Sequence features for peptidase M12.244: ADAM33 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

 

MERNUM Species Sequence length Peptidase unit Active site residues Metal ligands Source
MER1218686 Acinonyx jubatus 599 191-326 missing H326, missing, missing GENBANK:XP_014933615
MER1217353 Ailuropoda melanoleuca 817 196-395 E332 H331, H335, H341 GENBANK:XP_019654746
MER1217763 Aotus nancymaae 939 346-545 E482 H481, H485, H491 GENBANK:XP_021521476
MER0409558 Balaenoptera acutorostrata 780 209-408 E347 H346, H350, H356 GENBANK:XP_007195913
MER0679315 Bison bison 809 208-303 missing missing, missing, missing GENBANK:XP_010834929
MER0341793 Bos grunniens 810 213-411 E349 H348, H352, H358 UNIPROT:L8IM72
MER0341793 Bos grunniens 810 213-411 E349 H348, H352, H358 UNIPROT:L8IM72
MER1217399 Bos grunniens 858 279-478 E415 H414, H418, H424 GENBANK:XP_014333121
MER1217837 Bos indicus 790 211-410 E347 H346, H350, X356 GENBANK:XP_019827494
MER0188221 Bos taurus 987 408-607 E544 H543, H547, H553 GENBANK:XP_601929
MER0580945 Bubalus bubalis 899 317-517 E456 H455, H459, H465 GENBANK:XP_006072969
MER0580948 Bubalus bubalis 790 208-408 E347 H346, H350, H356 GENBANK:XP_006072971
MER0357165 Callithrix jacchus 1035 389-588 E525 H524, H528, H534 GENBANK:XP_002747454
MER1217497 Callithrix jacchus 845 196-395 E332 H331, H335, H341 GENBANK:XP_017827418
MER1217570 Camelus bactrianus 723 124-323 E260 H259, H263, H269 GENBANK:XP_010971069
MER1217573 Camelus bactrianus 825 226-425 E362 H361, H365, H371 GENBANK:XP_010971059
MER0677574 Camelus dromedarius 825 223-423 E362 H361, H365, H371 GENBANK:XP_010986556
MER0677577 Camelus dromedarius 723 121-321 E260 H259, H263, H269 GENBANK:XP_010986568
MER0677578 Camelus dromedarius 824 222-422 E361 H360, H364, H370 GENBANK:XP_010986557
MER0677579 Camelus dromedarius 760 158-358 E297 H296, H300, H306 GENBANK:XP_010986565
MER0677580 Camelus dromedarius 821 223-423 E362 H361, H365, H371 GENBANK:XP_010986558
MER0524913 Camelus ferus 834 210-405 E344 H343, H347, H353 GENBANK:XP_006187196
MER1220465 Camelus ferus 807 213-407 E344, H343, H347, H353, GENBANK:XP_014416756
MER0077777 Canis lupus familiaris 878 305-508 E445 H444, H448, H454 GENBANK:XP_542918
MER0602941 Canis lupus familiaris 888 331-506 E445 H444, H448, H454 GENBANK:XP_005634891
MER1218473 Canis lupus familiaris 887 280-507 E444 H443, H447, H453 GENBANK:XP_022264644
MER0533261 Capra hircus 638 198-354 E337 H336, H340, H346 GENBANK:XP_005688292
MER1217540 Capra hircus 740 75-274 E211 H210, H214, H220 GENBANK:XP_017912898
MER1217541 Capra hircus 817 211-410 E347 H346, H350, H356 GENBANK:XP_017912896
MER1217544 Capra hircus 849 211-410 E347 H346, H350, H356 GENBANK:XP_017912895
MER1217545 Capra hircus 850 211-410 E347 H346, H350, H356 GENBANK:XP_017912894
MER1217546 Capra hircus 875 210-409 E346 H345, H349, H355 GENBANK:XP_017912893
MER1217547 Capra hircus 875 211-410 E347 H346, H350, H356 GENBANK:XP_017912892
MER1217548 Capra hircus 876 211-410 E347 H346, H350, H356 GENBANK:XP_017912890
