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Literature for peptidase M24.017: methionyl aminopeptidase 1 (eukaryote)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

(Topics flags: S Structure, A Assay, P Specificity, I Inhibitor, K Knockout, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Sun,Q., Zhao,J., Wang,G., Wang,Y., Zhu,Y., Yan,Y., Chen,Z., Chen,Z., Feng,Z. and Zuo,S.
    Isolation of OsMetAP10, a Peptidase_M24 Superfamily Gene, Regulating Heading Date in Rice
    Biology (Basel) (2025) 14 PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2023
  2. Lee,Y., Kim,H., Lee,E., Hahn,H., Heo,Y., Jang,D.M., Kwak,K., Kim,H.J. and Kim,H.S.
    Structural insights into N-terminal methionine cleavage by the human mitochondrial methionine aminopeptidase, MetAP1D
    Sci Rep (2023) 13, 22326-22326. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2019
  3. Pillalamarri,V., Arya,T., Haque,N., Bala,S.C., Marapaka,A.K. and Addlagatta,A.
    Discovery of natural product ovalicin sensitive type 1 methionine aminopeptidases: molecular and structural basis
    Biochem J (2019) 476, 991-1003. PubMed  Europe PubMed DOI
    4. 2018
  4. Jonckheere,V., Fijalkowska,D. and Van Damme,P.
    Omics assisted N-terminal proteoform and protein expression profiling on methionine aminopeptidase 1 (MetAP1) deletion
    Mol Cell Proteomics (2018) 17, 694-708. PubMed  Europe PubMed DOI  K
    5. 2015
  5. Kang,J.M., Ju,J.W., Kim,J.Y., Ju,H.L., Lee,J., Lee,K.H., Lee,W.J., Sohn,W.M., Kim,T.S. and Na,B.K.
    Expression and biochemical characterization of a type I methionine aminopeptidase of Plasmodium vivax
    Protein Expr Purif (2015) 108C, 48-53. PubMed  Europe PubMed DOI  E
  6. Marschner,A. and Klein,C.D.
    Metal promiscuity and metal-dependent substrate preferences of Trypanosoma brucei methionine aminopeptidase 1
    Biochimie (2015) 115, 35-43. PubMed  Europe PubMed DOI
  7. Rachineni,K., Arya,T., Singarapu,K.K., Addlagatta,A. and Bharatam,J.
    Chemical shift assignments of zinc finger domain of methionine aminopeptidase 1 (MetAP1) from Homo sapiens
    Biomol NMR Assign (2015) 9, 351-353. PubMed  Europe PubMed DOI
    8. 2014
  8. Reddi,R., Arya,T., Kishor,C., Gumpena,R., Ganji,R.J., Bhukya,S. and Addlagatta,A.
    Selective targeting of the conserved active site cysteine of Mycobacterium tuberculosis methionine aminopeptidase with electrophilic reagents
    FEBS J (2014) 281, 4240-4248. PubMed  Europe PubMed DOI
    9. 2013
  9. Zhang,F., Bhat,S., Gabelli,S.B., Chen,X., Miller,M.S., Nacev,B.A., Cheng,Y.L., Meyers,D.J., Tenney,K., Shim,J.S., Crews,P., Amzel,L.M., Ma,D. and Liu,J.O.
    Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells
    J Med Chem (2013) 56, 3996-4016. PubMed  Europe PubMed DOI  I
  10. Zhang,P., Yang,X., Zhang,F., Gabelli,S.B., Wang,R., Zhang,Y., Bhat,S., Chen,X., Furlani,M., Amzel,L.M., Liu,J.O. and Ma,D.
    Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1
    Bioorg Med Chem (2013) 21, 2600-2617. PubMed  Europe PubMed DOI  I
    11. 2012
  11. Xu,W., Lu,J.P. and Ye,Q.Z.
    Structural analysis of bengamide derivatives as inhibitors of methionine aminopeptidases
    J Med Chem (2012) 55, 8021-8027. PubMed  Europe PubMed DOI  PMC  EPMC  I
    12. 2011
  12. Shapiro,A.B., Gao,N., Thresher,J., Walkup,G.K. and Whiteaker,J.
    A high-throughput absorbance-based assay for methionine produced by methionine aminopeptidase using S-adenosyl-L-methionine synthetase
    J Biomol Screen (2011) 16, 494-505. PubMed  Europe PubMed DOI  A
    13. 2010
  13. Altmeyer,M.A., Marschner,A., Schiffmann,R. and Klein,C.D.
    Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors
    Bioorg Med Chem Lett (2010) 20, 4038-4044. PubMed  Europe PubMed DOI  I
    14. 2008
  14. Haldar,M.K., Scott,M.D., Sule,N., Srivastava,D.K. and Mallik,S.
    Synthesis of barbiturate-based methionine aminopeptidase-1 inhibitors
    Bioorg Med Chem Lett (2008) 18, 2373-2376. PubMed  Europe PubMed DOI  PMC  EPMC  I
