Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase C30.001: coronavirus picornain 3C-like peptidase-1

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Lee,Y.Y., Lee,A.R., Seo,S., Park,U., Kim,T., Lee,S.K., Jeong,H., Jeong,S.J., Kweon,Y.C., Eun Park,G., Kim,M.J., Kim,B.G., Kwon,T., Cho,N.H., Moo Kwon,H., Myung,K., Lee,S.M. and Park,C.Y.<br>Human coronavirus 3CL protease manipulates host protein STIM1 to facilitate immune evasion<br>Proc Natl Acad Sci U S A (2025) 122, e2503436122-e2503436122. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Perry,J.K., Itskanov,S., Bilello,J.P. and Lansdon,E.B.<br>A structural roadmap for the formation of the coronavirus nsp3/nsp4 double membrane vesicle pore and its implications for polyprotein processing and replication/transcription<br>J Virol (2025) , e0145725-e0145725. PubMed  Europe PubMed DOI
    3. 2014
  3. Deng,X., StJohn,S.E., Osswald,H.L., O'Brien,A., Banach,B.S., Sleeman,K., Ghosh,A.K., Mesecar,A.D. and Baker,S.C.<br>Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistance<br>J Virol (2014) 88, 11886-11898. PubMed  Europe PubMed DOI  I
    4. 2013
  4. Stobart,C.C., Sexton,N.R., Munjal,H., Lu,X., Molland,K.L., Tomar,S., Mesecar,A.D. and Denison,M.R.<br>Chimeric exchange of coronavirus nsp5 proteases (3CLpro) identifies common and divergent regulatory determinants of protease activity<br>J Virol (2013) 87, 12611-12618. PubMed  Europe PubMed DOI
    5. 2012
  5. Lim,H.-S., Jang,C.-Y., Nam,J., Li,M., Hong,J.-S., Bae,H., Ju,H.-J., Kim,H.G., Ford,R.E. and Domier,L.L.<br>Characterization of the in vitro activities of the P1 and helper component proteases of Soybean mosaic virus strain G2 and Tobacco vein mottling virus<br>Plant Pathol J (2012) 28, 197-201. DOI
  6. Stobart,C.C., Lee,A.S., Lu,X. and Denison,M.R.<br>Temperature-sensitive mutants and revertants in the coronavirus nonstructural protein 5 protease (3CLpro) define residues involved in long-distance communication and regulation of protease activity<br>J Virol (2012) 86, 4801-4810. PubMed  Europe PubMed DOI
  7. Stobart,C.C. and Denison,M.R.<br>Coronavirus picornain-like cysteine proteinase<br>[ISSN:978-0-12-407743-0] (2012) 3, 2436-2441. DOI
    8. 2008
  8. Sparks,J.S., Donaldson,E.F., Lu,X., Baric,R.S. and Denison,M.R.<br>A novel mutation in murine hepatitis virus nsp5, the viral 3C-like proteinase, causes temperature-sensitive defects in viral growth and protein processing<br>J Virol (2008) 82, 5999-6008. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Zhao,Q., Li,S., Xue,F., Zou,Y., Chen,C., Bartlam,M. and Rao,Z.<br>Structure of the main protease from a global infectious human coronavirus, HCoV-HKU1<br>J Virol (2008) 82, 8647-8655. PubMed  Europe PubMed DOI  PMC  EPMC  S
    10. 2007
  10. Deming,D.J., Graham,R.L., Denison,M.R. and Baric,R.S.<br>Processing of open reading frame 1a replicase proteins nsp7 to nsp10 in murine hepatitis virus strain a59 replication<br>J Virol (2007) 81, 10280-10291. PubMed  Europe PubMed DOI  PMC  EPMC
    11. 2004
  11. Denison,M.R.<br>Coronavirus picornain-like cysteine proteinase<br>[ISSN:0-12-079610-4] (2004) 2, 1382-1385.  V
    12. 1999
  12. [YEAR:25-10-1999]Pinon,J.D., Teng,H. and Weiss,S.R.<br>Further requirements for cleavage by the murine coronavirus 3C-like proteinase: identification of a cleavage site within ORF1b<br>Virology (25-10-1999) 263, 471-484. PubMed  Europe PubMed DOI