MER1217778 Castor canadensis 832 212-410 E347 H346, H350, H356 GENBANK:XP_020032148
MER0186833 Cavia porcellus 918 340-535 E476 H475, H479, H485 GENBANK:XP_003476460
MER1217472 Cavia porcellus 790 212-407 E348 H347, H351, H357 GENBANK:XP_013015243
MER1217613 Cebus capucinus 805 198-397 E334 H333, H337, H343 GENBANK:XP_017360300
MER0397998 Ceratotherium simum 781 209-410 E348 H347, H351, H357 GENBANK:XP_004433930
MER1217458 Ceratotherium simum 841 212-411 E348 H347, H351, H357 GENBANK:XP_014645592
MER1217398 Cercocebus atys 812 209-409 E346 H345, H349, H355 GENBANK:XP_011907598
MER0584741 Cercopithecus sabaeus 809 208-404 E343 H342, H346, H352 GENBANK:XP_008017839
MER1217056 Cervus elaphus 247 14-177 E150 H149, H153, H159 GENBANK:OWK03403
MER0584309 Chinchilla lanigera 805 210-406 E349 H348, H352, H358 GENBANK:XP_005380853
MER1217463 Chinchilla lanigera 873 212-407 E348 H347, H351, H357 GENBANK:XP_013367582
MER0575244 Chrysochloris asiatica 790 195-388 E327 H326, H330, H336 GENBANK:XP_006874915
MER0669752 Colobus angolensis 812 207-407 E346 H345, H349, H355 GENBANK:XP_011798695
MER0574170 Condylura cristata 861 213-415 E353 H352, H356, H362 GENBANK:XP_004687062
MER1217483 Condylura cristata 747 183-381 E318 H317, H321, H327 GENBANK:XP_012583526
MER0186807 Cricetulus griseus 986 398-597 E534 H533, H537, H543 GENBANK:XP_003499098
MER1217493 Cricetulus griseus 794 207-406 E343 H342, H346, H352 GENBANK:XP_016829053
MER1217428 Delphinapterus leucas 786 211-410 E347 H346, H350, H356 GENBANK:XP_022448596
MER1218366 Delphinapterus leucas 778 211-402 E339 H338, H342, H348 GENBANK:XP_022448598
MER1217704 Dipodomys ordii 776 198-394 E333 H332, H336, H342 GENBANK:XP_012866215
MER0107016 Echinops telfairi 767 203-402 E339 H338, H342, H348 GENBANK:XP_004698231
MER0565626 Elephantulus edwardii 801 221-422 E361 H360, H364, H370 GENBANK:XP_006894320
MER1217539 Enhydra lutris 852 212-411 E348 H347, H351, H357 GENBANK:XP_022350232
MER0563627 Eptesicus fuscus 782 212-414 E352 H351, H355, H361 GENBANK:XP_008139496
MER1217712 Equus asinus 783 160-359 E296 H295, H299, H305 GENBANK:XP_014722589
MER1217717 Equus asinus 835 212-411 E348 H347, H351, H357 GENBANK:XP_014722583
MER0172565 Equus caballus 827 179-381 E318 H317, H321, H327 GENBANK:XP_001916051
MER1217721 Equus caballus 835 212-411 E348 H347, H351, H357 GENBANK:XP_014590539
MER1218694 Equus caballus 865 212-441 E378 H377, H381, H387 GENBANK:XP_023481951
MER0561942 Equus przewalskii 835 209-409 E348 H347, H351, H357 GENBANK:XP_008531822
MER0561945 Equus przewalskii 783 157-357 E296 H295, H299, H305 GENBANK:XP_008531827
MER0561946 Equus przewalskii 791 209-409 E348 H347, H351, H357 GENBANK:XP_008531826
MER0561949 Equus przewalskii 708 82-282 E221 H220, H224, H230 GENBANK:XP_008531830
MER0615608 Erinaceus europaeus 788 207-407 E346 H345, H349, H355 GENBANK:XP_007539652
MER0341903 Felis catus 868 299-498 E435 H434, H438, H444 GENBANK:XP_003983756