    15. 2006
  15. Addlagatta,A. and Matthews,B.W.
    Structure of the angiogenesis inhibitor ovalicin bound to its noncognate target, human Type 1 methionine aminopeptidase
    Protein Sci (2006) 15, 1842-1848. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
  16. Hu,X., Addlagatta,A., Matthews,B.W. and Liu,J.O.
    Identification of pyridinylpyrimidines as inhibitors of human methionine aminopeptidases
    Angew Chem Int Ed Engl (2006) 45, 3772-3775. PubMed  Europe PubMed DOI  S  I
  17. Hu,X., Addlagatta,A., Lu,J., Matthews,B.W. and Liu,J.O.
    Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression
    Proc Natl Acad Sci U S A (2006) 103, 18148-18153. PubMed  Europe PubMed DOI  PMC  EPMC
    18. 2005
  18. Addlagatta,A., Hu,X., Liu,J.O. and Matthews,B.W.
    Structural basis for the functional differences between type I and type II human methionine aminopeptidases
    Biochemistry (2005) 44, 14741-14749. PubMed  Europe PubMed DOI  S  I
    19. 2004
  19. Bradshaw,R.A., Yi,E. and Walker,K.W.
    Methionyl aminopeptidase type I
    [ISSN:0-12-079610-4] (2004) 2, 911-917.  V
  20. Giglione,C., Boularot,A. and Meinnel,T.
    Protein N-terminal methionine excision
    Cell Mol Life Sci (2004) 61, 1455-1474. PubMed  Europe PubMed DOI
  21. [YEAR:5-1-2004]Hu,X., Zhu,J., Srivathsan,S. and Pei,D.
    Peptidyl hydroxamic acids as methionine aminopeptidase inhibitors
    Bioorg Med Chem Lett (5-1-2004) 14, 77-79. PubMed  Europe PubMed DOI  I
  22. [YEAR:22-6-2004]Li,J.Y., Chen,L.L., Cui,Y.M., Luo,Q.L., Gu,M., Nan,F.J. and Ye,Q.Z.
    Characterization of full length and truncated type I human methionine aminopeptidases expressed from Escherichia coli
    Biochemistry (22-6-2004) 43, 7892-7898. PubMed  Europe PubMed DOI
  23. [YEAR:14-5-2004]Li,J.Y., Cui,Y.M., Chen,L.L., Gu,M., Li,J., Nan,F.J. and Ye,Q.Z.
    Mutations at the S1 sites of methionine aminopeptidases from Escherichia coli and Homo sapiens reveal the residues critical for substrate specificity
    J Biol Chem (14-5-2004) 279, 21128-21134. PubMed  Europe PubMed DOI  P
    24. 2003
  24. [YEAR:19-6-2003]Luo,Q.L., Li,J.Y., Liu,Z.Y., Chen,L.L., Li,J., Qian,Z., Shen,Q., Li,Y., Lushington,G.H., Ye,Q.Z. and Nan,F.J.
    Discovery and structural modification of inhibitors of methionine aminopeptidases from Escherichia coli and Saccharomyces cerevisiae
    J Med Chem (19-6-2003) 46, 2631-2640. PubMed  Europe PubMed DOI  I
  25. [YEAR:26-12-2003]Towbin,H., Bair,K.W., DeCaprio,J.A., Eck,M.J., Kim,S., Kinder,F.R., Morollo,A., Mueller,D.R., Schindler,P., Song,H.K., van Oostrum,J., Versace,R.W., Voshol,H., Wood,J., Zabludoff,S. and Phillips,P.E.
    Proteomics-based target identification: bengamides as a new class of methionine aminopeptidase inhibitors
    J Biol Chem (26-12-2003) 278, 52964-52971. PubMed  Europe PubMed DOI  I
    26. 2002
  26. [YEAR:1-2-2002]Chen,S., Vetro,J.A. and Chang,Y.H.
    The specificity in vivo of two distinct methionine aminopeptidases in Saccharomyces cerevisiae
    Arch Biochem Biophys (1-2-2002) 398, 87-93. PubMed  Europe PubMed DOI
  27. Vetro,J.A. and Chang,Y.H.
    Yeast methionine aminopeptidase type 1 is ribosome-associated and requires its N-terminal zinc finger domain for normal function in vivo
    J Cell Biochem (2002) 85, 678-688. PubMed  Europe PubMed DOI
    28. 2000
  28. Datta,B.
    MAPs and POEP of the roads from prokaryotic to eukaryotic kingdoms
    Biochimie (2000) 82, 95-107. PubMed  Europe PubMed DOI  V
  29. [YEAR:7-3-2000]Lowther,W.T. and Matthews,B.W.
    Structure and function of the methionine aminopeptidases
    Biochim Biophys Acta (7-3-2000) 1477, 157-167. PubMed  Europe PubMed DOI  S  I
  30. [YEAR:10-4-2000]Zhou,Y., Guo,X.C., Yi,T., Yoshimoto,T. and Pei,D.
