Substrates for peptidase M10.015: membrane-type matrix metallopeptidase-2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
myelin basic protein isoform 1	P04370	1-246	peptide-Lys205+Ser-peptide	P	MS	Leu	Pro	Gln	Lys	Ser	Gln	His	Gly	Shiryaev et al., 2009	25495
myelin basic protein isoform 1	P04370	1-246	peptide-Asn75+Asn-peptide	P	MS	Asp	Pro	Lys	Asn	Asn	Trp	Gln	Gly	Shiryaev et al., 2009	25496
myelin basic protein isoform 1	P04370	1-246	peptide-Glu116+Leu-peptide	P	MS	Glu	Ser	Asp	Glu	Leu	Gln	Thr	Ile	Shiryaev et al., 2009	25497
myelin basic protein isoform 1	P04370	1-246	peptide-Ala150+Ser-peptide	P	MS	Leu	Ala	Thr	Ala	Ser	Thr	Met	Asp	Shiryaev et al., 2009	25498
myelin basic protein isoform 1	P04370	1-246	peptide-Ser172+Ile-peptide	P	MS	Ile	Leu	Asp	Ser	Ile	Gly	Arg	Phe	Shiryaev et al., 2009	25499
myelin basic protein isoform 1	P04370	1-246	peptide-Pro203+Gln-peptide	P	MS	Gly	Ser	Leu	Pro	Gln	Lys	Ser	Gln	Shiryaev et al., 2009	25500
myelin basic protein isoform 2	P04370-2	1-190	peptide-Tyr146+Leu-peptide	P	MS	Arg	Ser	Lys	Tyr	Leu	Ala	Thr	Ala	Shiryaev et al., 2009	25447
myelin basic protein isoform 2	P04370-2	1-190	peptide-Ser136+Gln-peptide	P	MS	Val	Met	Ala	Ser	Gln	Lys	Arg	Pro	Shiryaev et al., 2009	25448
myelin basic protein isoform 2	P04370-2	1-190	peptide-Ala135+Ser-peptide	P	MS	Asp	Val	Met	Ala	Ser	Gln	Lys	Arg	Shiryaev et al., 2009	25449
myelin basic protein isoform 2	P04370-2	1-190	peptide-Asp132+Val-peptide	P	MS	Gly	Gly	Leu	Asp	Val	Met	Ala	Ser	Shiryaev et al., 2009	25450
myelin basic protein isoform 2	P04370-2	1-190	peptide-Thr119+Ile-peptide	P	MS	Glu	Leu	Gln	Thr	Ile	Gln	Glu	Asp	Shiryaev et al., 2009	25451
myelin basic protein isoform 2	P04370-2	1-190	peptide-Glu116+Leu-peptide	P	MS	Glu	Ser	Asp	Glu	Leu	Gln	Thr	Ile	Shiryaev et al., 2009	25452
myelin basic protein isoform 2	P04370-2	1-190	peptide-His81+Pro-peptide	P	MS	Gln	Gly	Ala	His	Pro	Ala	Asp	Pro	Shiryaev et al., 2009	25453
myelin basic protein isoform 2	P04370-2	1-190	peptide-Lys34+Leu-peptide	P	MS	Ser	Val	Gly	Lys	Leu	Ser	Gln	Thr	Shiryaev et al., 2009	25454