MER0657050 Fukomys damarensis 803 210-376 E349 H348, H352, H358 GENBANK:XP_010609354
MER0829740 Fukomys damarensis 787 177-299 E284 H283, H287, H293 UNIPROT:A0A091CRS9
MER0829740 Fukomys damarensis 787 177-299 E284 H283, H287, H293 UNIPROT:A0A091CRS9
MER1217678 Fukomys damarensis 783 212-367 E349 H348, H352, H358 GENBANK:XP_019061103
MER0557216 Galeopterus variegatus 822 252-441 E380 H379, H383, H389 GENBANK:XP_008585502
MER0342014 Gorilla gorilla 882 279-478 E415 H414, H418, H424 GENBANK:XP_004061783
MER1217694 Gorilla gorilla 812 210-409 E346 H345, H349, H355 GENBANK:XP_018873077
MER0186962 Heterocephalus glaber 839 204-411 E348 H347, H351, H357 UNIPROT:G5B4U2
MER0186962 Heterocephalus glaber 839 204-411 E348 H347, H351, H357 UNIPROT:G5B4U2
MER1217445 Heterocephalus glaber 1038 212-412 E349 H348, H352, H358 GENBANK:XP_012926156
MER1218612 Heterocephalus glaber 1016 199-390 E327 H326, H330, H336 GENBANK:XP_021110655
MER1217882 Hipposideros armiger 795 212-410 E347 H346, H350, H356 GENBANK:XP_019500118
MER0015143 Homo sapiens 813 206-409 E346 H345, H349, H355 GENBANK:XP_016883571
MER0015143 Homo sapiens 813 206-409 E346 H345, H349, H355 GENBANK:XP_016883571
MER0015143 Homo sapiens 813 206-409 E346 H345, H349, H355 GENBANK:XP_016883571
MER0015143 Homo sapiens 813 206-409 E346 H345, H349, H355 GENBANK:XP_016883571
MER0015143 Homo sapiens 813 206-409 E346 H345, H349, H355 GENBANK:XP_016883571
MER0015143 Homo sapiens 813 206-409 E346 H345, H349, H355 GENBANK:XP_016883571
MER0015143 Homo sapiens 813 206-409 E346 H345, H349, H355 GENBANK:XP_016883571
MER0106601 Ictidomys tridecemlineatus 851 214-410 E349 H348, H352, H358 GENBANK:XP_005320675
MER1217956 Ictidomys tridecemlineatus 805 213-412 E349 H348, H352, H358 GENBANK:XP_013211883
MER0547701 Jaculus jaculus 837 206-399 E346 H345, H349, H355 GENBANK:XP_004661498
MER0552860 Leptonychotes weddellii 784 207-408 E347 H346, H350, H356 GENBANK:XP_006742664
MER0188275 Loxodonta africana 826 181-381 E317 H316, H320, H326 GENBANK:XP_003411488
MER1218428 Loxodonta africana 786 206-406 E342 H341, H345, H351 GENBANK:XP_010589859
MER0604164 Macaca fascicularis 813 206-407 E346 H345, H349, H355 GENBANK:XP_005568507
MER1217635 Macaca fascicularis 822 210-409 E346 H345, H349, H355 GENBANK:XP_015313175
MER0829093 Macaca mulatta 812 211-362 E346 H345, H349, H355 UNIPROT:F7HP30
MER0829671 Macaca mulatta 786 211-362 E346 H345, H349, H355 UNIPROT:F6QRW9
MER0829749 Macaca mulatta 798 211-362 E346 H345, H349, H355 UNIPROT:F6QRV1
MER1217637 Macaca mulatta 857 210-409 E346 H345, H349, H355 GENBANK:XP_015004876
MER1217634 Macaca nemestrina 798 210-409 E346 H345, H349, H355 GENBANK:XP_011739573
MER0644633 Mandrillus leucophaeus 812 211-407 E346 H345, H349, H355 GENBANK:XP_011830338
MER1217206 Manis javanica 808 229-428 E365 H364, H368, H374 GENBANK:XP_017535600
MER1218536 Manis javanica 836 229-456 E393 H392, H396, H402 GENBANK:XP_017535593
MER1217824 Marmota marmota 805 213-412 E349 H348, H352, H358 GENBANK:XP_015343791
