Sequence features for peptidase M12.226: ADAMTS8 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

 

MERNUM Species Sequence length Peptidase unit Active site residues Metal ligands Source
MER0690104 Acanthisitta chloris 621 1-101 E43 H42, H46, H52 GENBANK:XP_009075006
MER0269004 Ailuropoda melanoleuca 818 148-310 E293 H292, H296, H302 GENBANK:XP_002912743
MER0291142 Alligator mississippiensis 703 1-190 E125 H124, H128, H134 GENBANK:XP_006262152
MER0304127 Alligator sinensis 711 1-198 E133 H132, H136, H142 GENBANK:XP_006033316
MER0300471 Anas platyrhynchos 832 39-228 E163 H162, H166, H172 GENBANK:XP_005031995
MER0226100 Anolis carolinensis 931 203-412 E347 H346, H350, H356 GENBANK:XP_003223216
MER0687484 Aptenodytes forsteri 755 11-198 E138 H137, H141, H147 GENBANK:XP_009271278
MER0686439 Aquila chrysaetos 913 186-395 E335 H334, H338, H344 GENBANK:XP_011587710
MER0555762 Astatotilapia burtoni 943 213-427 E362 H361, H365, H371 GENBANK:XP_005937474
MER0362154 Astyanax mexicanus 913 184-398 E333 H332, H336, H342 GENBANK:XP_007260551
MER0378852 Astyanax mexicanus 900 275-489 E424 H423, H427, H433 GENBANK:XP_007231113
MER0829048 Astyanax mexicanus 914 201-357 E342 H341, H345, H351 GENBANK:-
MER1221387 Astyanax mexicanus 1012 280-489 E424, H423, H427, H433, GENBANK:XP_022530107
MER0400836 Balaenoptera acutorostrata 659 1-185 E134 H133, H137, H143 GENBANK:XP_007183401
MER0679726 Bison bison 911 238-453 E388 H387, H391, H397 GENBANK:XP_010843025
MER0346785 Bos grunniens 830 173-384 E319 H318, H322, H328 UNIPROT:L8J438
MER0346785 Bos grunniens 830 173-384 E319 H318, H322, H328 UNIPROT:L8J438
MER0078021 Bos taurus 899 231-441 E376 H375, H379, H385 UNIPROT:F1MP11
MER0078021 Bos taurus 899 231-441 E376 H375, H379, H385 UNIPROT:F1MP11
MER0581479 Bubalus bubalis 875 202-417 E352 H351, H355, H361 GENBANK:XP_006061807
MER0678152 Buceros rhinoceros 627 1-183 E123 H122, H126, H132 GENBANK:XP_010134391
MER0357749 Callithrix jacchus 891 221-431 E366 H365, H369, H375 UNIPROT:F7HYD2
MER0357749 Callithrix jacchus 891 221-431 E366 H365, H369, H375 UNIPROT:F7HYD2
MER0828982 Callithrix jacchus 844 176-335 E319 H318, H322, H328 GENBANK:-
MER0581671 Calypte anna 764 36-245 E185 H184, H188, H194 GENBANK:XP_008496702
MER0677519 Camelus dromedarius 603 1-139 E134 H133, D137, missing GENBANK:XP_010984589
MER0353933 Camelus ferus 806 131-346 E281 H280, H284, H290 GENBANK:XP_006181794
MER0828994 Camelus ferus 626 12-116 E101 H100, H104, H110 UNIPROT:T0MFI6
MER0828994 Camelus ferus 626 12-116 E101 H100, H104, H110 UNIPROT:T0MFI6
MER0357751 Canis lupus familiaris 1040 370-580 E515 H514, H518, H524 GENBANK:XP_003434589
MER0522204 Capra hircus 759 86-301 E236 H235, H239, H245 GENBANK:XP_005699784
MER0674832 Cariama cristata 708 39-224 E159 H158, H162, H168 GENBANK:XP_009701607
MER0828892 Castor fiber 909 241-399 E384 H383, H387, H393 UNIPROT:A0A0B5CYU2
MER0828892 Castor fiber 909 241-399 E384 H383, H387, H393 UNIPROT:A0A0B5CYU2
