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Literature for peptidase M24.017: methionyl aminopeptidase 1 (eukaryote)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, P Specificity, I Inhibitor, K Knockout, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Sun,Q., Zhao,J., Wang,G., Wang,Y., Zhu,Y., Yan,Y., Chen,Z., Chen,Z., Feng,Z. and Zuo,S.
    Isolation of OsMetAP10, a Peptidase_M24 Superfamily Gene, Regulating Heading Date in Rice
    Biology (Basel)14, PubMed  Europe PubMed DOI
    2. 2019
  2. Pillalamarri,V., Arya,T., Haque,N., Bala,S.C., Marapaka,A.K. and Addlagatta,A.
    Discovery of natural product ovalicin sensitive type 1 methionine aminopeptidases: molecular and structural basis
    Biochem J476, 991-1003. PubMed  Europe PubMed DOI
    3. 2018
  3. Jonckheere,V., Fijalkowska,D. and Van Damme,P.
    Omics assisted N-terminal proteoform and protein expression profiling on methionine aminopeptidase 1 (MetAP1) deletion
    Mol Cell Proteomics17, 694-708. PubMed  Europe PubMed DOI  K
    4. 2015
  4. Kang,J.M., Ju,J.W., Kim,J.Y., Ju,H.L., Lee,J., Lee,K.H., Lee,W.J., Sohn,W.M., Kim,T.S. and Na,B.K.
    Expression and biochemical characterization of a type I methionine aminopeptidase of Plasmodium vivax
    Protein Expr Purif108C, 48-53. PubMed  Europe PubMed DOI  E
  5. Marschner,A. and Klein,C.D.
    Metal promiscuity and metal-dependent substrate preferences of Trypanosoma brucei methionine aminopeptidase 1
    Biochimie115, 35-43. PubMed  Europe PubMed DOI
  6. Rachineni,K., Arya,T., Singarapu,K.K., Addlagatta,A. and Bharatam,J.
    Chemical shift assignments of zinc finger domain of methionine aminopeptidase 1 (MetAP1) from Homo sapiens
    Biomol NMR Assign9, 351-353. PubMed  Europe PubMed DOI
    7. 2014
  7. Reddi,R., Arya,T., Kishor,C., Gumpena,R., Ganji,R.J., Bhukya,S. and Addlagatta,A.
    Selective targeting of the conserved active site cysteine of Mycobacterium tuberculosis methionine aminopeptidase with electrophilic reagents
    FEBS J281, 4240-4248. PubMed  Europe PubMed DOI
    8. 2013
  8. Zhang,F., Bhat,S., Gabelli,S.B., Chen,X., Miller,M.S., Nacev,B.A., Cheng,Y.L., Meyers,D.J., Tenney,K., Shim,J.S., Crews,P., Amzel,L.M., Ma,D. and Liu,J.O.
    Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells
    J Med Chem56, 3996-4016. PubMed  Europe PubMed DOI  I
  9. Zhang,P., Yang,X., Zhang,F., Gabelli,S.B., Wang,R., Zhang,Y., Bhat,S., Chen,X., Furlani,M., Amzel,L.M., Liu,J.O. and Ma,D.
    Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1
    Bioorg Med Chem21, 2600-2617. PubMed  Europe PubMed DOI  I
    10. 2012
  10. Xu,W., Lu,J.P. and Ye,Q.Z.
    Structural analysis of bengamide derivatives as inhibitors of methionine aminopeptidases
    J Med Chem55, 8021-8027. PubMed  Europe PubMed DOI  I
    11. 2011
  11. Shapiro,A.B., Gao,N., Thresher,J., Walkup,G.K. and Whiteaker,J.
    A high-throughput absorbance-based assay for methionine produced by methionine aminopeptidase using S-adenosyl-L-methionine synthetase