MER1217731 Meriones unguiculatus 735 211-410 E347 H346, H350, H356 GENBANK:XP_021483247
MER1217737 Meriones unguiculatus 862 211-410 E347 H346, H350, H356 GENBANK:XP_021483246
MER1217739 Meriones unguiculatus 931 211-410 E347 H346, H350, H356 GENBANK:XP_021483240
MER0543835 Mesocricetus auratus 803 206-402 E341 H340, H344, H350 GENBANK:XP_005068693
MER1217683 Mesocricetus auratus 780 206-404 E341 H340, H344, H350 GENBANK:XP_021082010
MER1217449 Microcebus murinus 764 207-406 E343 H342, H346, H352 GENBANK:XP_020137488
MER1217453 Microcebus murinus 779 207-406 E343 H342, H346, H352 GENBANK:XP_012610727
MER0538778 Microtus ochrogaster 806 207-404 E342 H341, H345, H351 GENBANK:XP_005365649
MER1217422 Miniopterus natalensis 742 211-374 E347 H346, H350, H356 GENBANK:XP_016067429
MER1217767 Mus caroli 797 211-374 E347 H346, H350, H356 GENBANK:XP_021011172
MER0015147 Mus musculus 797 207-410 E347 H346, H350, H356 UNIPROT:Q923W9
MER0015147 Mus musculus 797 207-410 E347 H346, H350, H356 UNIPROT:Q923W9
MER0015147 Mus musculus 797 207-410 E347 H346, H350, H356 UNIPROT:Q923W9
MER1217817 Mus musculus 661 75-225 E211 H210, H214, H220 GENBANK:XP_011237550
MER1218705 Mus musculus 784 211-348 E334 H333, H337, H343 GENBANK:XP_006498639
MER1219270 Mus musculus 413 211-363 L349 H348, R355, H361 GENBANK:XP_011237557
MER1217659 Mus pahari 794 208-371 E344 H343, H347, H353 GENBANK:XP_021048774
MER0357453 Mustela putorius 448 1-114 E51 H50, H54, H60 UNIPROT:M1EB53
MER0357453 Mustela putorius 448 1-114 E51 H50, H54, H60 UNIPROT:M1EB53
MER0568273 Myotis brandtii 784 219-364 E359 H358, H362, missing GENBANK:XP_005874815
MER1218546 Myotis brandtii 672 211-371 E347 H346, H350, P359 GENBANK:XP_014402013
MER1220460 Myotis brandtii 534 139-258 missing missing, missing, missing GENBANK:EPQ12995
MER0342586 Myotis davidii 511 106-308 E272 H271, H275, H281 UNIPROT:L5M832
MER0342586 Myotis davidii 511 106-308 E272 H271, H275, H281 UNIPROT:L5M832
MER0614002 Myotis davidii 690 209-381 E349 H348, H352, H358 GENBANK:XP_006758188
MER1217945 Myotis davidii 724 213-384 E349 H348, H352, H358 GENBANK:XP_015415705
MER0185566 Myotis lucifugus 732 176-377 E316 H315, H319, H325 GENBANK:XP_006096514
MER0829627 Myotis lucifugus 750 195-348 E331 H330, H334, H340 GENBANK:-
MER1217016 Myotis lucifugus 729 196-399 E336 H335, H339, H345 GENBANK:XP_023616074
MER0642031 Nannospalax galili 135 3-30 missing missing, missing, missing GENBANK:XP_008824612
MER0642038 Nannospalax galili 266 95-266 E235 H234, H238, H244 GENBANK:XP_008824708
MER1217117 Nannospalax galili 261 86-248 E222 H221, H225, H231 GENBANK:XP_017651962
MER1217287 Neomonachus schauinslandi 784 211-410 E347 H346, H350, H356 GENBANK:XP_021544707
MER0829372 Neovison vison 287 74-226 E210 H209, H213, H219 UNIPROT:U6DH00
MER0829372 Neovison vison 287 74-226 E210 H209, H213, H219 UNIPROT:U6DH00
MER0186803 Nomascus leucogenys 813 210-409 E346 H345, H349, H355 GENBANK:XP_003278008
MER1218059 Ochotona princeps 914 333-532 E469 H468, H472, H478 GENBANK:XP_012784731