MER0541453 Ceratotherium simum 846 171-372 E321 H320, H324, H330 GENBANK:XP_004438570
MER0584674 Cercopithecus sabaeus 888 213-414 E363 H362, H366, H372 GENBANK:XP_008019721
MER0673343 Chaetura pelagica 654 9-216 E158 H157, H161, H167 GENBANK:XP_010001189
MER0672137 Charadrius vociferus 712 12-192 E134 H133, H137, H143 GENBANK:XP_009889128
MER0592000 Chelonia mydas 711 1-198 E133 H132, H136, H142 GENBANK:XP_007068656
MER0584151 Chinchilla lanigera 967 334-532 E481 H480, H484, H490 GENBANK:XP_005378715
MER0576454 Chrysemys picta 907 180-394 E329 H328, H332, H338 GENBANK:XP_005303969
MER0575118 Chrysochloris asiatica 897 222-437 E372 H371, H375, H381 GENBANK:XP_006873130
MER0671323 Colius striatus 340 1-183 E123 H122, H126, H132 GENBANK:XP_010206379
MER0669048 Colobus angolensis 870 195-396 E345 H344, H348, H354 GENBANK:XP_011790125
MER0347792 Columba livia 683 73-189 E124 H123, H127, H133 UNIPROT:R7VQ27
MER0347792 Columba livia 683 73-189 E124 H123, H127, H133 UNIPROT:R7VQ27
MER0573265 Condylura cristata 982 307-522 E457 H456, H460, H466 GENBANK:XP_004688831
MER0572943 Corvus brachyrhynchos 747 28-234 E169 H168, H172, H178 GENBANK:XP_008635204
MER0668710 Corvus cornix 710 1-199 E134 H133, H137, H143 GENBANK:XP_010402349
MER0357648 Cricetulus griseus 905 234-396 E379 H378, H382, H388 GENBANK:XP_003495888
MER0357802 Cricetulus griseus 642 64-181 E116 H115, H119, H125 UNIPROT:G3GTX0
MER0357802 Cricetulus griseus 642 64-181 E116 H115, H119, H125 UNIPROT:G3GTX0
MER0663597 Cuculus canorus 711 1-191 E133 H132, H136, H142 GENBANK:XP_009566957
MER0567155 Cynoglossus semilaevis 951 221-433 E370 H369, H373, H379 GENBANK:XP_008306920
MER0091026 Danio rerio 884 212-425 E361 H360, H364, H370 GENBANK:CAM14445
MER0606214 Dasypus novemcinctus 787 82-286 E223 H222, H226, H232 GENBANK:XP_004484998
MER0664241 Egretta garzetta 744 56-257 E199 H198, H202, H208 GENBANK:XP_009640867
MER0565456 Elephantulus edwardii 892 217-432 E367 H366, H370, H376 GENBANK:XP_006901803
MER0563710 Eptesicus fuscus 882 207-408 E357 H356, H360, H366 GENBANK:XP_008141075
MER0098772 Equus caballus 748 100-288 E223 H222, H226, H232 GENBANK:XP_001502737
MER0660829 Esox lucius 946 219-428 E368 H367, H371, H377 GENBANK:XP_010891987
MER0661863 Esox lucius 946 217-431 E366 H365, H369, H375 GENBANK:XP_010865083
MER0560438 Falco cherrug 757 31-239 E179 H178, H182, H188 GENBANK:XP_005437706
MER0546168 Falco peregrinus 737 39-221 E161 H160, H164, H170 GENBANK:XP_005244762
MER0347001 Felis catus 864 194-356 E339 H338, H342, H348 GENBANK:XP_003992637
MER0569768 Ficedula albicollis 842 14-228 E163 H162, H166, H172 GENBANK:XP_005058894
MER0829307 Ficedula albicollis 729 26-184 E169 H168, H172, H178 GENBANK:-
MER0656499 Fukomys damarensis 708 42-234 E183 H182, H186, H192 GENBANK:XP_010638414
MER0655093 Fulmarus glacialis 629 26-208 E148 H147, H151, H157 GENBANK:XP_009582501
MER0557834 Galeopterus variegatus 710 34-242 E184 H183, H187, H193 GENBANK:XP_008569103
