Substrates for peptidase M10.039: metallopeptidase II (Bacteroides fragilis)

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
furin	P09958	27-107	peptide-Arg75+Ser-peptide	N	Val	Thr	Lys	Arg	Ser	Leu	Ser	Pro	Shiryaev et al., 2014
furin	P09958	27-107	peptide-Arg89+Glu-peptide	N	Arg	Leu	Gln	Arg	Glu	Pro	Gln	Val	Shiryaev et al., 2014
matrix metalloproteinase-14	P50281	21-111	peptide-Arg111+	N	Arg	Arg	Lys	Arg	Tyr	-	-	-	Shiryaev et al., 2014
protective antigen	P13423	30-764	peptide-Arg196+Ser-peptide	N	Arg	Lys	Lys	Arg	Ser	Thr	Ser	Ala	Shiryaev et al., 2014