MER0532554 Octodon degus 738 207-404 E347 H346, H350, H356 GENBANK:XP_004634381
MER1217564 Octodon degus 792 210-405 E346 H345, H349, H355 GENBANK:XP_023574396
MER1218796 Octodon degus 768 210-381 E322 H321, H325, H331 GENBANK:XP_023574398
MER0530899 Odobenus rosmarus 967 384-585 E524 H523, H527, H533 GENBANK:XP_004398280
MER1217416 Odobenus rosmarus 1027 387-586 E523 H522, H526, H532 GENBANK:XP_012417055
MER1217331 Odocoileus virginianus 790 211-410 E347 H346, H350, H356 GENBANK:XP_020732727
MER1218355 Oncorhynchus mykiss 403 1-211 E148 H147, H151, H157 GENBANK:XP_021434094
MER0530287 Orcinus orca 780 209-408 E347 H346, H350, H356 GENBANK:XP_004285388
MER0527573 Orycteropus afer 793 208-404 E343 H342, H346, H352 GENBANK:XP_007932870
MER0110430 Oryctolagus cuniculus 989 453-651 E588 H587, H591, H597 GENBANK:XP_002710932
MER1217798 Oryctolagus cuniculus 725 144-342 E279 H278, H282, H288 GENBANK:XP_017197230
MER0357168 Otolemur garnettii 1220 682-882 E819 H818, H822, H828 GENBANK:XP_003788262
MER1217772 Otolemur garnettii 745 207-407 E344 H343, H347, H353 GENBANK:XP_012659524
MER1217474 Ovis ammon musimon 790 211-410 E347 H346, H350, H356 GENBANK:XP_011964673
MER0344289 Ovis aries 726 202-391 R328 H327, H331, H337 GENBANK:XP_004014771
MER1218901 Ovis aries 745 211-400 R337 H336, H340, H346 GENBANK:XP_014955211
MER0357198 Pan paniscus 810 209-406 E343 H342, H346, H352 GENBANK:XP_003821356
MER1218543 Pan paniscus 784 209-406 E343 H342, H346, H352 GENBANK:XP_014198463
MER0298998 Pan troglodytes 813 210-409 E346 H345, H349, H355 UNIPROT:K7D2R9
MER0298998 Pan troglodytes 813 210-409 E346 H345, H349, H355 UNIPROT:K7D2R9
MER0829016 Pan troglodytes 622 209-362 E346 H345, H349, H355 GENBANK:-
MER1217698 Pan troglodytes 827 210-409 E346 H345, H349, H355 GENBANK:XP_016792855
MER1218561 Pan troglodytes 853 210-435 E372 H371, H375, H381 GENBANK:XP_016792850
MER1218589 Pan troglodytes 760 201-387 E324 H323, H327, H333 GENBANK:PNI62428
MER1217526 Panthera pardus 855 260-459 E396 H395, H399, H405 GENBANK:XP_019318197
MER0518910 Panthera tigris 777 184-408 E325 H324, H328, H340 GENBANK:XP_007073331
MER1218264 Panthera tigris 675 189-352 E325 H324, H328, P340 GENBANK:XP_015390831
MER0517523 Pantholops hodgsonii 790 208-408 E347 H346, H350, H356 GENBANK:XP_005974862
MER0341994 Papio anubis 812 211-409 E346 H345, H349, H355 GENBANK:XP_003905059
MER1217675 Papio anubis 822 211-409 E346 H345, H349, H355 GENBANK:XP_017800967
MER1217555 Peromyscus maniculatus 841 211-411 E347 H346, H350, H356 GENBANK:XP_015858512
MER1218582 Peromyscus maniculatus 738 121-308 E244 H243, H247, H253 GENBANK:XP_015858517
MER1217672 Piliocolobus tephrosceles 798 211-409 E346 H345, H349, H355 GENBANK:XP_023076006
MER0185909 Pongo abelii 813 210-409 E346 H345, H349, H355 UNIPROT:H2P1C2
MER0185909 Pongo abelii 813 210-409 E346 H345, H349, H355 UNIPROT:H2P1C2
MER1217645 Pongo abelii 666 214-413 E350 H349, H353, H359 GENBANK:PNJ14024