MER0176214 Gallus gallus 748 24-235 E170 H169, H173, H179 GENBANK:XP_001232457
MER0559714 Geospiza fortis 691 8-199 E134 H133, H137, H143 GENBANK:XP_005429388
MER0609431 Gorilla gorilla 810 199-400 E349 H348, H352, H358 GENBANK:XP_004052500
MER0652330 Haliaeetus leucocephalus 922 195-404 E344 H343, H347, H353 GENBANK:XP_010579782
MER0357804 Heterocephalus glaber 702 179-248 E231 H230, H234, H240 UNIPROT:G5B4B9
MER0357804 Heterocephalus glaber 702 179-248 E231 H230, H234, H240 UNIPROT:G5B4B9
MER0005545 Homo sapiens 889 214-429 E364 H363, H367, H373 GENBANK:EAW67784
MER0005545 Homo sapiens 889 214-429 E364 H363, H367, H373 GENBANK:EAW67784
MER0005545 Homo sapiens 889 214-429 E364 H363, H367, H373 GENBANK:EAW67784
MER0005545 Homo sapiens 889 214-429 E364 H363, H367, H373 GENBANK:EAW67784
MER0547369 Jaculus jaculus 945 270-471 E420 H419, H423, H429 GENBANK:XP_004665514
MER0650102 Larimichthys crocea 892 162-376 E311 H310, H314, H320 GENBANK:XP_010749835
MER0553856 Lepisosteus oculatus 946 220-434 E369 H368, H372, H378 UNIPROT:W5M9J1
MER0553856 Lepisosteus oculatus 946 220-434 E369 H368, H372, H378 UNIPROT:W5M9J1
MER0552502 Leptonychotes weddellii 852 190-405 E340 H339, H343, H349 GENBANK:XP_006731245
MER0548952 Lipotes vexillifer 892 217-418 E367 H366, H370, H376 GENBANK:XP_007456653
MER0259328 Loxodonta africana 784 114-324 E259 H258, H262, H268 GENBANK:XP_003417516
MER0357760 Macaca fascicularis 733 63-225 E208 H207, H211, H217 UNIPROT:G7PPV2
MER0357760 Macaca fascicularis 733 63-225 E208 H207, H211, H217 UNIPROT:G7PPV2
MER0167508 Macaca mulatta 958 283-498 E433 H432, H436, H442 GENBANK:XP_001112387
MER0357893 Macaca mulatta 564 1-56 E39 H38, H42, H48 UNIPROT:H9F7I6
MER0357893 Macaca mulatta 564 1-56 E39 H38, H42, H48 UNIPROT:H9F7I6
MER0468133 Macaca mulatta 89 1-89 missing missing, missing, missing UNIPROT:H9FJQ8
MER0468133 Macaca mulatta 89 1-89 missing missing, missing, missing UNIPROT:H9FJQ8
MER0646197 Manacus vitellinus 674 11-195 E135 H134, H138, H144 GENBANK:XP_008927655
MER0646317 Mandrillus leucophaeus 643 1-169 E118 H117, H121, H127 GENBANK:XP_011825423
MER0541592 Maylandia zebra 942 213-427 E362 H361, H365, H371 GENBANK:XP_004537999
MER0829191 Meleagris gallopavo 702 2-139 E124 H123, H127, H133 UNIPROT:G1MRA5
MER0541089 Melopsittacus undulatus 717 14-184 E137 H136, N140, N145 GENBANK:XP_005155309
MER0644428 Merops nubicus 570 13-194 E136 H135, H139, H145 GENBANK:XP_008937012
MER0643411 Mesitornis unicolor 700 1-181 E123 H122, H126, H132 GENBANK:XP_010180720
MER0544880 Mesocricetus auratus 905 229-430 E379 H378, H382, H388 GENBANK:XP_005084508
MER0539267 Microtus ochrogaster 906 230-431 E380 H379, H383, H389 GENBANK:XP_005347042
MER0166998 Monodelphis domestica 1077 404-618 E553 H552, H556, H562 GENBANK:XP_001373827
MER0012252 Mus musculus 905 229-444 E379 H378, H382, H388 GENBANK:AAI56803
MER0012252 Mus musculus 905 229-444 E379 H378, H382, H388 GENBANK:AAI56803
