Substrates for peptidase M14.002: carboxypeptidase A2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
carboxypeptidase A2	P48052	19-97	peptide-Val97+	P	MS	Asp	Val	Gln	Val	Leu	'-'	'-'	'-'	Szmola et al., 2011
carboxypeptidase A2	P48052	19-96	peptide-Gln96+	P	MS	Glu	Asp	Val	Gln	Val	'-'	'-'	'-'	Szmola et al., 2011
furylacryloyl-Phe-Ile			furylacryloyl-Phe+Ile	S		-	-	FA	Phe	Ile	-	-	-	Tanco et al., 2010
furylacryloyl-Phe-Leu			furylacryloyl-Phe+Leu	S		-	-	FA	Phe	Leu	-	-	-	Tanco et al., 2010
furylacryloyl-Phe-Phe (FAPP)			furylacryloyl-Phe+Phe	S		-	-	FA	Phe	Phe	-	-	-	Tanco et al., 2010
furylacryloyl-Phe-Trp			furylacryloyl-Phe+Trp	S		-	-	FA	Phe	Trp	-	-	-	Tanco et al., 2010
N-(4-methoxyphenyl-azoformyl)-Phe-OH			N-(4-methoxyphenyl-azoformyl)+Phe-OH	S		-	-	-	MFA	Phe	-	-	-	Pallares et al., 2005
Z-Gly-Gly-Leu			Z-Gly-Gly+Leu	S		-	Z	Gly	Gly	Leu	-	-	-	Auld, 2004
Z-Gly-Gly-Phe			Z-Gly-Gly+Phe	S		-	Z	Gly	Gly	Phe	-	-	-	Auld, 2004
Z-Gly-Gly-Trp			Z-Gly-Gly+Trp	S		-	Z	Gly	Gly	Trp	-	-	-	Auld, 2004
Z-Gly-Trp			Z-Gly+Trp	S		-	-	Z	Gly	Trp	-	-	-	Auld, 2004