Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Substrates for peptidase C30.001: coronavirus picornain 3C-like peptidase-1

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
avian infectious bronchitis coronavirus papain-like peptidase 1 P0C6Y1 1-6629 peptide-Gln2779+Ser-peptide N Ser Arg Leu Gln Ser Gly Phe Lys Ziebuhr et al., 2000 16301
avian infectious bronchitis coronavirus papain-like peptidase 1 P0C6Y1 1-6629 peptide-Gln3086+Ser-peptide N Val Arg Leu Gln Ser Ser Phe Val Ziebuhr et al., 2000 16303
avian infectious bronchitis coronavirus papain-like peptidase 1 P0C6Y1 1-6629 peptide-Gln3379+Ala-peptide N Ala Thr Val Gln Ala Lys Leu Ser Ziebuhr et al., 2000 16306
avian infectious bronchitis coronavirus papain-like peptidase 1 P0C6Y1 1-6629 peptide-Gln3462+Ser-peptide N Thr Val Leu Gln Ser Val Thr Gln Ziebuhr et al., 2000 16307
avian infectious bronchitis coronavirus papain-like peptidase 1 P0C6Y1 1-6629 peptide-Gln3672+Asn-peptide N Val Val Leu Gln Asn Asn Glu Leu Ziebuhr et al., 2000 16318
avian infectious bronchitis coronavirus papain-like peptidase 1 P0C6Y1 1-6629 peptide-Gln3783+Ser-peptide N Val Val Leu Gln Ser Lys Gly His Ziebuhr et al., 2000 16312
avian infectious bronchitis coronavirus papain-like peptidase 1 P0C6Y1 1-6629 peptide-Gln3928+Ser-peptide N Ser Ser Val Gln Ser Val Ala Gly Ziebuhr et al., 2000 16314
avian infectious bronchitis coronavirus papain-like peptidase 1 P0C6Y1 1-6629 peptide-Gln4868+Ser-peptide P Thr Thr Leu Gln Ser Cys Gly Val Ziebuhr et al., 2000 16321
avian infectious bronchitis coronavirus papain-like peptidase 1 P0C6Y1 1-6629 peptide-Gln5468+Gly-peptide N Thr Ser Leu Gln Gly Thr Gly Leu Ziebuhr et al., 2000 16324
avian infectious bronchitis coronavirus papain-like peptidase 1 P0C6Y1 1-6629 peptide-Gln5989+Ser-peptide N Ser Ala Leu Gln Ser Ile Asp Asn Ziebuhr et al., 2000 16326
avian infectious bronchitis coronavirus papain-like peptidase 1 P0C6Y1 1-6629 peptide-Gln6327+Ser-peptide N Pro Gln Leu Gln Ser Ala Trp Thr Ziebuhr et al., 2000 16328
human coronavirus 229E papain-like peptidase 1 Q05002 1-6758 peptide-Gln2965+Ala-peptide N Ser Thr Leu Gln Ala Gly Leu Arg Ziebuhr et al., 2000 16302
human coronavirus 229E papain-like peptidase 1 Q05002 1-6758 peptide-Gln3267+Ser-peptide N Val Asn Leu Gln Ser Gly Lys Thr Ziebuhr et al., 2000 16304
human coronavirus 229E papain-like peptidase 1 Q05002 1-6758 peptide-Gln3546+Ser-peptide N Ser Thr Val Gln Ser Lys Leu Thr Ziebuhr et al., 2000 16308
human coronavirus 229E papain-like peptidase 1 Q05002 1-6758 peptide-Gln3629+Ser-peptide N Ser Ile Leu Gln Ser Val Ala Ser Ziebuhr et al., 2000 16309
human coronavirus 229E papain-like peptidase 1 Q05002 1-6758 peptide-Gln3824+Asn-peptide N Val Lys Leu Gln Asn Asn Glu Ile Ziebuhr et al., 2000 16313
human coronavirus 229E papain-like peptidase 1 Q05002 1-6758 peptide-Gln3933+Ala-peptide N Val Arg Leu Gln Ala Gly Lys Gln Ziebuhr et al., 2000 16315
human coronavirus 229E papain-like peptidase 1 Q05002 1-6758 peptide-Gln4068+Ser-peptide N Thr Ala Ile Gln Ser Phe Asp Asn Ziebuhr et al., 2000 16317
human coronavirus 229E papain-like peptidase 1 Q05002 1-6758 peptide-Gln4995+Ala-peptide N Thr Val Leu Gln Ala Ala Gly Leu Ziebuhr et al., 2000 16322