MER0012252 Mus musculus 905 229-444 E379 H378, H382, H388 GENBANK:AAI56803
MER0012252 Mus musculus 905 229-444 E379 H378, H382, H388 GENBANK:AAI56803
MER0357651 Mustela putorius 718 48-210 E193 H192, H196, H202 UNIPROT:M1EB62
MER0357651 Mustela putorius 718 48-210 E193 H192, H196, H202 UNIPROT:M1EB62
MER0562574 Myotis brandtii 717 42-243 E192 H191, H195, H201 GENBANK:XP_005863086
MER0613135 Myotis davidii 669 21-195 E144 H143, H147, H153 GENBANK:XP_006775151
MER0189689 Myotis lucifugus 926 251-452 E401 H400, H404, H410 GENBANK:XP_006098309
MER0829417 Myotis lucifugus 913 245-403 E388 H387, H391, H397 GENBANK:-
MER0641424 Nannospalax galili 908 232-433 E382 H381, H385, H391 GENBANK:XP_008850323
MER0534830 Neolamprologus brichardi 943 213-427 E362 H361, H365, H371 GENBANK:XP_006807277
MER0638928 Nestor notabilis 647 1-183 E123 H122, H126, H132 GENBANK:XP_010014465
MER0829114 Nestor notabilis 673 2-139 E124 H123, H127, H133 UNIPROT:A0A091S3R7
MER0829114 Nestor notabilis 673 2-139 E124 H123, H127, H133 UNIPROT:A0A091S3R7
MER0636510 Nipponia nippon 759 57-241 E181 H180, H184, H190 GENBANK:XP_009467866
MER0634858 Notothenia coriiceps 936 206-418 E355 H354, H358, H364 GENBANK:XP_010772863
MER0532435 Octodon degus 942 285-485 E434 H433, H437, H443 GENBANK:XP_004641515
MER0531117 Odobenus rosmarus 916 241-442 E391 H390, H394, H400 GENBANK:XP_004412090
MER0829448 Ophiophagus hannah 931 203-348 E346 H345, K349, M353 UNIPROT:V8NZD2
MER0829448 Ophiophagus hannah 931 203-348 E346 H345, K349, M353 UNIPROT:V8NZD2
MER0633736 Opisthocomus hoazin 757 13-195 E135 H134, H138, H144 GENBANK:XP_009931200
MER0530007 Orcinus orca 895 220-421 E370 H369, H373, H379 GENBANK:XP_004280541
MER0357758 Oreochromis niloticus 943 218-427 E362 H361, H365, H371 UNIPROT:I3KBU0
MER0357758 Oreochromis niloticus 943 218-427 E362 H361, H365, H371 UNIPROT:I3KBU0
MER0098040 Ornithorhynchus anatinus 694 38-232 E167 H166, H170, H176 GENBANK:XP_001507767
MER0828826 Ornithorhynchus anatinus 649 2-140 E125 H124, H128, H134 GENBANK:-
MER0528467 Orycteropus afer 896 221-436 E371 H370, H374, H380 GENBANK:XP_007953366
MER0256335 Otolemur garnettii 905 236-446 E381 H380, H384, H390 UNIPROT:H0WKG7
MER0256335 Otolemur garnettii 905 236-446 E381 H380, H384, H390 UNIPROT:H0WKG7
MER0346656 Ovis aries 899 231-441 E376 H375, H379, H385 GENBANK:XP_004019880
MER0357761 Pan paniscus 890 220-430 E365 H364, H368, H374 GENBANK:XP_003820149
MER0829133 Pan troglodytes 917 249-408 E392 H391, H395, H401 GENBANK:-
MER0518601 Panthera tigris 785 137-311 E260 H259, H263, H269 GENBANK:XP_007099486
MER0516319 Pantholops hodgsonii 841 168-383 E318 H317, H321, H327 GENBANK:XP_005981805
MER0526116 Papio anubis 888 213-414 E363 H362, H366, H372 GENBANK:XP_003911019
MER0524263 Pelodiscus sinensis 688 11-225 E160 H159, H163, H169 GENBANK:XP_006122386
MER0632483 Phaethon lepturus 309 30-210 E152 H151, H155, H161 GENBANK:XP_010280860