MER1217652 Pongo abelii 812 210-409 E346 H345, H349, H355 GENBANK:XP_009231681
MER1218555 Pongo abelii 760 196-387 E324 H323, H327, H333 GENBANK:PNJ14025
MER0342591 Pteropus alecto 677 203-340 E326 H325, H329, H335 UNIPROT:L5K0J3
MER0342591 Pteropus alecto 677 203-340 E326 H325, H329, H335 UNIPROT:L5K0J3
MER1217410 Pteropus alecto 791 211-411 E348 H347, H351, H357 GENBANK:XP_015452434
MER1217424 Pteropus vampyrus 790 210-410 E347 H346, H350, H356 GENBANK:XP_023392958
MER0026936 Rattus norvegicus 780 213-410 E349 H348, H352, H358 GENBANK:XP_003753819
MER1217734 Rattus norvegicus 809 213-410 E349 H348, H352, H358 GENBANK:XP_017456644
MER1217516 Rhinolophus sinicus 809 212-410 E347 H346, H350, H356 GENBANK:XP_019589408
MER1218445 Rhinolophus sinicus 835 250-436 E373 H372, H376, H382 GENBANK:XP_019589405
MER1217735 Rhinopithecus bieti 745 158-356 E293 H292, H296, H302 GENBANK:XP_017728121
MER1217750 Rhinopithecus bieti 834 247-445 E382 H381, H385, H391 GENBANK:XP_017728111
MER0558389 Rhinopithecus roxellana 813 206-407 E346 H345, H349, H355 GENBANK:XP_010377267
MER1217733 Rousettus aegyptiacus 765 134-334 E271 H270, H274, H280 GENBANK:XP_015995428
MER1217756 Rousettus aegyptiacus 803 223-423 E360 H359, H363, H369 GENBANK:XP_015995289
MER1217759 Rousettus aegyptiacus 854 223-423 E360 H359, H363, H369 GENBANK:XP_015994970
MER1218602 Rousettus aegyptiacus 709 223-449 E386 H385, H389, H395 GENBANK:XP_015995484
MER1218605 Rousettus aegyptiacus 791 134-360 E297 H296, H300, H306 GENBANK:XP_015995370
MER1218606 Rousettus aegyptiacus 814 157-383 E320 H319, H323, H329 GENBANK:XP_015995193
MER1218607 Rousettus aegyptiacus 829 223-449 E386 H385, H389, H395 GENBANK:XP_015995110
MER1218610 Rousettus aegyptiacus 880 223-449 E386 H385, H389, H395 GENBANK:XP_015994685
MER0511865 Saimiri boliviensis 723 289-317 missing missing, missing, missing GENBANK:XP_003941163
MER0104924 Sorex araneus 773 248-437 E376 H375, H379, H385 GENBANK:XP_004611048
MER0186935 Sus scrofa 896 260-459 E396 H395, H399, H405 GENBANK:XP_003483962
MER0829501 Sus scrofa 804 219-379 E354 H353, H357, H363 GENBANK:-
MER1217345 Sus scrofa 803 224-423 E360 H359, H363, H369 GENBANK:XP_020933045
MER0595834 Tarsius syrichta 726 222-306 E245 H244, H248, H254 GENBANK:XP_008064756
MER0480334 Trichechus manatus 948 206-406 E345 H344, H348, H354 GENBANK:XP_004383128
MER0346397 Tupaia chinensis 954 211-303 missing missing, missing, missing UNIPROT:L8YEK4
MER0346397 Tupaia chinensis 954 211-303 missing missing, missing, missing UNIPROT:L8YEK4
MER1217523 Tursiops truncatus 715 146-345 E282 H281, H285, H291 GENBANK:XP_019806176
MER0112605 Ursus maritimus 782 202-365 E334 H333, H337, H343 GENBANK:XP_008701662
MER0616346 Vicugna pacos 782 210-410 E349 H348, H352, H358 GENBANK:XP_006207475
MER1217591 Vicugna pacos 723 124-323 E260 H259, H263, H269 GENBANK:XP_015097319
MER1217598 Vicugna pacos 760 161-360 E297 H296, H300, H306 GENBANK:XP_015097316
MER1217602 Vicugna pacos 825 226-425 E362 H361, H365, H371 GENBANK:XP_015097305