Substrates for peptidase M24.017: methionyl aminopeptidase 1 (eukaryote)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase	P82610	1-767	Met1+Val-peptide	P	NT	-	-	-	Met	Val	Gln	Ser	Ser	Pitarch et al., 2001
alpha-glucosidase	Q02751	1-570	Met1+Ser-peptide	P	NT	-	-	-	Met	Ser	Glu	His	Lys	Geber et al., 1992
flagellin D	P0C6C6	1-377	Met1+Ala-peptide	P	NT	-	-	-	Met	Ala	Val	Asn	Val	Das et al., 1998
fructose-bisphosphate aldolase	Q9URB4	1-359	Met1+Ala-peptide	P	NT	-	-	-	Met	Ala	Pro	Pro	Ala	Pitarch et al., 2001
probable NADPH dehydrogenase	P43084	1-407	Met1+Thr-peptide	P	NT	-	-	-	Met	Thr	Ile	Glu	Ser	Madani et al., 1994
serine hydroxymethyltransferase, cytosolic	O13426	1-470	Met1+Ser-peptide	P	NT	-	-	-	Met	Ser	Ala	Tyr	Ala	Pitarch et al., 2004