    J Biomol Screen16, 494-505. PubMed  Europe PubMed DOI  A
    12. 2010
  12. Altmeyer,M.A., Marschner,A., Schiffmann,R. and Klein,C.D.
    Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors
    Bioorg Med Chem Lett20, 4038-4044. PubMed  Europe PubMed DOI  I
    13. 2008
  13. Haldar,M.K., Scott,M.D., Sule,N., Srivastava,D.K. and Mallik,S.
    Synthesis of barbiturate-based methionine aminopeptidase-1 inhibitors
    Bioorg Med Chem Lett18, 2373-2376. PubMed  Europe PubMed DOI  I
    14. 2006
  14. Addlagatta,A. and Matthews,B.W.
    Structure of the angiogenesis inhibitor ovalicin bound to its noncognate target, human Type 1 methionine aminopeptidase
    Protein Sci15, 1842-1848. PubMed  Europe PubMed DOI  S  I
  15. Hu,X., Addlagatta,A., Lu,J., Matthews,B.W. and Liu,J.O.
    Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression
    Proc Natl Acad Sci U S A103, 18148-18153. PubMed  Europe PubMed DOI
  16. Hu,X., Addlagatta,A., Matthews,B.W. and Liu,J.O.
    Identification of pyridinylpyrimidines as inhibitors of human methionine aminopeptidases
    Angew Chem Int Ed Engl45, 3772-3775. PubMed  Europe PubMed DOI  S  I
    17. 2005
  17. Addlagatta,A., Hu,X., Liu,J.O. and Matthews,B.W.
    Structural basis for the functional differences between type I and type II human methionine aminopeptidases
    Biochemistry44, 14741-14749. PubMed  Europe PubMed DOI  S  I
    18. 2004
  18. Bradshaw,R.A., Yi,E. and Walker,K.W.
    Methionyl aminopeptidase type I
    [ISSN:0-12-079610-4]2, 911-917.  V
  19. Giglione,C., Boularot,A. and Meinnel,T.
    Protein N-terminal methionine excision
    Cell Mol Life Sci61, 1455-1474. PubMed  Europe PubMed DOI
  20. [YEAR:5-1-2004]Hu,X., Zhu,J., Srivathsan,S. and Pei,D.
    Peptidyl hydroxamic acids as methionine aminopeptidase inhibitors
    Bioorg Med Chem Lett14, 77-79. PubMed  Europe PubMed DOI  I
  21. [YEAR:14-5-2004]Li,J.Y., Cui,Y.M., Chen,L.L., Gu,M., Li,J., Nan,F.J. and Ye,Q.Z.
    Mutations at the S1 sites of methionine aminopeptidases from Escherichia coli and Homo sapiens reveal the residues critical for substrate specificity
    J Biol Chem279, 21128-21134. PubMed  Europe PubMed DOI  P
  22. [YEAR:22-6-2004]Li,J.Y., Chen,L.L., Cui,Y.M., Luo,Q.L., Gu,M., Nan,F.J. and Ye,Q.Z.
    Characterization of full length and truncated type I human methionine aminopeptidases expressed from Escherichia coli
    Biochemistry43, 7892-7898. PubMed  Europe PubMed DOI
    23. 2003
  23. [YEAR:19-6-2003]Luo,Q.L., Li,J.Y., Liu,Z.Y., Chen,L.L., Li,J., Qian,Z., Shen,Q., Li,Y., Lushington,G.H., Ye,Q.Z. and Nan,F.J.
    Discovery and structural modification of inhibitors of methionine aminopeptidases from Escherichia coli and Saccharomyces cerevisiae
    J Med Chem46, 2631-2640. PubMed  Europe PubMed DOI  I
  24. [YEAR:26-12-2003]Towbin,H., Bair,K.W., DeCaprio,J.A., Eck,M.J., Kim,S., Kinder,F.R., Morollo,A., Mueller,D.R., Schindler,P., Song,H.K., van Oostrum,J., Versace,R.W., Voshol,H., Wood,J., Zabludoff,S. and Phillips,P.E.
    Proteomics-based target identification: bengamides as a new class of methionine aminopeptidase inhibitors
    J Biol Chem278, 52964-52971. PubMed  Europe PubMed DOI  I
    25. 2002
  25. [YEAR:1-2-2002]Chen,S., Vetro,J.A. and Chang,Y.H.
    The specificity in vivo of two distinct methionine aminopeptidases in Saccharomyces cerevisiae
    Arch Biochem Biophys398, 87-93. PubMed  Europe PubMed DOI
  26. Vetro,J.A. and Chang,Y.H.
    Yeast methionine aminopeptidase type 1 is ribosome-associated and requires its N-terminal zinc finger domain for normal function in vivo
    J Cell Biochem85, 678-688. PubMed  Europe PubMed DOI
    27. 2000
  27. Datta,B.
    MAPs and POEP of the roads from prokaryotic to eukaryotic kingdoms
    Biochimie82, 95-107. PubMed  Europe PubMed DOI  V
  28. [YEAR:7-3-2000]Lowther,W.T. and Matthews,B.W.
    Structure and function of the methionine aminopeptidases
    Biochim Biophys Acta1477, 157-167. PubMed  Europe PubMed DOI  S  I
  29. [YEAR:10-4-2000]Zhou,Y., Guo,X.C., Yi,T., Yoshimoto,T. and Pei,D.
