 1997
  41. Deloye,F., Doussau,F. and Poulain,B.
    [Action mechanisms of botulinum neurotoxins and tetanus neurotoxins]
    C R Seances Soc Biol Fil191, 433-450. PubMed  Europe PubMed
  42. Tonello,F., Schiavo,G. and Montecucco,C.
    Metal substitution of tetanus neurotoxin
    Biochem J322, 507-510. PubMed  Europe PubMed
    43. 1996
  43. Montecucco,C., Schiavo,G. and Rossetto,O.
    The mechanism of action of tetanus and botulinum neurotoxins
    Arch Toxicol Suppl18, 342-354. PubMed  Europe PubMed  V
  44. Soleilhac,J.M., Cornille,F., Martin,L., Lenoir,C., Fournie-Zaluski,M.C. and Roques,B.P.
    A sensitive and rapid fluorescence-based assay for determination of tetanus toxin peptidase activity
    Anal Biochem241, 120-127. PubMed  Europe PubMed DOI  A
  45. Tonello,F., Morante,S., Rossetto,O., Schiavo,G. and Montecucco,C.
    Tetanus and botulism neurotoxins: a novel group of zinc-endopeptidases
    Adv Exp Med Biol389, 251-260. PubMed  Europe PubMed
    46. 1995
  46. De Filippis,V., Vangelista,L., Schiavo,G., Tonello,F. and Montecucco,C.
    Structural studies on the zinc-endopeptidase light chain of tetanus neurotoxin
    Eur J Biochem229, 61-69. PubMed  Europe PubMed DOI
  47. Halpern,J.L. and Neale,E.A.
    Neurospecific binding, internalization, and retrograde axonal transport
    Curr Top Microbiol Immunol195, 221-241. PubMed  Europe PubMed
  48. Schiavo,G. and Montecucco,C.
    Tetanus and botulism neurotoxins: isolation and assay
    Methods Enzymol248, 643-652. PubMed  Europe PubMed DOI  A  V
  49. Sweeney,S.T., Broadie,K., Keane,J., Niemann,H. and O'Kane,C.J.
    Targeted expression of tetanus toxin light chain in Drosophila specifically eliminates synaptic transmission and causes behavioral defects
    Neuron14, 341-351. PubMed  Europe PubMed
    50. 1994
  50. [YEAR:15-5-1994]Cornille,F., Goudreau,N., Ficheux,D., Niemann,H. and Roques,B.P.
    Solid-phase synthesis, conformational analysis and in vitro cleavage of synthetic human synaptobrevin II 1-93 by tetanus toxin L chain
    Eur J Biochem222, 173-181. PubMed  Europe PubMed DOI
  51. Li,Y., Foran,P., Fairweather,N.F., de Paiva,A., Weller,U., Dougan,G. and Dolly,J.O.
    A single mutation in the recombinant light chain of tetanus toxin abolishes its proteolytic activity and removes the toxicity seen after reconstitution with native heavy chain
    Biochemistry33, 7014-7020. PubMed  Europe PubMed  E
  52. Montecucco,C. and Schiavo,G.
    Mechanism of action of tetanus and botulinum neurotoxins
    Mol Microbiol13, 1-8. PubMed  Europe PubMed DOI
    53. 1993
  53. [YEAR:22-7-1993]McMahon,H.T., Ushkaryov,Y.A., Edelmann,L., Link,E., Binz,T., Niemann,H., Jahn,R. and Sudhof,T.C.
    Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein
    Nature364, 346-349. PubMed  Europe PubMed DOI
  54. Montecucco,C. and Schiavo,G.
    Tetanus and botulism neurotoxins: a new group of zinc proteases
    Trends Biochem Sci18, 324-327. PubMed  Europe PubMed DOI
    55. 1992
  55. Fujii,N., Kimura,K., Yokosawa,N., Tsuzuki,K. and Oguma,K.
    A zinc-protease specific domain in botulinum and tetanus neurotoxins
    Toxicon30, 1486-1488. PubMed  Europe PubMed DOI
  56. Schiavo,G., Poulain,B., Rossetto,O., Benfenati,F., Tauc,L. and Montecucco,C.
    Tetanus toxin is a zinc protein and its inhibition of neurotransmitter release and protease activity depend on zinc
    EMBO J11, 3577-3583. PubMed  Europe PubMed
  57. Schiavo,G., Benfenati,F., Poulain,B., Rossetto,O., Polverino de Laureto,P., DasGupta,B.R. and Montecucco,C.
    Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin
    Nature359, 832-835. PubMed  Europe PubMed DOI
    58. 1989
  58. [YEAR:1-7-1989]Weller,U., Dauzenroth,M.E., Meyer zu Heringdorf,D. and Habermann,E.
    Chains and fragments of tetanus toxin. Separation, reassociation and pharmacological properties
    Eur J Biochem182, 649-656. PubMed  Europe PubMed
    59. 1986
  59. Eisel,U., Jarausch,W., Goretzki,K., Henschen,A., Engels,J., Weller,U., Hudel,M., Habermann,E. and Niemann,H.
    Tetanus toxin: primary structure, expression in E. coli, and homology with botulinum toxins
    EMBO J5, 2495-2502. PubMed  Europe PubMed
  60. [YEAR:6-11-1986]Penner,R., Neher,E. and Dreyer,F.
    Intracellularly injected tetanus toxin inhibits exocytosis in bovine adrenal chromaffin cells
    Nature324, 76-78. PubMed  Europe PubMed DOI
    61. 1985
  61. Ozutsumi,K., Sugimoto,N. and Matsuda,M.
    Rapid, simplified method for production and purification of tetanus toxin
    Appl Environ Microbiol49, 939-943. PubMed  Europe PubMed
    62. 1982
  62. Gill,D.M.
    Bacterial toxins: a table of lethal amounts
    Microbiol Rev46, 86-94. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use