Substrates for peptidase M12.310: metallopeptidase MTP-1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Hemoglobin subunit alpha	P60529	1-141	Val-Leu2+Ser-Peptide	N	MS	-	-	Val	Leu	Ser	Pro	Ala	Asp	Williamson et al., 2004
Hemoglobin subunit alpha	P60529	1-141	Peptide-His20+Ala-Peptide	N	MS	Ile	Gly	Gly	His	Ala	Gly	Asp	Tyr	Williamson et al., 2004
Hemoglobin subunit alpha	P60529	1-141	Peptide-Asp64+Ala-Peptide	N	MS	Lys	Val	Ala	Asp	Ala	Leu	Thr	Thr	Williamson et al., 2004
Hemoglobin subunit alpha	P60529	1-141	Peptide-Asp75+Leu-Peptide	N	MS	His	Leu	Asp	Asp	Leu	Pro	Gly	Ala	Williamson et al., 2004
Hemoglobin subunit alpha	P60529	1-141	Peptide-Leu80+Ser-Peptide	N	MS	Pro	Gly	Ala	Leu	Ser	Ala	Leu	Ser	Williamson et al., 2004
Hemoglobin subunit alpha	P60529	1-141	Peptide-Arg92+Val-Peptide	N	MS	Tyr	Lys	Leu	Arg	Val	Asp	Pro	Val	Williamson et al., 2004
Hemoglobin subunit alpha	P60529	1-141	Peptide-Asp94+Pro-Peptide	N	MS	Leu	Arg	Val	Asp	Pro	Val	Asn	Phe	Williamson et al., 2004
Hemoglobin subunit alpha	P60529	1-141	Peptide-Lys99+Leu-Peptide	N	MS	Val	Asn	Phe	Lys	Leu	Leu	Ser	His	Williamson et al., 2004
Hemoglobin subunit alpha	P60529	1-141	Peptide-Cys111+His-Peptide	N	MS	Thr	Leu	Ala	Cys	His	His	Pro	Thr	Williamson et al., 2004
Hemoglobin subunit alpha	P60529	1-141	Peptide-Pro119+Ala-Peptide	N	MS	Glu	Phe	Thr	Pro	Ala	Val	His	Ala	Williamson et al., 2004
Hemoglobin subunit beta	P60524	1-146	Val-His2+Leu-Peptide	N	MS	-	-	Val	His	Leu	Thr	Ala	Glu	Williamson et al., 2004
Hemoglobin subunit beta	P60524	1-146	Peptide-Gly13+Leu-Peptide	N	MS	Leu	Val	Ser	Gly	Leu	Trp	Gly	Lys	Williamson et al., 2004
Hemoglobin subunit beta	P60524	1-146	Peptide-Asp47+Leu-Peptide	N	MS	Ser	Phe	Gly	Asp	Leu	Ser	Thr	Pro	Williamson et al., 2004
Hemoglobin subunit beta	P60524	1-146	Peptide-Lys76+Asn-Peptide	N	MS	Asp	Gly	Leu	Lys	Asn	Leu	Asp	Asn	Williamson et al., 2004
Hemoglobin subunit beta	P60524	1-146	Peptide-Asn77+Leu-Peptide	N	MS	Gly	Leu	Lys	Asn	Leu	Asp	Asn	Leu	Williamson et al., 2004
Hemoglobin subunit beta	P60524	1-146	Peptide-Leu105+Leu-Peptide	N	MS	Asn	Phe	Lys	Leu	Leu	Gly	Asn	Val	Williamson et al., 2004
Hemoglobin subunit beta	P60524	1-146	Peptide-Ala128+Ala-Peptide	N	MS	Gln	Val	Gln	Ala	Ala	Tyr	Gln	Lys	Williamson et al., 2004
Hemoglobin subunit beta	P60524	1-146	Peptide-Ala135+Gly-Peptide	N	MS	Lys	Val	Val	Ala	Gly	Val	Ala	Asn	Williamson et al., 2004