Literature for peptidase C48.004: SENP6 peptidase

(Topics flags: S Structure, T Target, P Specificity, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2026
1. Gu,A., Wang,B., Zhang,Y., Sun,C., Wei,Y., Yan,J., Yang,Y., Wang,Y., Liu,R., Zhang,R., Liu,J., Gu,C. and Wang,Y.
   SENP6 Restrains NLRP3 Inflammasome Activation via DeSUMOylation-Driven K48-Linked Ubiquitination of NLRP3 in Acute Lung Injury
   Research (Wash D C) (2026) 9, 1069-1069. PubMed  Europe PubMed DOI  PMC  EPMC
2. Yang,L., Xia,Y., Cui,Z., Lai,Y., Huang,Y., Xiong,Y., Chen,J. and Liu,T.
   Anisomycin Induces Senescence and Death of Ovarian Cancer Stem Cells Through the MicroRNA-340/SENP6/SUMOylation Pathway
   J Gene Med (2026) 28, e70081-e70081. PubMed  Europe PubMed DOI
2024
3. Guo,J., Zheng,H. and Xiong,S.
   SENP6 restricts the IFN-I-induced signaling pathway and antiviral activity by deSUMOylating USP8
   Cell Mol Immunol (2024) 21, 892-904. PubMed  Europe PubMed DOI
2023
4. Claessens,L.A., Verlaan-de Vries,M., de Graaf,I.J. and Vertegaal,A.C.O.
   SENP6 regulates localization and nuclear condensation of DNA damage response proteins by group deSUMOylation
   Nat Commun (2023) 14, 5893-5893. PubMed  Europe PubMed DOI  PMC  EPMC
5. Guo,F., Song,Y., Wu,L., Zhao,Y., Ma,X., Wang,J., Shao,M., Ji,H., Huang,F., Fan,X., Wang,S., Qin,G. and Yang,B.
   SUMO specific peptidase 6 regulates the crosstalk between podocytes and glomerular endothelial cells in diabetic kidney disease
   Biochim Biophys Acta Mol Basis Dis (2023) 1869, 166685-166685. PubMed  Europe PubMed DOI  K
6. Li,F., Wang,Y., Hwang,I., Jang,J.Y., Xu,L., Deng,Z., Yu,E.Y., Cai,Y., Wu,C., Han,Z., Huang,Y.H., Huang,X., Zhang,L., Yao,J., Lue,N.F., Lieberman,P.M., Ying,H., Paik,J. and Zheng,H.
   Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance
   Nat Commun (2023) 14, 1756-1756. PubMed  Europe PubMed DOI  PMC  EPMC
7. Liczmanska,M., Tatham,M.H., Mojsa,B., Eugui-Anta,A., Rojas-Fernandez,A., Ibrahim,A.F.M. and Hay,R.T.
   SUMO protease SENP6 protects the nucleus from hyperSUMOylation-induced laminopathy-like alterations
   Cell Rep (2023) 42, 112960-112960. PubMed  Europe PubMed DOI
8. van den Berg,S.J.W. and Jansen,L.E.T.
   SUMO control of centromere homeostasis
   Front Cell Dev Biol (2023) 11, 1193192-1193192. PubMed  Europe PubMed DOI  PMC  EPMC  V
2022
9. Bragado,L., Magalnik,M., Mammi,P., Romero,A., Gaioli,N., Pozzi,B. and Srebrow,A.
   SUMO conjugation regulates the activity of the Integrator complex
   Nucleic Acids Res (2022) 50, 12444-12461. PubMed  Europe PubMed DOI  PMC  EPMC
10. Schick,M., Zhang,L., Maurer,S., Maurer,H.C., Isaakaidis,K., Schneider,L., Patra,U., Schunck,K., Rohleder,E., Hofstetter,J., Baluapuri,A., Scherger,A.K., Slotta-Huspenina,J., Hettler,F., Weber,J., Engleitner,T., Maresch,R., Slawska,J., Lewis,R., Istvanffy,R., Habringer,S., Steiger,K., Baiker,A., Oostendorp,R.A.J., Miething,C., Lenhof,H.P., Bassermann,F., Chapuy,B., Wirth,M., Wolf,E., Rad,R., Muller,S. and Keller,U.
    Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma
    Nat Commun (2022) 13, 281-281. PubMed  Europe PubMed DOI  PMC  EPMC
2021
11. Xia,Q., Mao,M., Zeng,Z., Luo,Z., Zhao,Y., Shi,J. and Li,X.
    Inhibition of SENP6 restrains cerebral ischemia-reperfusion injury by regulating Annexin-A1 nuclear translocation-associated neuronal apoptosis
    Theranostics (2021) 11, 7450-7470. PubMed  Europe PubMed DOI  PMC  EPMC
2020
12. Colnaghi,L., Conz,A., Russo,L., Musi,C.A., Fioriti,L., Borsello,T. and Salmona,M.
    Neuronal Localization of SENP Proteins with Super Resolution Microscopy
    Brain Sci (2020) 10 PubMed  Europe PubMed DOI
2019
13. Wagner,K., Kunz,K., Piller,T., Tascher,G., Holper,S., Stehmeier,P., Keiten-Schmitz,J., Schick,M., Keller,U. and Muller,S.