    Two continuous spectrophotometric assays for methionine aminopeptidase
    Anal Biochem280, 159-165. PubMed  Europe PubMed DOI  A
    30. 1999
  30. [YEAR:7-5-1999]Walker,K.W. and Bradshaw,R.A.
    Yeast methionine aminopeptidase I. Alteration of substrate specificity by site-directed mutagenesis
    J Biol Chem274, 13403-13409. PubMed  Europe PubMed DOI  E
  31. Walker,K.W., Yi,E. and Bradshaw,R.A.
    Yeast (Saccharomyces cerevisiae) methionine aminopeptidase I: rapid purification and improved activity assay
    Biotechnol Appl Biochem29, 157-163. PubMed  Europe PubMed  A
    32. 1998
  32. Walker,K.W. and Bradshaw,R.A.
    Yeast methionine aminopeptidase I can utilize either Zn2+ or Co2+ as a cofactor: a case of mistaken identity?
    Protein Sci7, 2684-2687. PubMed  Europe PubMed DOI
    33. 1997
  33. [YEAR:15-11-1997]Klinkenberg,M., Ling,C. and Chang,Y.H.
    A dominant negative mutation in Saccharomyces cerevisiae methionine aminopeptidase-1 affects catalysis and interferes with the function of methionine aminopeptidase-2
    Arch Biochem Biophys347, 193-200. PubMed  Europe PubMed DOI
    34. 1996
  34. Keeling,P.J. and Doolittle,W.F.
    Methionine aminopeptidase-1: the MAP of the mitochondrion?
    Trends Biochem Sci21, 285-286. PubMed  Europe PubMed
    35. 1995
  35. Arfin,S.M., Kendall,R.L., Hall,L., Weaver,L.H., Stewart,A.E., Matthews,B.W. and Bradshaw,R.A.
    Eukaryotic methionyl aminopeptidases: two classes of cobalt-dependent enzymes
    Proc Natl Acad Sci U S A92, 7714-7718. PubMed  Europe PubMed DOI
  36. Li,X. and Chang,Y.H.
    Amino-terminal protein processing in Saccharomyces cerevisiae is an essential function that requires two distinct methionine aminopeptidases
    Proc Natl Acad Sci U S A92, 12357-12361. PubMed  Europe PubMed DOI
  37. Zuo,S., Guo,Q., Ling,C. and Chang,Y.H.
    Evidence that two zinc fingers in the methionine aminopeptidase from Saccharomyces cerevisiae are important for normal growth
    Mol Gen Genet246, 247-253. PubMed  Europe PubMed DOI
    38. 1992
  38. Chang,Y.H., Teichert,U. and Smith,J.A.
    Molecular cloning, sequencing, deletion, and overexpression of a methionine aminopeptidase gene from Saccharomyces cerevisiae
    J Biol Chem267, 8007-8011. PubMed  Europe PubMed
    39. 1990
  39. [YEAR:15-11-1990]Chang,Y.H., Teichert,U. and Smith,J.A.
    Purification and characterization of a methionine aminopeptidase from Saccharomyces cerevisiae
    J Biol Chem265, 19892-19897. PubMed  Europe PubMed
  40. [YEAR:15-11-1990]Moerschell,R.P., Hosokawa,Y., Tsunasawa,S. and Sherman,F.
    The specificities of yeast methionine aminopeptidase and acetylation of amino-terminal methionine in vivo. Processing of altered iso-1-cytochromes c created by oligonucleotide transformation
    J Biol Chem265, 19638-19643. PubMed  Europe PubMed
    41. 1988
  41. [YEAR:15-6-1988]Boissel,J.P., Kasper,T.J. and Bunn,H.F.
    Cotranslational amino-terminal processing of cytosolic proteins. Cell-free expression of site-directed mutants of human hemoglobin
    J Biol Chem263, 8443-8449. PubMed  Europe PubMed
    42. 1987
  42. [YEAR:15-12-1987]Huang,S., Elliott,R.C., Liu,P.S., Koduri,R.K., Weickmann,J.L., Lee,J.H., Blair,L.C., Ghosh-Dastidar,P., Bradshaw,R.A. and Bryan,K.M.
    Specificity of cotranslational amino-terminal processing of proteins in yeast
    Biochemistry26, 8242-8246. PubMed  Europe PubMed
    43. 1985
  43. Tsunasawa,S., Stewart,J.W. and Sherman,F.
    Amino-terminal processing of mutant forms of yeast iso-1-cytochrome c. The specificities of methionine aminopeptidase and acetyltransferase
    J Biol Chem260, 5382-5391. PubMed  Europe PubMed

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