    Two continuous spectrophotometric assays for methionine aminopeptidase
    Anal Biochem (10-4-2000) 280, 159-165. PubMed  Europe PubMed DOI  A
    31. 1999
  31. Walker,K.W., Yi,E. and Bradshaw,R.A.
    Yeast (Saccharomyces cerevisiae) methionine aminopeptidase I: rapid purification and improved activity assay
    Biotechnol Appl Biochem (1999) 29, 157-163. PubMed  Europe PubMed  A
  32. [YEAR:7-5-1999]Walker,K.W. and Bradshaw,R.A.
    Yeast methionine aminopeptidase I. Alteration of substrate specificity by site-directed mutagenesis
    J Biol Chem (7-5-1999) 274, 13403-13409. PubMed  Europe PubMed DOI  E
    33. 1998
  33. Walker,K.W. and Bradshaw,R.A.
    Yeast methionine aminopeptidase I can utilize either Zn2+ or Co2+ as a cofactor: a case of mistaken identity?
    Protein Sci (1998) 7, 2684-2687. PubMed  Europe PubMed DOI  PMC  EPMC
    34. 1997
  34. [YEAR:15-11-1997]Klinkenberg,M., Ling,C. and Chang,Y.H.
    A dominant negative mutation in Saccharomyces cerevisiae methionine aminopeptidase-1 affects catalysis and interferes with the function of methionine aminopeptidase-2
    Arch Biochem Biophys (15-11-1997) 347, 193-200. PubMed  Europe PubMed DOI
    35. 1996
  35. Keeling,P.J. and Doolittle,W.F.
    Methionine aminopeptidase-1: the MAP of the mitochondrion?
    Trends Biochem Sci (1996) 21, 285-286. PubMed  Europe PubMed
    36. 1995
  36. Arfin,S.M., Kendall,R.L., Hall,L., Weaver,L.H., Stewart,A.E., Matthews,B.W. and Bradshaw,R.A.
    Eukaryotic methionyl aminopeptidases: two classes of cobalt-dependent enzymes
    Proc Natl Acad Sci U S A (1995) 92, 7714-7718. PubMed  Europe PubMed DOI  PMC  EPMC
  37. Li,X. and Chang,Y.H.
    Amino-terminal protein processing in Saccharomyces cerevisiae is an essential function that requires two distinct methionine aminopeptidases
    Proc Natl Acad Sci U S A (1995) 92, 12357-12361. PubMed  Europe PubMed DOI  PMC  EPMC
  38. Zuo,S., Guo,Q., Ling,C. and Chang,Y.H.
    Evidence that two zinc fingers in the methionine aminopeptidase from Saccharomyces cerevisiae are important for normal growth
    Mol Gen Genet (1995) 246, 247-253. PubMed  Europe PubMed DOI
    39. 1992
  39. Chang,Y.H., Teichert,U. and Smith,J.A.
    Molecular cloning, sequencing, deletion, and overexpression of a methionine aminopeptidase gene from Saccharomyces cerevisiae
    J Biol Chem (1992) 267, 8007-8011. PubMed  Europe PubMed
    40. 1990
  40. [YEAR:15-11-1990]Chang,Y.H., Teichert,U. and Smith,J.A.
    Purification and characterization of a methionine aminopeptidase from Saccharomyces cerevisiae
    J Biol Chem (15-11-1990) 265, 19892-19897. PubMed  Europe PubMed
  41. [YEAR:15-11-1990]Moerschell,R.P., Hosokawa,Y., Tsunasawa,S. and Sherman,F.
    The specificities of yeast methionine aminopeptidase and acetylation of amino-terminal methionine in vivo. Processing of altered iso-1-cytochromes c created by oligonucleotide transformation
    J Biol Chem (15-11-1990) 265, 19638-19643. PubMed  Europe PubMed
    42. 1988
  42. [YEAR:15-6-1988]Boissel,J.P., Kasper,T.J. and Bunn,H.F.
    Cotranslational amino-terminal processing of cytosolic proteins. Cell-free expression of site-directed mutants of human hemoglobin
    J Biol Chem (15-6-1988) 263, 8443-8449. PubMed  Europe PubMed
    43. 1987
  43. [YEAR:15-12-1987]Huang,S., Elliott,R.C., Liu,P.S., Koduri,R.K., Weickmann,J.L., Lee,J.H., Blair,L.C., Ghosh-Dastidar,P., Bradshaw,R.A. and Bryan,K.M.
    Specificity of cotranslational amino-terminal processing of proteins in yeast
    Biochemistry (15-12-1987) 26, 8242-8246. PubMed  Europe PubMed
    44. 1985
  44. Tsunasawa,S., Stewart,J.W. and Sherman,F.
    Amino-terminal processing of mutant forms of yeast iso-1-cytochrome c. The specificities of methionine aminopeptidase and acetyltransferase
    J Biol Chem (1985) 260, 5382-5391. PubMed  Europe PubMed

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