MER0603106 Phalacrocorax carbo 495 1-187 P130 S129, H132, H138 GENBANK:XP_009500387
MER0520752 Physeter catodon 900 225-426 E375 H374, H378, H384 GENBANK:XP_007119203
MER0628353 Picoides pubescens 835 108-315 E257 H256, H260, H266 GENBANK:XP_009904790
MER0523203 Poecilia formosa 945 216-430 E365 H364, H368, H374 GENBANK:XP_007579014
MER0513796 Poecilia reticulata 958 229-443 E378 H377, H381, H387 GENBANK:XP_008423472
MER0357766 Pongo abelii 888 218-380 E363 H362, H366, H372 UNIPROT:H2NFY5
MER0357766 Pongo abelii 888 218-380 E363 H362, H366, H372 UNIPROT:H2NFY5
MER0346981 Pteropus alecto 843 173-335 E318 H317, H321, H327 UNIPROT:L5L2H3
MER0346981 Pteropus alecto 843 173-335 E318 H317, H321, H327 UNIPROT:L5L2H3
MER0829249 Pygoscelis adeliae 560 2-139 E124 H123, H127, H133 UNIPROT:A0A093P1C3
MER0829249 Pygoscelis adeliae 560 2-139 E124 H123, H127, H133 UNIPROT:A0A093P1C3
MER0442976 Python bivittatus 707 1-188 E123 H122, H126, H132 GENBANK:XP_007435685
MER0027236 Rattus norvegicus 931 229-470 E379 H378, H408, H414 GENBANK:XP_235977
MER0556730 Rhinopithecus roxellana 1027 352-553 E502 H501, H505, H511 GENBANK:XP_010354857
MER0512818 Saimiri boliviensis 941 266-479 E416 H415, H419, H425 GENBANK:XP_003923906
MER0357665 Sarcophilus harrisii 783 115-324 E259 H258, H262, H268 UNIPROT:G3W9R1
MER0357665 Sarcophilus harrisii 783 115-324 E259 H258, H262, H268 UNIPROT:G3W9R1
MER0551089 Serinus canaria 703 1-190 E125 H124, H128, H134 GENBANK:XP_009096998
MER0597200 Sorex araneus 868 187-387 E337 H336, H340, H346 GENBANK:XP_004614215
MER0476662 Stegastes partitus 950 220-434 E369 H368, H372, H378 GENBANK:XP_008278780
MER0514364 Struthio camelus 610 125-241 missing missing, missing, missing GENBANK:XP_009678768
MER0357736 Sus scrofa 1019 349-559 E494 H493, H497, H503 GENBANK:XP_003130131
MER0357735 Taeniopygia guttata 825 104-313 E248 H247, H251, H257 GENBANK:XP_002193067
MER0265105 Takifugu rubripes 935 210-419 E354 H353, H357, H363 GENBANK:XP_003977068
MER0829336 Takifugu rubripes 812 165-321 E306 H305, H309, H315 UNIPROT:H2TXU1
MER0318466 Tauraco erythrolophus 741 47-227 E169 H168, H172, H178 GENBANK:XP_009990311
MER0829226 Tetraodon nigroviridis 836 112-270 E255 H254, H258, H264 GENBANK:-
MER0477777 Trichechus manatus 854 179-389 E329 H328, H332, H338 GENBANK:XP_004379439
MER0347622 Tupaia chinensis 654 83-200 E135 H134, H138, H144 UNIPROT:L9KP74
MER0347622 Tupaia chinensis 654 83-200 E135 H134, H138, H144 UNIPROT:L9KP74
MER0054057 Ursus maritimus 730 55-256 E205 H204, H208, H214 GENBANK:XP_008686625
MER0616674 Vicugna pacos 761 86-301 E236 H235, H239, H245 GENBANK:XP_006211730
MER0347367 Xenopus tropicalis 928 208-416 E352 H351, H355, H361 GENBANK:XP_002940685
MER0457460 Xiphophorus maculatus 592 233-440 E375 H374, H378, H384 GENBANK:XP_005816179
MER0448617 Zonotrichia albicollis 660 173-330 E322 H321, N325, missing GENBANK:XP_005492657
MER0448619 Zonotrichia albicollis 200 1-38 missing missing, missing, missing GENBANK:XP_005492658