human coronavirus 229E papain-like peptidase 1 Q05002 1-6758 peptide-Gln5592+Ser-peptide N Thr Asp Leu Gln Ser Glu Ser Ser Ziebuhr et al., 2000 16325
human coronavirus 229E papain-like peptidase 1 Q05002 1-6758 peptide-Gln6110+Gly-peptide P Val Asn Leu Gln Gly Leu Glu Asn Ziebuhr et al., 2000 16327
human coronavirus 229E papain-like peptidase 1 Q05002 1-6758 peptide-Gln6458+Ser-peptide N Pro Gln Leu Gln Ser Ala Glu Trp Ziebuhr et al., 2000 16329
replicase polyprotein 1ab P0C6X9 1-7176 peptide-Gln3333+Ser-peptide N Ser Phe Leu Gln Ser Gly Ile Val Ziebuhr et al., 2000 16305
replicase polyprotein 1ab P0C6X9 1-7176 peptide-Gln3635+Ser-peptide N Val Lys Leu Gln Ser Lys Arg Thr Ziebuhr et al., 2000 16310
replicase polyprotein 1ab P0C6X9 1-7176 peptide-Gln4013+Ser-peptide N Gln Ala Leu Gln Ser Glu Phe Val Ziebuhr et al., 2000 16316
replicase polyprotein 1ab P0C6X9 1-7176 peptide-Gln4207+Asn-peptide N Val Val Leu Gln Asn Asn Glu Leu Ziebuhr et al., 2000
replicase polyprotein 1ab P0C6X9 1-7176 peptide-Gln4317+Ala-peptide N Val Arg Leu Gln Ala Gly Thr Ala Ziebuhr et al., 2000 16319
replicase polyprotein 1ab P0C6X9 1-7176 peptide-Gln4454+Ser-peptide N Ser Gln Phe Gln Ser Lys Asp Thr Ziebuhr et al., 2000 16320
replicase polyprotein 1ab P0C6X9 1-7176 peptide-Gln5382+Ser-peptide N Ala Val Leu Gln Ser Val Gly Ala Ziebuhr et al., 2000 16323
replicase polyprotein 1ab P0C6X9 1-7176 peptide-Gln6877+Ala-peptide P Pro Arg Leu Gln Ala Ala Ala Asp Ziebuhr et al., 2000
replicase polyprotein 1ab P0C6X9 1-7176 peptide-Gln6503+Ser-peptide P Thr Arg Leu Gln Ser Leu Glu Asn Ziebuhr et al., 2000
replicase polyprotein 1ab P0C6X9 1-7176 peptide-Gln5982+Cys-peptide P Pro Arg Leu Gln Cys Thr Thr Asn Ziebuhr et al., 2000
replicase polyprotein 1ab P0C6X9 1-7176 peptide-Gln3921+Ser-peptide P Ser Gln Ile Gln Ser Arg Leu Thr Ziebuhr et al., 2000
replicase polyprotein 1ab P0C6X9 1-7176 peptide-Gln4013+Ser-peptide P NT Gln Ala Leu Gln Ser Glu Phe Val Lu et al., 1998
replicase polyprotein 1ab P0C6X9 1-7176 peptide-Gln4207+Asn-peptide P NT Val Val Leu Gln Asn Asn Glu Leu Lu et al., 1998 16311
replicase polyprotein 1ab P0C6X9 1-7176 peptide-Gln3333+Ser-peptide P MU Ser Phe Leu Gln Ser Gly Ile Val Pinon et al., 1999
replicase polyprotein 1ab P0C6X9 1-7176 peptide-Gln3635+Ser-peptide P MU Val Lys Leu Gln Ser Lys Arg Thr
replicase polyprotein 1ab P0C6X9 1-7176 peptide-Gln5382+Ser-peptide P MU Ala Val Leu Gln Ser Val Gly Ala Pinon et al., 1999
replicase polyprotein 1ab P0C6X9 1-7176 peptide-Gln3921+Ser-peptide N MU Ser Gln Ile Gln Ser Arg Leu Thr Bost %etla, 2000
replicase polyprotein 1ab P0C6X9 1-7176 peptide-Gln4317+Ala-peptide N MU Val Arg Leu Gln Ala Gly Thr Ala Bost %etla, 2000
replicase polyprotein 1ab P0C6X9 1-7176 peptide-Gln4454+Ser-peptide N MU Ser Gln Phe Gln Ser Lys Asp Thr Bost %etla, 2000
replicase polyprotein 1ab P0C6X9 1-7176 peptide-Gln5982+Cys-peptide N Pro Arg Leu Gln Cys Thr Thr Asn
replicase polyprotein 1ab P0C6X9 1-7176 peptide-Gln6503+Ser-peptide N Thr Arg Leu Gln Ser Leu Glu Asn
replicase polyprotein 1ab P0C6X9 1-7176 peptide-Gln6877+Ala-peptide N Pro Arg Leu Gln Ala Ala Ala Asp

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use