$VAR1 = undef;

Summary for peptidase M16.005: nardilysin

Names
MEROPS Name	nardilysin
Other names	N-arginine dibasic convertase, NRDC g.p. (Homo sapiens), NRD-convertase, somatostatin-28 convertase, HGNC:7995

Domain architecture

MEROPS Classification
Classification	Clan ME >> Subclan (none) >> Family M16 >> Subfamily A >> M16.005
Holotype	nardilysin (Rattus norvegicus), Uniprot accession P47245 (peptidase unit: 222-428), MERNUM MER0001220
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00223
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.61
Enzymology	BRENDA database
Proteolytic events	CutDB database (1 cleavage)
Activity status	human: active (Chesneau et al., 2004) mouse: active (Ma et al., 2002)
Physiology	Nardilysin is reported to contain a bipartite nuclear localization signal that permits the enzyme to cycle between the nucleus and cytoplasm (Ma et al., 2005).
Other databases	TREEFAM	http://www.treefam.org/family/TF106274