$VAR1 = undef;

Summary for peptidase M10.015: membrane-type matrix metallopeptidase-2

Names
MEROPS Name	membrane-type matrix metallopeptidase-2
Other names	matrix metalloproteinase 15, membrane-type matrix metalloproteinase 2, MMP-15, matrix metalloproteinase, membrane-type 2, MT2-MMP, SMCP-2, MTMMP-2

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(M) >> Family M10 >> Subfamily A >> M10.015
Holotype	membrane-type matrix metallopeptidase-2 (Homo sapiens), Uniprot accession P51511 (peptidase unit: 128-319), MERNUM MER0002383
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00166
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (14 cleavages)
Activity status	human: active (Yana & Seiki, 2004) mouse: active (by similarity to human) (Tanaka et al., 1997)
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/MMP15
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/s/-/-ls/q/-/- (based on 14 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	2	2	1	0	0	1	0	2
Pro	0	2	0	1	1	0	0	2
Ala	0	1	2	2	0	2	1	1
Val	1	2	0	0	1	0	0	0
Leu	2	2	2	0	4	0	0	0
Ile	1	0	0	0	2	0	0	2
Met	0	1	1	0	0	1	1	0
Phe	0	0	0	0	0	0	0	1
Tyr	0	0	0	1	0	0	0	0
Trp	0	0	0	0	0	1	0	0
Ser	1	4	0	2	3	1	1	1
Thr	0	0	1	1	0	1	3	1
Cys	0	0	0	0	0	0	0	0
Asn	0	0	0	1	1	0	0	0
Gln	1	0	2	0	2	5	2	1
Asp	2	0	3	1	0	0	1	2
Glu	3	0	0	2	0	0	1	0
Lys	0	0	2	2	0	2	1	0
Arg	1	0	0	0	0	0	2	1
His	0	0	0	1	0	0	1	0