Substrates for peptidase C48.004: SENP6 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
ac-Gln-Thr-Gly-Gly-amino-trifluoromethylcoumarin			ac-Gln-Thr-Gly-Gly+amino-trifluoromethylcoumarin	S	Gln	Thr	Gly	Gly	AFC	-	-	-	Drag et al., 2008
ac-Leu-Arg-Gly-Gly-amino-trifluoromethylcoumarin			ac-Leu-Arg-Gly-Gly+amino-trifluoromethylcoumarin	S	Leu	Arg	Gly	Gly	AFC	-	-	-	Drag et al., 2008
PolySUMO2/SUMO3	P61956		peptide-Gly93+Lys11-peptide	N	Gln	Thr	Gly	Gly	Lys	Thr	Glu	Asn	Mendes et al., 2015
sumo1 dimer	P63165	2-97	peptide-Gly97+Lys-peptide	S	Gln	Thr	Gly	Gly	Lys	Xaa	Xaa	Xaa	Hattersley et al., 2011
sumo1-sumo2 dimer	P63165/P61956	2-97	peptide-Gly97+Lys-peptide	S	Gln	Thr	Gly	Gly	Lys	Xaa	Xaa	Xaa	Hattersley et al., 2011
sumo2 dimer	P61956	1-93	peptide-Gly93+Lys-peptide	S	Gln	Thr	Gly	Gly	Lys	Xaa	Xaa	Xaa	Hattersley et al., 2011
sumo2-sumo1 dimer	P61956/P63165	1-93	peptide-Gly93+Lys-peptide	S	Gln	Thr	Gly	Gly	Lys	Xaa	Xaa	Xaa	Hattersley et al., 2011
sumoylated protein PML	P61956/P29590	1-93	peptide-Gly93+Lys65-peptide	P	Gln	Thr	Gly	Gly	Lys	Cys	Pro	Lys	Hattersley et al., 2011
sumoylated protein PML	P61956/P29590	1-93	peptide-Gly93+Lys160-peptide	P	Gln	Thr	Gly	Gly	Lys	His	Glu	Ala	Hattersley et al., 2011
sumoylated protein PML	P61956/P29590	1-93	peptide-Gly93+Lys490-peptide	P	Gln	Thr	Gly	Gly	Lys	Met	Glu	Ser	Hattersley et al., 2011
sumoylated protein PML	P61956/P29590	1-93	peptide-Gly93+Lys497-peptide	P	Gln	Thr	Gly	Gly	Lys	Glu	Ala	Arg	Hattersley et al., 2011
sumoylated replication protein A 70 kDa DNA-binding subunit	P61956/P27694	1-93	peptide-Gly93+Lys449-peptide	P	Gln	Thr	Gly	Gly	Lys	Ser	Glu	Asn	Dou et al., 2010
sumoylated replication protein A 70 kDa DNA-binding subunit	P61956/P27694	1-93	peptide-Gly93+Lys577-peptide	P	Gln	Thr	Gly	Gly	Lys	Val	Glu	Thr	Dou et al., 2010