  13. Ziebuhr,J. and Siddell,S.G.<br>Processing of the human coronavirus 229E replicase polyproteins by the virus-encoded 3C-like proteinase: Identification of proteolytic products and cleavage sites common to pp1a and pp1ab<br>J Virol (1999) 73, 177-185. PubMed  Europe PubMed  PMC  EPMC
    14. 1998
  14. Denison,M.R., Sims,A.C., Gibson,C.A. and Lu,X.T.<br>Processing of the MHV-A59 gene 1 polyprotein by the 3C-like proteinase<br>Adv Exp Med Biol (1998) 440, 121-127. PubMed  Europe PubMed
  15. Lu,X.T., Sims,A.C. and Denison,M.R.<br>Mouse hepatitis virus 3C-like protease cleaves a 22-kilodalton protein from the open reading frame 1a polyprotein in virus-infected cells and in vitro<br>J Virol (1998) 72, 2265-2271. PubMed  Europe PubMed  PMC  EPMC
  16. Sims,A.C., Lu,X.T. and Denison,M.R.<br>Expression, purification, and activity of recombinant MHV-A59 3CLpro<br>Adv Exp Med Biol (1998) 440, 129-134. PubMed  Europe PubMed
    17. 1997
  17. Lu,Y. and Denison,M.R.<br>Determinants of mouse hepatitis virus 3C-like proteinase activity<br>Virology (1997) 230, 335-342. PubMed  Europe PubMed DOI
  18. Pinon,J.D., Mayreddy,R.R., Turner,J.D., Khan,F.S., Bonilla,P.J. and Weiss,S.R.<br>Efficient autoproteolytic processing of the MHV-A59 3C-like proteinase from the flanking hydrophobic domains requires membranes<br>Virology (1997) 230, 309-322. PubMed  Europe PubMed DOI
  19. Seybert,A., Ziebuhr,J. and Siddell,S.G.<br>Expression and characterization of a recombinant murine coronavirus 3C-like proteinase<br>J Gen Virol (1997) 78, 71-75. PubMed  Europe PubMed
    20. 1996
  20. Gao,H.Q., Schiller,J.J. and Baker,S.C.<br>Identification of the polymerase polyprotein products p72 and p65 of the murine coronavirus MHV-JHM<br>Virus Res (1996) 45, 101-109. PubMed  Europe PubMed
  21. Lu,X., Lu,Y. and Denison,M.R.<br>Intracellular and in vitro-translated 27-kDa proteins contain the 3C-like proteinase activity of the coronavirus MHV-A59<br>Virology (1996) 222, 375-382. PubMed  Europe PubMed DOI  I
    22. 1995
  22. Kim,J.C., Spence,R.A., Currier,P.F., Lu,X. and Denison,M.R.<br>Coronavirus protein processing and RNA synthesis is inhibited by the cysteine proteinase inhibitor E64d<br>Virology (1995) 208, 1-8. PubMed  Europe PubMed DOI  I
  23. Liu,D.X. and Brown,T.D.<br>Characterisation and mutational analysis of an ORF 1a-encoding proteinase domain responsible for proteolytic processing of the infectious bronchitis virus 1a/1b polyprotein<br>Virology (1995) 209, 420-427. PubMed  Europe PubMed DOI
  24. Lu,Y., Lu,X. and Denison,M.R.<br>Identification and characterization of a serine-like proteinase of the murine coronavirus MHV-A59<br>J Virol (1995) 69, 3554-3559. PubMed  Europe PubMed  PMC  EPMC
    25. 1994
  25. Bonilla,P.J., Gorbalenya,A.E. and Weiss,S.R.<br>Mouse hepatitis virus strain A59 RNA polymerase gene ORF 1a: heterogeneity among MHV strains<br>Virology (1994) 198, 736-740. PubMed  Europe PubMed DOI
    26. 1991
  26. Lee,H.J., Shieh,C.K., Gorbalenya,A.E., Koonin,E.V., La Monica,N., Tuler,J., Bagdzhadzhyan,A. and Lai,M.M.<br>The complete sequence (22 kilobases) of murine coronavirus gene 1 encoding the putative proteases and RNA polymerase<br>Virology (1991) 180, 567-582. PubMed  Europe PubMed DOI

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use