    The SUMO isopeptidase SENP6 functions as a rheostat of chromatin residency in genome maintenance and chromosome dynamics
    Cell Rep (2019) 29, 480-494. PubMed  Europe PubMed DOI
2015
14. Long,Y., Liu,X., Wang,N., Zhou,H. and Zheng,J.
    Chloroquine attenuates LPS-mediated macrophage activation through miR-669n-regulated SENP6 protein translation
    Am J Transl Res (2015) 7, 2335-2345. PubMed  Europe PubMed  PMC  EPMC
15. Song,J.G., Xie,H.H., Li,N., Wu,K., Qiu,J.G., Shen,D.M. and Huang,C.J.
    SUMO-specific protease 6 promotes gastric cancer cell growth via deSUMOylation of FoxM1
    Tumour Biol (2015) 36, 9865-9871. PubMed  Europe PubMed DOI
2014
16. Alegre,K.O. and Reverter,D.
    Structural insights into the SENP6 loop1 structure in complex with SUMO2
    Protein Sci (2014) 23, 433-441. PubMed  Europe PubMed DOI  S
2013
17. Qian,J., Luo,Y., Gu,X. and Wang,X.
    Inhibition of SENP6-induced radiosensitization of human hepatocellular carcinoma cells by blocking radiation-induced NF-kappaB activation
    Cancer Biother Radiopharm (2013) 28, 196-200. PubMed  Europe PubMed DOI  T
2012
18. Reverter,D.
    SENP6 and SENP7 peptidases
    [ISSN:978-0-12-407743-0] (2012) 3, 2375-2379. DOI
2011
19. Albrow,V.E., Ponder,E.L., Fasci,D., Bekes,M., Deu,E., Salvesen,G.S. and Bogyo,M.
    Development of small molecule inhibitors and probes of human SUMO deconjugating proteases
    Chem Biol (2011) 18, 722-732. PubMed  Europe PubMed DOI  I
20. Alegre,K.O. and Reverter,D.
    Swapping small ubiquitin-like modifier (SUMO) isoform specificity of SUMO proteases SENP6 and SENP7
    J Biol Chem (2011) 286, 36142-36151. PubMed  Europe PubMed DOI
21. Hattersley,N., Shen,L., Jaffray,E.G. and Hay,R.T.
    The SUMO protease SENP6 is a direct regulator of PML nuclear bodies
    Mol Biol Cell (2011) 22, 78-90. PubMed  Europe PubMed DOI
2010
22. Mukhopadhyay,D., Arnaoutov,A. and Dasso,M.
    The SUMO protease SENP6 is essential for inner kinetochore assembly
    J Cell Biol (2010) 188, 681-692. PubMed  Europe PubMed DOI  PMC  EPMC
2009
23. Wang,Y., Mukhopadhyay,D., Mathew,S., Hasebe,T., Heimeier,R.A., Azuma,Y., Kolli,N., Shi,Y.B., Wilkinson,K.D. and Dasso,M.
    Identification and developmental expression of Xenopus laevis SUMO proteases
    PLoS ONE (2009) 4, e8462-e8462. PubMed  Europe PubMed DOI
2008
24. Drag,M., Mikolajczyk,J., Krishnakumar,I.M., Huang,Z. and Salvesen,G.S.
    Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family
    Biochem J (2008) 409, 461-469. PubMed  Europe PubMed DOI  P
2007
25. Mikolajczyk,J., Drag,M., Bekes,M., Cao,J.T., Ronai,Z. and Salvesen,G.S.
    Small Ubiquitin-related Modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs
    J Biol Chem (2007) 282, 26217-26224. PubMed  Europe PubMed DOI  P
2006
26. [YEAR:15-8-2006]Choi,S.J., Chung,S.S., Rho,E.J., Lee,H.W., Lee,M.H., Choi,H.S., Seol,J.H., Baek,S.H., Bang,O.S. and Chung,C.H.
    Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1
    J Biol Chem (15-8-2006) 281, 30669-30677. PubMed  Europe PubMed DOI
27. [YEAR:25-9-2006]Mukhopadhyay,D., Ayaydin,F., Kolli,N., Tan,S.H., Anan,T., Kametaka,A., Azuma,Y., Wilkinson,K.D. and Dasso,M.
    SUSP1 antagonizes formation of highly SUMO2/3-conjugated species
    J Cell Biol (25-9-2006) 174, 939-949. PubMed  Europe PubMed DOI  P
2000
28. [YEAR:12-5-2000]Kim,K.I., Baek,S.H., Jeon,Y.J., Nishimori,S., Suzuki,T., Uchida,S., Shimbara,N., Saitoh,H., Tanaka,K. and Chung,C.H.
    A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs
    J Biol Chem (12-5-2000) 275, 14102-14106. PubMed  Europe PubMed DOI
29. Yeh,E.T., Gong,L. and Kamitani,T.
    Ubiquitin-like proteins: new wines in new bottles
    Gene (2000) 248, 1-14. PubMed  Europe PubMed DOI